Eric C. Lai: Publications


Selected Recent Publications

Shang R, Baek SC, Kim K, Kim B, Kim VN, Lai EC. Genomic Clustering Facilitates Nuclear Processing of Suboptimal Pri-miRNA Loci. Molecular Cell and Developmental Cell. 2020 Apr 16;78(2):303-316.e4. doi: 10.1016/j.molcel.2020.02.009.

Daniel L Garaulet, Binglong Zhang, Lu Wei, Elena Li, Eric C Lai. miRNAs and Neural Alternative Polyadenylation Specify the Virgin Behavioral State. Developmental Cell. 2020 Jun 22;S1534-5807(20)30454-8. doi: 10.1016/j.devcel.2020.06.004. 

Lin C.-J., F. Hu, R. Dubruille, J. Vedanayagam, J. Wen, P. Smibert, B. Loppin and E. C. Lai (2018). The hpRNA/RNAi pathway is essential to resolve intragenomic conflict to permit transmission of sons. Developmental Cell 46: 316-326. (Featured in Developmental Cell 46: 251-253).

Joseph, B., S. Kondo and E. C. Lai (2018). Short cryptic exons mediate recursive splicing in Drosophila (2018). Nature Structural and Molecular Biology 25: 365-371.

Jee, D., J.-S. Yang, S. M. Park, D.’J. Farmer, J. Wen, T. Chou, A. Chow, M. T. McManus, M. G. Kharas and E. C. Lai (2018). Dual strategies for Argonaute2 Slicer-dependent miRNA biogenesis regulate erythropoiesis. Molecular Cell 69: 265-278.

Kavaler, J., H. Duan, R. Aradhya, L. F. de Navas, B. Joseph, B. Shklyar and E. C. Lai (2018). miRNA suppression of a Notch repressor directs non-neuronal fate in Drosophila mechanosensory organs. Journal of Cell Biology 217: 571–583. Featured in JCB Special Collection on Stem Cells and Development (July 2018).

Duan, H., L. F. de Navas, F. Hu, K. Sun, Y. E. Mavromatakis, K. Viets, C. Zhou, J. Kavaler, R. Johnston, Jr., A. Tomlinson, and E. C. Lai (2018). The mir-279/996 cluster represses receptor tyrosine kinase signaling to determine cell fates in the Drosophila eye. Development, dev159053 doi: 10.1242/dev.159053.

Mohammed, J., A. S. Flynt, A. M. Panzarino, M. Mondal, M. DeCruz, A. Siepel and E. C. Lai (2018). Deep experimental profiling of microRNA diversity, deployment, and evolution across the Drosophila genus. Genome Research 28: 52-65.

Kondo S., J. Vedanayagam, J. Mohammed, S. Eizadshenass, L. Kan, N. Pang, R. Aradhya, A. Siepel, J. Steinhauer and E. C. Lai (2017). New genes often acquire male-specific functions but rarely become essential in Drosophila. Genes and Development 31: 1841–1846. (Highlighted in Genes and Dev 31: 1825-1826.)

Sanfilippo P., J. Wen and E. C. Lai (2017). Landscape and evolution of tissue-specific alternative polyadenylation across Drosophila species. Genome Biology 18: 229. doi: 10.1186/s13059-017-1358-0.

Kan, L., A. V. Grozhik, J. Vedanayagam, D. P. Patil, N. Pang, K.-S. Lim, Y.-C. Huang, B. Joseph, C.-J. Lin, V. Despic, J. Guo, D. Yan, S. Kondo, W.-M. Deng, P. C. Dedon, S. R. Jaffrey and E. C. Lai (2017). The m6A pathway facilitates sex determination in Drosophila. Nature Communications 8:15737, 1-1 (doi: 10.1038/ncomms15737).

Lin, C.-J., J. Wen, F. Bejarano, F. Hu, D. Bortolamiol-Becet, L. Kan, P. Sanfilippo, S. Kondo and E. C. Lai (2017). Characterization of a TUTase/RNase complex required for Drosophila gametogenesis. RNA 23: 284-296.

Garaulet, D., K. Sun, W. Li, J. Wen, A. M. Panzarino, J. L. O’Neil, P. R. Hiesinger, Michael W. Young, and E. C. Lai (2016). miR-124 regulates diverse aspects of rhythmic behavior in Drosophila. Journal of Neuroscience 36: 3414-2.