Molecular Biology Program

The John Maciejowski Lab

Research

John Maciejowski, PhD
John Maciejowski, PhD

The nuclear envelope is a regulated membrane barrier that separates the nucleus from the cytosol in eukaryotes. Although the NE is often depicted as a static barrier, new research has identified conditions where nuclear envelope rupturing causes a loss of compartmentalization. Nuclear envelope ruptures are rapidly repaired in the nucleus, but persist at aberrant, nuclear compartments, such as micronuclei and DNA bridges, that form around mis-segregated chromosomes. Compromised nuclear compartmentalization can result in DNA damage, inflammation, and clustered mutagenesis. The Maciejowski lab seeks to understand how the nuclear envelope safeguards the genome and prevents immune recognition of chromosomal DNA. We approach these problems using a combination of cell biology, biochemistry, and genomics. More information about our research can be found at http://maciejowskilab.com/.

Research Projects

The John Maciejowski Lab

Publications

People

John Maciejowski, PhD

John Maciejowski, PhD

  • Molecular biologist John Maciejowski studies the causes of complex chromosome rearrangements and the patterns of hypermutation that shape cancer genomes.
  • PhD, Louis V. Gerstner, Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center
maciejoj@mskcc.org
Email Address

Members

Yanyang Chen
Yanyang Chen

Graduate Research Assistant

Kevan Chu
Kevan Chu

Research Technician

Allie Dananberg
Allie Dananberg

Graduate Research Assistant

Adonis C. John
Adonis C. John

Administrative Assistant

John Maciejowski
John Maciejowski

Principal Investigator

Lisa Mohr, PhD
Lisa Mohr

Research Fellow

Eleonore Toufektchan
Eleonore Toufektchan

Research Fellow

Patrick von Morgen
Patrick von Morgen

Research Scholar

Lab Affilations

Achievements

  • NIH Pathway to Independence Award (2016)
  • Tri-Institutional Breakout Prize for Junior Investigators (2016)
  • Regeneron Prize for Creative Innovation (2016)
  • Pew Biomedical Scholar

Open Positions

Open Positions

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Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

John Maciejowski discloses the following relationships and financial interests:

No disclosures meeting criteria for time period


The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.


This page and data include information for a specific MSK annual disclosure period (January 1, 2019 through disclosure submission in spring 2020). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.


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