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Yosif Martin Ganat, PhD

Postdoctoral Fellow - currently: Research Investigator, Arvinas,, New Haven, CT

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Yosif Martin Ganat

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The focus of my work is to use transgenic human embryonic stem cells (hESCs) that express GFP under promoters that are specific to midbrain dopamine (mDA) neurons in order to purify, characterize, and graft these cells in a mouse model of Parkinson’s disease. I am also working with the Rutishauser lab to overexpress polysialic acid neural cell adhesion molecule (PSA-NCAM) in grafted hESC-derived mDA neurons to increase their integration into the host CNS. Additionally, I am a co-host and producer of THE Stem Cell Podcast - the official podcast of the International Society for Stem Cell Research. Together with Dr. Christopher Fasano we interview stem cell scientists and discuss recent advances in the field.

Publications

Optogenetics enables functional analysis of human embryonic stem cell-derived grafts in a Parkinson’s disease model. Steinbeck JA, Choi SJ, Mrejeru A, Ganat Y, Deisseroth K, Sulzer D, Mosharov EV, Studer L. Nat Biotechnol. 2015 Feb;33(2):204-9. doi: 10.1038/nbt.3124. Epub 2015 Jan 12.

A cell engineering strategy to enhance the safety of stem cell therapies. Oricchio E, Papapetrou EP, Lafaille F, Ganat YM, Kriks S, Ortega-Molina A, Mark WH, Teruya-Feldstein J, Huse JT, Reuter V, Sadelain M, Studer L, Wendel HG. Cell Rep. 2014 Sep 25;8(6):1677-85. doi: 10.1016/j.celrep.2014.08.039. Epub 2014 Sep 18.

Human iPSC-based modeling of late-onset disease via progerin-induced aging. Miller JD, Ganat YM, Kishinevsky S, Bowman RL, Liu B, Tu EY, Mandal PK, Vera E, Shim JW, Kriks S, Taldone T, Fusaki N, Tomishima MJ, Krainc D, Milner TA, Rossi DJ, Studer L. Cell Stem Cell. 2013 Dec 5;13(6):691-705. doi: 10.1016/j.stem.2013.11.006.

Enhancement of polysialic Acid expression improves function of embryonic stem-derived dopamine neuron grafts in parkinsonian mice. Battista D, Ganat Y, El Maarouf A, Studer L, Rutishauser U. Stem Cells Transl Med. 2014 Jan;3(1):108-13. doi: 10.5966/sctm.2013-0084. Epub 2013 Dec 5.

Specification of functional cranial placode derivatives from human pluripotent stem cells.Dincer Z, Piao J, Niu L, Ganat Y, Kriks S, Zimmer B, Shi SH, Tabar V, Studer L. Cell Rep. 2013 Dec 12;5(5):1387-402. doi: 10.1016/j.celrep.2013.10.048. Epub 2013 Nov 27.

Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells.Maroof AM, Keros S, Tyson JA, Ying SW, Ganat YM, Merkle FT, Liu B, Goulburn A, Stanley EG, Elefanty AG, Widmer HR, Eggan K, Goldstein PA, Anderson SA, Studer L.>Cell Stem Cell. 2013 May 2;12(5):559-72. doi: 10.1016/j.stem.2013.04.008.

Identification of embryonic stem cell–derived midbrain dopaminergic neurons for engraftment. Ganat YM, Kriks S, Calder E, Tu Y, Jia F, Harrison N, Tomishima MJ, Rutishauser U and Studer L. Journal of Clinical Investigation, 2012 Jul 2. pii: 58767.

Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease. Kriks S, Shim JW, Piao J, Ganat YM, Wakeman DR, Xie Z, Carrillo-Reid L, Auyeung G, Antonacci C, Buch A, Yang L, Beal MF, Surmeier DJ, Kordower JH, Tabar V, Studer L. Nature. 2011 Nov 6;480(7378):547-51. doi: 10.1038/nature10648.

miR-371-3 expression predicts neural differentiation propensity in human pluripotent stem cells. Kim H, Lee G, Ganat Y, Papapetrou EP, Lipchina I, Socci ND, Sadelain M, Studer L. Cell Stem Cell. 2011 Jun 3;8(6):695-706.

Astroglial cells in the external granular layer are precursors of cerebellar granule neurons in neonates. Silbereis J, Heintz T, Taylor MM, Ganat Y, Ment LR, Bordey A, Vaccarino F. Mol Cell Neurosci. 2010 Aug;44(4):362-73. Epub 2010 May 12

Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Lee G, Papapetrou EP, Kim H, Chambers SM, Tomishima MJ, Fasano CA, Ganat YM, Menon J, Shimizu F, Viale A, Tabar V, Sadelain M, Studer L. Nature. 2009 Sep 17;461(7262):402-6. Epub 2009 Aug 19.

Precursors with glial fibrillary acidic protein promoter activity transiently generate GABA interneurons in the postnatal cerebellum. Silbereis J, Cheng E, Ganat YM, Ment LR, Vaccarino FM. Stem Cells. 2009 May;27(5):1152-63.

Fgfr1 is required for cortical regeneration and repair after perinatal hypoxia. Fagel DM, Ganat Y, Cheng E, Silbereis J, Ohkubo Y, Ment LR, Vaccarino FM. J Neurosci. 2009 Jan 28;29(4):1202-11.

Astroglial cells in development, regeneration, and repair. Vaccarino FM, Fagel DM, Ganat Y, Maragnoli ME, Ment LR, Ohkubo Y, Schwartz ML, Silbereis J, Smith KM. Neuroscientist. 2007 Apr;13(2):173-85. Review.

Early postnatal astroglial cells generate multilineage precursors and neural stem cells in vivo. Ganat YM, Silbereis J, Cave C, Ngu H, Anderson JM, Ohkubo Y, Ment LR, Vaccarino FM. J Neurosci. 2006 Aug 16;26(33):8609-21.

Cortical neurogenesis enhanced by chronic perinatal hypoxia. Fagel DM, Ganat Y, Silbereis J, Ebbitt T, Stewart W, Zhang H, Ment LR, Vaccarino FM. Exp Neurol. 2006 May;199(1):77-91.

Chronic hypoxia up-regulates fibroblast growth factor ligands in the perinatal brain and induces fibroblast growth factor-responsive radial glial cells in the sub-ependymal zone. Ganat Y. Soni S. Chacon M. Schwartz ML. Vaccarino FM. Neuroscience. 112(4):977-91, 2002.

Stem cells in neurodevelopment and plasticity. Vaccarino FM. Ganat Y. Zhang Y. Zheng W. Neuropsychopharmacology. 25(6):805-15, 2001 Dec.