Developmental Biology Program

The Lorenz Studer Lab

Lorenz Studer, MD

Director, Center for Stem Cell Biology

Our laboratory aims at exploiting recent advances in stem cell biology to develop radically new therapies for degenerative disease and cancer. The main focus in the lab is on the biology and application of human embryonic stem (ES) and human induced pluripotent (iPS) cells. Pluripotent stem cells can provide a truly unlimited source for deriving therapeutically relevant cell types for applications in human disease modeling or regenerative medicine.

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Research Projects

Featured News

Why Are Only Some Cells ‘Competent’ to Form Cancer? MSK Scientists Say Context Is Key

Friday, September 3, 2021

Experiments with zebrafish and human pluripotent stem cells reveal the necessary ingredients, besides genetic mutations, that fuel the development of melanoma.

Q&A

Taking Aim at Parkinson’s Disease: A Conversation with Developmental Biologist Lorenz Studer

Friday, October 9, 2020

In an interview in September 2020, Dr. Studer spoke about what he hopes he and his fellow investigators can accomplish with this generous support.

Announcement

MSK’s Lorenz Studer Named a 2015 MacArthur Fellow

Tuesday, September 29, 2015

The awards are given annually to people in an array of fields in the arts and sciences.

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Publications

Giacomelli E, Vahsen BF, Calder EL, Xu Y, Scaber J, Gray E, Dafinca R, Talbot K, Studer L. Human stem cell models of neurodegeneration: From basic science of amyotrophic lateral sclerosis to clinical translation. Cell Stem Cell. 2022 Jan 6;29(1):11-35. doi: 10.1016/j.stem.2021.12.008.PMID: 34995492

Baggiolini A, Callahan SJ, Montal E, Weiss JM, Trieu T, Tagore MM, Tischfield SE, Walsh RM, Suresh S, Fan Y, Campbell NR, Perlee SC, Saurat N, Hunter MV, Simon-Vermot T, Huang TH, Ma Y, Hollmann T, Tickoo SK, Taylor BS, Khurana E, Koche RP, Studer L, White RM. Developmental chromatin programs determine oncogenic competence in melanoma. Science. 2021 Sep 3;373(6559):eabc1048. doi: 10.1126/science.abc1048. Epub 2021 Sep 3.PMID: 34516843

Kim TW, Piao J, Koo SY, Kriks S, Chung SY, Betel D, Socci ND, Choi SJ, Zabierowski S, Dubose BN, Hill EJ, Mosharov EV, Irion S, Tomishima MJ, Tabar V, Studer L. Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use. Cell Stem Cell. 2021 Feb 4;28(2):343-355.e5. doi: 10.1016/j.stem.2021.01.005.PMID: 33545081

Piao J, Zabierowski S, Dubose BN, Hill EJ, Navare M, Claros N, Rosen S, Ramnarine K, Horn C, Fredrickson C, Wong K, Safford B, Kriks S, El Maarouf A, Rutishauser U, Henchcliffe C, Wang Y, Riviere I, Mann S, Bermudez V, Irion S, Studer L, Tomishima M, Tabar V. Preclinical Efficacy and Safety of a Human Embryonic Stem Cell-Derived Midbrain Dopamine Progenitor Product, MSK-DA01. Cell Stem Cell. 2021 Feb 4;28(2):217-229.e7. doi: 10.1016/j.stem.2021.01.004.PMID: 33545080

Guttikonda SR, Sikkema L, Tchieu J, Saurat N, Walsh RM, Harschnitz O, Ciceri G, Sneeboer M, Mazutis L, Setty M, Zumbo P, Betel D, de Witte LD, Pe’er D, Studer L. Fully defined human pluripotent stem cell-derived microglia and tri-culture system model C3 production in Alzheimer’s disease. Nat Neurosci. 2021 Feb 8. doi: 10.1038/s41593-020-00796-z. Online ahead of print.PMID: 33558694

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People

Lorenz Studer, MD

Director, Center for Stem Cell Biology

The Studer laboratory investigates human stem cells as tools to understand normal and pathological development in the nervous system and to develop cell-based strategies for regenerative medicine.
MD, Universitat Bern

[email protected]: Email Address
212-639-6126: Office Phone

Members

Elizabeth L Calder, PhD
Senior Research Scientist

Gabriele Ciceri, Ph.D. — Gabriele Ciceri, PhD
Senior Research Scientist

James Hackland, PhD
Senior Research Scientist

Johannes Jungverdorben, PhD
Research Associate

Silvia K. Benito Kwiecinski — Silvia Benito Kwiecinski, PhD
Research Fellow

Trisha Sikder

Lab Technician

Danaysy Frias
Senior Administrative Assistant

Lab Alumni

Oliver Härschnitz, MD, PhD
Research Associate - NYSTEM Training Award at the CSCB

Daniela Cornacchia, PhD
Postdoctoral Fellow

Jason Tchieu
Postdoctoral Fellow - currently: Assistant Professor, Cincinnati Children’s Hospital, Cincinnati, OH

Scott J. Callahan
Vice President, Director of Medical Strategy at Havas Health & You, New York, NY

Gustav Cederquist
Graduate Student – currently: Resident in Radiation Oncology, Memorial Sloan Kettering Cancer Center

Eveline Gutzwiller
Postdoctoral Fellow - currently: Neurology resident, Mount Sinai Medical School, New York, NY

Nadja Zeltner, PhD — Nadja Zeltner
Postdoctoral fellow – currently, Assistant Professor, University of Georgia

Faranak Fattahi, MS — Faranak Fattahi
Graduate Student - currently, Sandler Faculty Fellow, UCSF

Michelle Vincendeau
Postdoctoral Fellow – currently: Group leader, Helmholtz Zentrum, Munich, Germany

Bastian Zimmer, PhD — Bastian Zimmer
Postdoctoral Fellow - currently: Group leader, Evotec, Hamburg, Germany

Mohamed Soliman
Medical Student, Weill Cornell - currently: Physician/Psychiatrist, Ann Arbor, Michigan

Elsa Vera
Postdoctoral Fellow - currently: Senior Machine Learning Engineer - Digital Intelligence at JPMorgan Chase & Co.

Yuchen Qi
Postdoctoral Fellow - currently: Consultant, The Boston Consulting Group

Sarah Kishinevsky
Graduate Student – currently, Director of the Dean's Entrepreneurship Lab at Weill Cornell

Julius Steinbeck
Postdoctoral Fellow - currently: Freelance Neurologist and Stem Cell Expert, Germany

Yosif Martin Ganat
Postdoctoral Fellow - currently: Research Investigator, Arvinas,, New Haven, CT

Sonja Kriks
Postdoctoral Fellow - currently Senior Scientist at Neurona Therapeutics Inc

Jae-won Shim
Postdoctoral fellow - currently: Assistant Prof., Soonchunhayng University

Stuart Chambers
Postdoctoral Fellow - currently, Senior Scientist at Amgen

Justine D. Miller
Principal Scientist at AbbVie, Boston, MA

Fabien Lafaille
PhD student – currently: Senior Scientist, BlueRock Thearpeutics, New York, NY

Yvonne Gruber Mica
Manager, Field Applications - Cell Biology Thermo Fisher Scientific New York, NY

Inna Lipchina
Graduate Student - currently: Senior Scientist, Cellarity

Gabsang Lee
Postdoctoral Fellow - currently: Associate Prof., Johns Hopkins School of Medicine

Sun Young Chung
Lab Technician - currently: medical student, Harvard University

Asif Maroof
Graduate Student - currently: Assistant Professor, The University of Texas at San Antonio

Yechiel Elkabetz
Postdoctoral fellow - Currently: Principal Investigator, Max Planck Institute for Molecular Genetics,

Marietta Saldias Montivero

Lab Technician - currently: MD/PhD student

Sabrina Desbordes
Postdoctoral fellow - currently: Assistant Prof., Helmholtz Institute

Tiziano Barberi
Postdoctoral Fellow - Currently: Associate Scientist, Texas BioMed Research Institute, SW National Primate Research Center

Mark J Tomishima, PhD — Mark J Tomishima
Currently, Sr. Director, CNS Bioprocess at BlueRock Therapeutics

Viviane Tabar
Chair, Department of Neurosurgery; Theresa Feng Chair in Neurosurgical Oncology

Anselme Perrier
Postdoctoral Fellow - currently: Principal Investigator, iSTEM, INSERM, France

Hyesoo Kim
Currently, Assistant Professor at Johns Hopkins School of Medicine

Agnete Kirkeby
PhD student – currently, Associate Professor of Stem Cell Biology, University of Copenhagen, Denmark

Lab Affiliations

Achievements

ISSCR Achievement Award (2022)
Jacob & Louise Gabbay Award in Biotechnology & Medicine (2018)
Ogawa-Yamanaka Stem Cell Prize, Gladstone Institutes (2017)
MacArthur Fellow (2015)
Member, American Society of Clinical Investigation (2014)

Annemarie Opprecht Parkinson Award, Annemarie Opprecht Foundation (2012)
Louise and Allston Boyer Young Investigator in Basic Research, Memorial Sloan Kettering Cancer Center (2005)

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

Career Opportunities

Apply now

Get in Touch

[email protected]

Lab Head Email
212-639-6126

Office Phone
212-717-3642

Office Fax
212-639-8510

Lab Phone

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Lorenz Studer discloses the following relationships and financial interests:

BlueRock Therapeutics
Intellectual Property Rights; Provision of Services
DaCapo Brainscience, Inc.
Ownership / Equity Interests
Fujifilm Cellular Dynamics, Inc.
Intellectual Property Rights
Luxa Biotechnology, LLC
Provision of Services

Neurona Therapeutics
Ownership / Equity Interests; Provision of Services (uncompensated)
Roche
Provision of Services
Rumi Scientific, Inc.
Provision of Services (uncompensated)
Vita Therapeutics, Inc.
Ownership / Equity Interests; Provision of Services (uncompensated)

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2021 through disclosure submission in spring 2022). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].

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