The Michael Kharas Lab: Publications

Visit PubMed for a full listing of Michael G. Kharas’ journal articles

Pubmed is an online index of biomedical articles maintained by the U.S. National Library of Medicine and the National Institutes of Health.

Research Articles

Park S-M, Choo H, Thornton A, Barlowe TS, Chou T, Chhangawala S, Fairchild L, Taggart J, Chow A, Schurer A, Witkin M, Shevach EM, Krivtsov A, Armstrong SA, Leslie C, Kharas MG*. IKZF2 drives leukemia stem cell self-renewal and inhibits myeloid differentiation. Cell Stem Cell. 2018 Nov 13; 24: 1-13

Vu L, Pickering BF, Cheng Y, Zaccara S, Nguyen D, Minuesa G, Chou T, Chow A, Saletore Y, MacKay M, Schulman J, Famulare C, Patel M, Klimek VM, Garrett-Bakelman FE, Melnick A, Carroll M, Mason CE, Jaffrey S* & Kharas MG*. The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells. Nature Medicine.  2017 September 18.  doi:10.1038/nm.4416. 

Bhagat TD, Chen SI, Bartenstein M, Barlowe AT, Tivnan P, Amin E, Marcondesz M, Sanders MA, Hoogenboezem RM, Will B, Giricz O, Kambhampati S, Ramachandra N, Mantzaris I, Sukrithan V, Sohal D, Wickrema A, Yeung C, Gritsman K, Aplan P, Hochedlinger K, Yu Y, Pradhan K, Greally JM, Mukherjee S, Pellagatti A, Boultwood J, Steidl U, Raaijmakers MHGP, Deeg HJ, Kharas MG*, Verma A*. Epigenetically Aberrant Stroma In MDS Propagates Disease Via Wnt/-Catenin Activation. Cancer Research. 2017 July 6:  doi:  10.1158/0008-5472.

Vu L, Prieto C, Amin EM, Chhangawala S, Krivtsov A, Calvo-Vidal MN, Chou T, Chow A, Minuesa G, Park SM, Barlowe TS, Taggart J, Tivnan P, Deering RP, Chu LP, Kwon J-A, Mayden C, Perales-Paton J, Arshi A, Gönen M, Paietta E, Tallman MS, Glass J, Bakelman FG,  Melnick A, Levine R, Al-Shahrour F, Järås M, Hacohen N, Hwang A, Garippa R,. Lengner CJ, Armstrong SA, Cerchietti L, Cowley GS, Root D, Doench J, Leslie C, Ebert BL, Kharas MG*. Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells. Nature genetics. 2017 Apr 24:  doi:10.1038/ng.3854. 

Kotini AG, Chang CJ, Chow A, Yuan H, Ho TC, Wang T, Vora S, Husser C, Olszewska M, Alexander S, Perumal D, Teruya-Feldstein J, Klimek VM, Spyridonidis A, Rampal R, Silverman L, Reddy EP, Papaemmanuil, E, Parekh S, Greenbaum B, Leslie C, Kharas MG*, Papapetrou EP*. Stage-specific induced pluripotent stem cells delineate a roadmap to myeloid transformation. Cell Stem Cell. 2017 Mar 2; 20:1-14.

Taggart J, Ho TZ, Amin E, Xu H, Barlowe T, Perez AR, Tivnan P, Okabe R, Lengner C, Verma A, Roboz GJ, Guzman ML, Leslie CS, Nimer SD and Kharas MG*.  MSI2 Is Required for Maintaining the Activated Myelodysplastic Syndrome Stem Cell. Nat Comm. 2016 Feb 22; 7:10739, PMCID: PMC4764878. 

Park SM, Gonen M, Vu L, Minuesa G, Tivnan P, Barlowe TS, Taggart J, Lu Y, Deering RP, Hacohen N, Figueroa ME, Paietta E,Tallman MS, Melnick A, Levine R, Leslie C, Lengner C and Kharas MG*. Musashi2 sustains the MLL leukemia stem cell regulatory program. J Clin Invest, 2015 Mar 2;125(3):1286-98. PMCID: PMC4362230. 

Minuesa G, Antczak C, Shum D, Radu C, Bhinder B, Li Y, Djaballah H, Kharas MG*. A 1536-well Fluorescence Polarization Assay to Screen for Modulators of the MUSASHI Family of RNA-Binding Proteins. Comb Chem Hig Throughput Screen. 2014: 17(7):596-609. PMCID:PMC4135234. 

Park SM, Deering RP, Lu Y, Tivnan P, Lianoglou S, Al-Shahrour F, Ebert BL, Hacohen N, Leslie C, Daley GQ, Lengner CJ, Kharas MG*. Musashi-2 controls cell fate, lineage bias, and TGF- β signaling in HSCs. J Exp Med. 2014 Jan 13;211(1):71-87. PMCID: PMC3892968. 

Reviews

Vu L, Cheng Y, Kharas MG. The Biology of m6A RNA Methylation in Normal and Malignant Hematopoiesis.  Cancer Discovery. 2018 Dec 21:  doi. 10.1158/2159-8290.CD-18-0959. 

Kharas, MG*, Lengner, C*. Stem cells, cancer, and MUSASHI in blood and guts. Trends in Cancer. Invited review. 2017 Apr 9:  doi: 10.1016/j.trecan.2017.03.007.