Molecular Pharmacology Program
The Michael Kharas Lab
Erazo T, Evans CM, Zakheim D, Chu KL, Refermat AY, Asgari Z, Yang X, Da Silva Ferreira M, Mehta S, Russo MV, Knezevic A, Zhang XP, Chen Z, Fennell M, Garippa R, Seshan V, de Stanchina E, Barbash O, Batlevi CL, Leslie CS, Melnick AM, Younes A, Kharas MG. TP53 mutations and RNA-binding protein MUSASHI-2 drive resistance to PRMT5-targeted therapy in B-cell lymphoma. Nat Commun. 2022 Sep 27;13(1):5676. doi: 10.1038/s41467-022-33137-8.
Jeong S, Savino AM, Chirayil R, Cheng Y, Barin E, Park SM, Schurer A, Mullarky E, Cantley LC, Kharas MG*, Keshari KR*. Serine synthesis pathway flux is essential for acute myeloid leukemia cells to proliferate in fructose-rich conditions. Cell Metab. 5 January 2021, Pages 145-159.
Prieto C, Nguyen DTT, Liu Z,Wheat J, Perez A, Gourkanti S, Chou T, Barin E, Velleca A, Rohwetter T, Barin E, Chow A, Taggart J, Hoskova K, Dhodapkar M, Schurer A, Barlowe TS, Vu LP, Leslie C, Steidl U, Rabadan R, Kharas MG*. Transcriptional control of CBX5 by the RNA binding proteins RBMX/L1 maintain chromatin state in myeloid leukemia. Nat Cancer. July 2021. 5: 741-757.
Cheng Y*, Xie W*, Pickering BF, Chu KL, Savino AM, Yang X, Luo H, Nguyen DTT, Mo S, Barin E, Velleca A, Rohwetter T, Patel DJ, Jaffrey SR, Kharas MG*. N6-methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation Cancer Cell. July 2021.
Erazo T, Evans CM, Zakheim D, Chu KL, Refermat AY, Asgari Z, Yang Z, Ferreira MD, Mehta S, Russo MV, Knezevic A, Zhang XP, Chen Z, Fennell M, Garippa R, Seshan V, de Stanchina E, Barbash O, Batlevi CL, Melnick AM, Younes A*, Kharas MG*. TP53 mutations and RNA binding protein MUSASHI2 drive resistance to PRMT5-targeted therapy in B-cell lymphoma. Nat Comm 2022 September 27. 13(5626).
Michael G. Kharas, PhD
- Cancer biologist Michael Kharas studies RNA regulators of self-renewal in both normal and leukemic hematopoiesis.
- PhD, University of California Irvine
- [email protected]
- Email Address
- Leukemia and Lymphoma Society Career Development Award (2017)
- Alex Lemonade Stand Foundation ‘A’ Award (2016)
- American Society of Hematology Junior Faculty Scholar Award (2011)
- Kimmel Scholar Award (2013)
- V-Scholar Award (2013)
To learn more about available postdoctoral opportunities, please visit our Career Center
As a Research Technician you will perform research activities in collaboration with internal/external personnel to complete science-based projects. You will normally receive detailed instructions while making observations, analyzing data and interpreting results according to laboratory procedures. The Research Technician will provide support to all technical/research staff and postdocs.
Get in Touch
Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.
Michael G. Kharas discloses the following relationships and financial interests:
858 Therapeutics, Inc.
Ownership / Equity Interests; Provision of Services
Provision of Services
Provision of Services
The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.
This page and data include information for a specific MSK annual disclosure period (January 1, 2021 through disclosure submission in spring 2022). This data reflects interests that may or may not still exist. This data is updated annually.