To heal and regenerate, tissues must “know” that they are injured. How wound detection occurs is unclear. If it malfunctions, infection, allergic disease, sterile inflammation, and fibrosis, or cancer may result. What are the first cues that unleash rapid inflammatory and healing responses after injury? We study the elusive Signal 0 of wound detection. We hope that this ultimately will enable us to stop vicious auto-inflammatory circles at the doorstep, or to turn immune cells against tumors.
Philipp Niethammer, PhD
Research FocusCell biologist Philipp Niethammer investigates tissue damage responses with advanced imaging approaches in zebrafish.
EducationPhD, European Molecular Biology Laboratories & Hamburg University, Germany
- Huang C, Niethammer P. Tissue Damage Signaling Is a Prerequisite for Protective Neutrophil Recruitment to Microbial Infection in Zebrafish. Immunity. 2018 May 15;48(5):1006-1013.e6.
- Jelcic M, Enyedi B, Xavier JB, Niethammer P. Image-Based Measurement of H2O2 Reaction-Diffusion in Wounded Zebrafish Larvae. Biophys J. 2017 May 9;112(9):2011–2018. PMCID: PMC5425381