Structural Biology Program

The Stephen Long Lab

Research

Stephen B. Long, PhD
Stephen B. Long, PhD
Member

Our laboratory uses a combination of structural biology and biophysical techniques to discover how ion channels and membrane-embedded enzymes function at the atomic level. The proteins we study are crucial for the function of the immune system, vision, cell differentiation, and embryonic development, and they are potential targets for diseases including immune disorders and cancer. Our discoveries lead to new understandings of the fundamental mechanisms of these proteins and guide efforts to control them using small molecule and biologic modulators for potential use as therapeutic agents. 

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Publications

Hou, X.*, Outhwaite, I.R.*, Pedi, L., and Long, S.B. (2020). Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation. Elife 9. (Abstract | Open Conformation Cryo-EM map & Atomic Coordinates). *X. Hou and I.R. Outhwaite are co-first authors.

Wang, C., Jacewicz, A., Delgado, B.D., Baradaran, R., and Long, S.B. (2020). Structures reveal gatekeeping of the mitochondrial Ca(2+) uniporter by MICU1-MICU2. Elife 9. (Abstract | Holocomplex Cryo-EM map & Atomic Coordinates | MICU1-MICU2 complex Cryo-EM map & Atomic Coordinates)

Wang, C.*, Baradaran, R.*, and Long, S.B. (2020). Structure and Reconstitution of an MCU-EMRE Mitochondrial Ca2+ Uniporter Complex. J Mol Biol 432, 5632-5648. (Abstract | MCU-EMRE Cryo-EM map & Atomic Coordinates). *C. Wang and R. Baradaran are co-first authors.

Miller, A. N.*, Vaisey, G.*, & Long, S. B. (2019). Molecular mechanisms of gating in the calcium-activated chloride channel bestrophin. eLife (Abstract | open state Cryo-EM map & Atomic Coordinates).  *A. N. Miller and G. Vaisey are co-first authors.

Vaisey, G., & Long, S. B. (2018). An allosteric mechanism of inactivation in the calcium-dependent chloride channel BEST1. The Journal of General Physiology, jgp.201812190. (Abstract)

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People

Stephen B. Long, PhD

Stephen B. Long, PhD

Member

  • The Long laboratory discovers the atomic mechanisms of ion channels and enzymatic membrane proteins with an eye to using these discoveries to benefit humanity.
  • BA, Physics, Amherst College, 1994
  • PhD, Biochemistry, Duke University, 2001
  • Postdoc, Rockefeller University, 2007
longs@mskcc.org
Email Address
212-639-2903
Office Phone

Members

Rozbeh Baradaran
Rozbeh Baradaran

Postdoc

Thomas Benz

Research Technician

Bryce D. Delgado

Graduate Student

Xiaowei Hou, PhD
Xiaowei Hou

Senior Research Scientist

Agata Jacewicz
Agata Jacewicz

Senior Research Scientist

Yiyang Jiang
Yiyang Jiang

Research Scholar

Ian Outhwaite
Ian Outhwaite

Research Technician

George Vaisey, MBiochem
George Vaisey

Graduate Student

Pictured: David J. Van Dongen
David J. Van Dongen

Graduate Student

Chongyuan Wang
Chongyuan Wang

Postdoctoral Fellow

Lab Alumni
Veronica Kane-Dickson

Postdoctoral Fellow

Pictured: David Kerr
David Kerr

Undergraduate Researcher

Shana Burstein

Research Technician

Melinda Diver

Graduate Student

Pictured: Alexandria Miller
Alexandria N. Miller

Postdoctoral Fellow

Leanne Pedi
Leanne Pedi

Senior Research Assistant

Lab Affiliations

Achievements

  • Louise and Allston Boyer Young Investigator in Basic Research, Memorial Sloan Kettering Cancer Center (2016)
  • Louise and Allston Boyer Young Investigator in Basic Research, Memorial Sloan Kettering Cancer Center (2016)
  • Burroughs Wellcome Career Award in the Biomedical Sciences (2006-2014)
  • Burroughs Wellcome Career Award in the Biomedical Sciences (2006-2014)

Open Positions

Postdoctoral Fellow Positions

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Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Stephen B. Long discloses the following relationships and financial interests:

No disclosures meeting criteria for time period


The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.


This page and data include information for a specific MSK annual disclosure period (January 1, 2020 through disclosure submission in spring 2021). This data reflects interests that may or may not still exist. This data is updated annually.

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