Pictured: Stephen Long laboratory

Our laboratory uses a combination of cryo-electron microscopy, x-ray crystallography, and functional approaches to study the mechanisms of eukaryotic ion channels involved in calcium signaling and membrane-embedded enzymes.

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Stephen B. Long, PhD

Stephen B. Long, PhD



Research Focus

The Long laboratory studies ion channels and enzymatic membrane proteins.


  • BA, Physics, Amherst College, 1994
  • PhD, Biochemistry, Duke University, 2001
  • Postdoc, Rockefeller University, 2007

Lab Members

  • Miller, A. N.*, Vaisey, G.*, & Long, S. B. (2019). Molecular mechanisms of gating in the calcium-activated chloride channel bestrophin. eLife (Abstract | open state Cryo-EM map | Atomic Coordinates).  *A. N. Miller and G. Vaisey are co-first authors.
  • Vaisey, G., & Long, S. B. (2018). An allosteric mechanism of inactivation in the calcium-dependent chloride channel BEST1. The Journal of General Physiology, jgp.201812190. (Abstract)
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Selected Achievements
  • Louise and Allston Boyer Young Investigator in Basic Research, Memorial Sloan Kettering Cancer Center (2016)
  • Burroughs Wellcome Career Award in the Biomedical Sciences (2006-2014)