My laboratory investigates mechanisms of normal to tumor cell conversion, with a focus on basic epithelial cell biology, including the process entosis that we recently described. Entosis induces cell death by driving the formation of cell-in-cell structures and may be a novel mechanism of tumor suppression.
Michael Overholtzer, PhD
Research FocusCell biologist Michael Overholtzer studies the mechanisms of tumor initiation and progression, cell adhesion, and cell death.
- PhD, Princeton University
- Florey O, Overholtzer M. Autophagy proteins in macroendocytic engulfment. Trends Cell Biol. 2012 Jul;22(7):374-80. doi: 10.1016/j.tcb.2012.04.005. Epub 2012 May 19.
- Krajcovic M, Overholtzer M. Mechanisms of ploidy increase in human cancers: a new role for cell cannibalism. Cancer Res. 2012 Apr 1;72(7):1596-601. doi: 10.1158/0008-5472.CAN-11-3127. Epub 2012 Mar 23.