Chromatin Accessibility Assays

• ATAC-seq: Genome-wide chromatin accessibility profiling
• FFPE-ATAC: Optimized ATAC-seq for formalin-fixed paraffin-embedded (FFPE) samples

Chromatin Immunoprecipitation (ChIP) & Related Assays

• ChIP-seq: Histone modification and transcription factor profiling
• Low-input ChIP: Optimized for as few as 50,000 cells
• FFPE-ChIP: Histone modification profiling from FFPE samples
• CUT&RUN and CUT&Tag: High-sensitivity alternatives to ChIP-seq
• Cell-free DNA ChIP: Chromatin profiling from circulating cell-free DNA (cfDNA)

3D Genomics & Chromatin Conformation Assays

• Hi-C: Genome-wide chromatin architecture mapping
• Micro-C: High-resolution 3D chromatin organization profiling
• HiChIP: Chromatin conformation capture for protein-bound interactions
• 4C-seq: Targeted analysis of chromatin looping and interactions

DNA Modifications Profiling

• EM-seq: Enzymatic methyl-seq for high-resolution 5mC detection
• 5hmC-seq: Profiling of 5-hydroxymethylcytosine (5hmC) modifications

Computational Epigenomics & Bioinformatics

• Data processing and quality control for ATAC-seq, ChIP-seq, CUT&RUN, 3D genomics, and DNA modification assays
• Peak calling, motif enrichment, and differential analysis
• Custom bioinformatics support for novel epigenomic applications
• Integration of multi-omics datasets for deeper biological insights

Technology Development & Innovation

• Optimization of existing protocols for challenging sample types, such as FFPE and low-input samples
• Development of novel epigenomic profiling methods for emerging research needs
• Collaborative projects to refine and expand cutting-edge epigenetic assays

Additional Support & Collaborations

• Automated Library Preparation: ChIP and CUT&RUN libraries are prepared on an automated platform at IGO, improving consistency and quality
• Experimental Design & Consultation: We provide expert guidance on protocol selection, sample preparation, and data interpretation
• Whether you need state-of-the-art experimental assays, bioinformatics expertise, or cutting-edge epigenomics innovation, ERIL is here to support and drive your research forward.