Cancer Biology & Genetics Program

The Andrea Ventura Lab

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Research

Pictured: Andrea Ventura
Andrea Ventura, MD, PhD

One of the most exciting discoveries of the last two decades has been the identification of a large number of non-coding RNAs and the realization that they play essential roles in mammalian development and in diseases. Their study and the characterization of their contribution to the pathogenesis of human cancer is the central focus of our group. To learn more about our lab, please visit our blog and webpage at: www.venturalaboratory.com.

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Research Projects

The Andrea Ventura Lab

Featured News

Andrea Ventura
At Work: Cancer Biologist Andrea Ventura

Andrea Ventura’s research is focused on microRNA expression, as he seeks to understand how small RNAs act on genes to promote or suppress cancer.
In the Lab
Cancer biologist Andrea Ventura
Disorderly DNA: Researchers Simulate a Common Cause of Lung Cancer

MSK scientists have created a mouse model that replicates a subtype of non-small cell lung cancer caused by a chromosomal rearrangement.
Video
Pictured: Scott Lowe & Zhen Zhao
A Look Inside the Geoffrey Beene Cancer Research Center

Watch our scientists discuss how the Geoffrey Beene Center helped Memorial Sloan Kettering establish a progressive approach to modern cancer research.

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Publications

Li X., Pritykin Y., Concepcion C.P., Lu Y., La Rocca G., Zhang M., King B., Cook P.J., Au Y. W., Popow O., Paulo J.A., Otis G.A., Mastroleo C., Ogrodowski P., Schreiner R., Haigis K.M., Betel D., Leslie C.S., Ventura A. High-Resolution In Vivo Identification of miRNA Targets by Halo-Enhanced Ago2 Pull-Down Molecular Cell, June 3, 2020 https://doi.org/10.1016/j.molcel.2020.05.009 PMID:32497493

Perez AR, Pritykin Y, Vidigal JA, Chhangawala S, Zamparo L, Leslie CS, Ventura A. GuideScan software for improved single and paired CRISPR guide RNA design. Nat Biotechnol. 2017 Mar 6. doi: 10.1038/nbt.3804. [Epub ahead of print] PMID: 28263296

Han YC, Vidigal JA, Mu P, Yao E, Singh I, González AJ, Concepcion CP, Bonetti C, Ogrodowski P, Carver B, Selleri L, Betel D, Leslie C, Ventura A. An allelic series of miR-17～92-mutant mice uncovers functional specialization and cooperation among members of a microRNA polycistron. Nat Genet. 2015 Jun 1. doi: 10.1038/ng.3321. [Epub ahead of print] PubMed PMID: 26029871.

Danilo Maddalo, Eusebio Manchado, Carla P. Concepcion, Ciro Bonetti, Joana A. Vidigal, Yoon-Chi Han, Paul Ogrodowski, Alessandra Crippa, Natasha Rekhtman, Elisa de Stanchina, Scott W. Lowe, and Andrea Ventura. In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system. Nature. 2014 Oct 22.

Concepcion CP, Han YC, Mu P, Bonetti C, Yao E, D’Andrea A, Vidigal JA, Maughan WP, Ogrodowski P, Ventura A. Intact p53-Dependent Responses in miR-34-Deficient Mice. PLoS Genet. 2012 Jul; 8 (7) :e1002797.

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People

Pictured: Andrea Ventura

Andrea Ventura, MD, PhD

  • Cancer biologist Andrea Ventura studies non-coding RNAs in cancer and development
  • MD, Catholic University of Rome (Italy)
  • PhD, European Institute of Oncology (Milan Italy), Open University (London, UK)
  • Postdoctoral, Center for Cancer Research, Massachusetts Institute of Technology (Cambridge, MA)
[email protected]
Email Address
646-888-3068
Office Phone
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Members

Paul Ogrodowski
Paul Ogrodowski

Research Assistant

Raymond Wu
Raymond Wu

PhD Student

Ram Kannan
Ram Kannan

Research Fellow

Xiaoyi Li
Xiaoyi Li

Postdoctoral Fellow, Jay Shendure Lab, University of Washington, Seattle, WA

Turgut Dogruluk
Turgut Dogruluk

Postdoctoral Fellow

Andrea Ventura, MD, PhD
Andrea Ventura
Rui Gao
Rui Gao

Technical Specialist at Finnegan, Henderson, Farabow, Garrett & Dunner, Washington DC

Kim Huensuk, Research Fellow
Kim Huensuk

Research Fellow

Ji Eun Lee

Postdoc

Chiara Mastroleo, Research Technician, Sr.
Chiara Mastroleo

Research Technician, Sr.

Lab Alumni
Ciro Bonetti, PhD
Ciro Bonetti

Research Fellow

Carla P. Concepcion
Carla P. Concepcion

Postdoctoral Fellow

Joana DeCampos Vidigal, PhD
Joana DeCampos Vidigal

Postdoctoral Fellow

Danilo Maddalo, PhD
Danilo Maddalo

Lab Head, ONC Pharmacology Novartis Institutes for BioMedical Research

Stephanie Cervino
Stephanie Cervino

Administrative Assistant

Yoon-Chi Han, PhD
Yoon-Chi Han

Research Fellow

Francesca Infante
Francesca Infante

Administrative Assistant

Ping Mu
Ping Mu

Graduate Student

Evelyn Yao
Evelyn Yao

Graduate Student

Lab Affiliations

Lab News & Events

Upcoming event

MYC drives SCLC plasticity and metabolic evolution

Memorial Sloan Kettering Cancer Center
Zuckerman Research Center
417 East 68th Street
ZRC Auditorium
New York, NY 10065

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

Career Opportunities

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Research Technician position

We are looking for a research technician to help our investigations of the roles of non coding RNAs in cancer and development.

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Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Andrea Ventura discloses the following relationships and financial interests:

  • Editas
    Ownership / Equity Interests

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2021 through disclosure submission in spring 2022). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].


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