Cancer Biology & Genetics Program

The Andrea Ventura Lab

Research

Andrea Ventura, MD, PhD

One of the most exciting discoveries of the last two decades has been the identification of a large number of non-coding RNAs and the realization that they play essential roles in mammalian development and in diseases. Their study and the characterization of their contribution to the pathogenesis of human cancer is the central focus of our group. To learn more about our lab, please visit our blog and webpage at: www.venturalaboratory.com.

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Research Projects

Projects

Featured News

At Work: Cancer Biologist Andrea Ventura

Andrea Ventura’s research is focused on microRNA expression, as he seeks to understand how small RNAs act on genes to promote or suppress cancer.

In the Lab

Disorderly DNA: Researchers Simulate a Common Cause of Lung Cancer

MSK scientists have created a mouse model that replicates a subtype of non-small cell lung cancer caused by a chromosomal rearrangement.

Video

A Look Inside the Geoffrey Beene Cancer Research Center

Watch our scientists discuss how the Geoffrey Beene Center helped Memorial Sloan Kettering establish a progressive approach to modern cancer research.

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Publications Highlights

Davide Pradella, Minsi Zhang, Rui Gao, Melissa A. Yao, Katarzyna M. Gluchowska, Ylenia Cendon-Florez, Tanmay Mishra, Gaspare La Rocca, Moritz Weigl, Ziqi Jiao, Hieu H. M. Nguyen, Marta Lisi, Mateusz M. Ozimek, Chiara Mastroleo, Kevin Chen, Felix Grimm, Jens Luebeck, Shu Zhang, Andrea Alice Zolli,Eric G. Sun,Bhargavi Dameracharla,Zhengqiao Zhao,Yuri Pritykin, Carlie Sigel and Andrea Ventura Engineered extrachromosomal oncogene amplifications promote tumorigenesis.Nature(2024). https://doi.org/10.1038/s41586-024-08318-8

Li X., Pritykin Y., Concepcion C.P., Lu Y., La Rocca G., Zhang M., King B., Cook P.J., Au Y. W., Popow O., Paulo J.A., Otis G.A., Mastroleo C., Ogrodowski P., Schreiner R., Haigis K.M., Betel D., Leslie C.S., Ventura A. High-Resolution In Vivo Identification of miRNA Targets by Halo-Enhanced Ago2 Pull-Down Molecular Cell, June 3, 2020 https://doi.org/10.1016/j.molcel.2020.05.009 PMID:32497493

Perez AR, Pritykin Y, Vidigal JA, Chhangawala S, Zamparo L, Leslie CS, Ventura A. GuideScan software for improved single and paired CRISPR guide RNA design. Nat Biotechnol. 2017 Mar 6. doi: 10.1038/nbt.3804. [Epub ahead of print] PMID: 28263296

Han YC, Vidigal JA, Mu P, Yao E, Singh I, González AJ, Concepcion CP, Bonetti C, Ogrodowski P, Carver B, Selleri L, Betel D, Leslie C, Ventura A. An allelic series of miR-17～92-mutant mice uncovers functional specialization and cooperation among members of a microRNA polycistron. Nat Genet. 2015 Jun 1. doi: 10.1038/ng.3321. [Epub ahead of print] PubMed PMID: 26029871.

Danilo Maddalo, Eusebio Manchado, Carla P. Concepcion, Ciro Bonetti, Joana A. Vidigal, Yoon-Chi Han, Paul Ogrodowski, Alessandra Crippa, Natasha Rekhtman, Elisa de Stanchina, Scott W. Lowe, and Andrea Ventura. In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system. Nature. 2014 Oct 22.

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People

Andrea Ventura, MD, PhD

Cancer biologist Andrea Ventura studies non-coding RNAs in cancer and development
MD, Catholic University of Rome (Italy)
PhD, European Institute of Oncology (Milan Italy), Open University (London, UK)
Postdoctoral, Center for Cancer Research, Massachusetts Institute of Technology (Cambridge, MA)

[email protected]: Email Address
646-888-3068: Office Phone
Download CV: PDF File

Members

Chiara Mastroleo, Research Technician, Sr. — Chiara Mastroleo
Research Technician, Sr.

Lab Alumni

Ciro Bonetti, PhD — Ciro Bonetti
Research Fellow

Joana DeCampos Vidigal, PhD — Joana DeCampos Vidigal
Postdoctoral Fellow

Xiaoyi Li
Postdoctoral Fellow, Jay Shendure Lab, University of Washington, Seattle, WA

Danilo Maddalo, PhD — Danilo Maddalo
Lab Head, ONC Pharmacology Novartis Institutes for BioMedical Research

Stephanie Cervino
Administrative Assistant

Rui Gao
Patent Law Clerk at Arnold and Porter Kaye Scholer LLP, Washington, DC

Yoon-Chi Han, PhD — Yoon-Chi Han
Research Fellow

Kim Huensuk, Research Fellow — Kim Huensuk
Research Fellow

Francesca Infante
Administrative Assistant

Lab Affiliations

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs

Career Opportunities

Apply now

Research Technician position

We are looking for a research technician to help our investigations of the roles of non coding RNAs in cancer and development.

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Get in Touch

[email protected]

Lab Head Email
646-888-3068

Office Phone
646-422-0871

Office Fax
646-888-3069

Lab Phone
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Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Andrea Ventura discloses the following relationships and financial interests:

Editas
Equity

The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2023 through disclosure submission in spring 2024). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].

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