The Andrea Ventura Lab: Projects

We have generated several mouse models where we can spatiotemporally induce ecDNA formation of Myc, Mdm2, and other oncogenes commonly found as ecDNA.

Our lab has developed tools to aid in the generation of guide RNA CRISPR libraries, initially with GuideScan 1.0 (Perez, Pritykin, Vidigal et al., Nature Biotechnology). Since then, we have developed GuideScan 2.0 (Schmidt & Zhang et al., Genome Biology) which is used by labs worldwide.

Our group has pioneered the use the CRISPR-Cas9 technology to engineer chromosomal rearrangements in vivo.

Our work over the past decade has contributed to the detailed genetic and phenotypic characterization of the miR-17~92 and miR-34 families of miRNAs.