The Andrea Ventura Lab: Publications


View a full listing of Andrea Ventura’s journal articles.

Bonetti P, Climent M, Panebianco F, Tordonato C, Santoro A, Marzi MJ, Pelicci PG, Ventura A, Nicassio F.
Dual role for miR-34a in the control of early progenitor proliferation and commitment in the mammary gland and in breast cancer. 
Oncogene. 2018 Aug 9. doi: 10.1038/s41388-018-0445-3. [Epub ahead of print] PubMed PMID: 30093634.

Zheng J, Sadot E, Vigidal JA, Klimstra DS, Balachandran VP, Kingham TP, Allen PJ, D’Angelica MI, DeMatteo RP, Jarnagin WR, and Ventura A.
Characterization of hepatocellular adenoma and carcinoma using microRNA profiling and targeted gene sequencing. 
PLoS One. 2018 Jul 27;13(7):e0200776. doi: 10.1371/journal.pone.0200776. eCollection 2018. PubMed PMID: 30052636; PubMed Central PMCID: PMC6063411.

Schaub FX, Dhankani V, Berger AC, Trivedi M, Richardson AB, Shaw R, Zhao W, Zhang X, Ventura A, Liu Y, Ayer DE, Hurlin PJ, Cherniack AD, Eisenman RN, Bernard B, Grandori C; Cancer Genome Atlas Network. (2018)
Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas. 
Cell Syst. 2018 Mar 28;6(3):282-300.e2. doi: 10.1016/j.cels.2018.03.003. PubMed PMID: 29596783.

Ventura, A., and Dow, L. (2018)
Modeling Cancer in the CRISPR Era.
Annual Review of Cancer Biology Vol 2. Issue 1

Cook PJ, Thomas R, Kannan R, de Leon ES, Drilon A, Rosenblum MK, Scaltriti M,  Benezra R, Ventura A. Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic targetNat Commun. 2017 Jul 11;8:15987.
doi: 10.1038/ncomms15987. PubMed PMID: 28695888; PubMed Central PMCID:

Perez AR, Pritykin Y, Vidigal JA, Chhangawala S, Zamparo L, Leslie CS, Ventura A. GuideScan software for improved single and paired CRISPR guide RNA design. Nat Biotechnol. 2017 Mar 6. doi: 10.1038/nbt.3804. [Epub ahead of print] PMID: 28263296

Maddalo D, Ventura A. Somatic Engineering of Oncogenic Chromosomal Rearrangements: A Perspective. Cancer Res. 2016 Aug 12. [Epub ahead of print]
Review. PubMed PMID: 27520450.

Li X, Wu R, Ventura A. The present and future of genome editing in cancer research. Hum Genet. 2016 Jul 18. [Epub ahead of print] Review. PubMed PMID:

Ventura A. NORAD: Defender of the Genome. Trends Genet. 2016 Jul;32(7):390-2. doi: 10.1016/j.tig.2016.04.002. Epub 2016 May 5. PubMed PMID: 27157388.[PMID: 27157388].

Kannan R, Ventura A. The CRISPR revolution and its impact on cancer research. Swiss Med Wkly. 2015 Dec 10;145:w14230. doi: 10.4414/smw.2015.14230. eCollection  2015. PubMed PMID: 26661454.

Vidigal JA, Ventura A. Rapid and efficient one-step generation of paired gRNA CRISPR-Cas9 libraries. Nat Commun. 2015 Aug 17;6:8083. doi: 10.1038/ncomms9083.

Han YC, Vidigal JA, Mu P, Yao E, Singh I, González AJ, Concepcion CP, Bonetti C, Ogrodowski P, Carver B, Selleri L, Betel D, Leslie C, Ventura A. An allelic series of miR-17~92-mutant mice uncovers functional specialization and cooperation among members of a microRNA polycistron. Nat Genet. 2015 Jun 1. doi: 10.1038/ng.3321. [Epub ahead of print] PubMed PMID: 26029871.

Fiori E, Babicola L, Andolina D, Coassin A, Pascucci T, Patella L, Han YC, Ventura A, Ventura R.Neurobehavioral Alterations in a Genetic Murine Model of Feingold Syndrome 2. Behav Genet. 2015 May 31. [Epub ahead of print] PubMed PMID: 26026879.

La Rocca G, Olejniczak SH, González AJ, Briskin D, Vidigal JA, Spraggon L, DeMatteo RG, Radler MR, Lindsten T, Ventura A, Tuschl T, Leslie CS, Thompson CB.  In vivo, Argonaute-bound microRNAs exist predominantly in a reservoir of low molecular weight complexes not associated with mRNA. Proc Natl Acad Sci U S A. 2015 Jan 7. pii: 201424217. [Epub ahead of print] PubMed PMID: 26029871.

Joana A. VIdigal and Andrea Ventura. The biological functions of miRNAs: lessons from in vivo studies. Trends in Cell Biology. 2014 Dec 4.

Danilo Maddalo, Eusebio Manchado, Carla P. Concepcion, Ciro Bonetti, Joana A. Vidigal, Yoon-Chi Han, Paul Ogrodowski, Alessandra Crippa, Natasha Rekhtman, Elisa de Stanchina, Scott W. Lowe, and Andrea Ventura. In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system. Nature. 2014 Oct 22.

Frederique Zindy, Daisuke Kawauchi, Youngsoo Lee, Olivier Ayrault, Leila Ben Merzoug, Peter J. McKinnon, Andrea Ventura,  and Martine F. Roussel. Role of the miR-17 approximately 92 cluster family in cerebellar and medulloblastoma development. Biol Open 3, 597-605 (2014). PMCID: PMC4154296

Concepcion CP, Han YC, Mu P, Bonetti C, Yao E, D’Andrea A, Vidigal JA, Maughan WP, Ogrodowski P, Ventura A. Intact p53-Dependent Responses in miR-34-Deficient Mice. PLoS Genet. 2012 Jul; 8 (7) :e1002797.

Alves Vidigal J, Ventura A. Embryonic stem cell miRNAs and their roles in development and disease. Semin Cancer Biol. 2012 May 4;

Concepcion CP, Bonetti C, Ventura A. The microRNA-17-92 family of microRNA clusters in development and disease. Cancer J. 2012 May-Jun; 18 (3) :262-7.

Agostini M, Tucci P, Steinert JR, Shalom-Feuerstein R, Rouleau M, Aberdam D, Forsythe ID, Young KW, Ventura A, Concepcion CP, Han YC, Candi E, Knight RA, Mak TW, Melino G. microRNA-34a regulates neurite outgrowth, spinal morphology, and function. Proc Natl Acad Sci U S A. 2011 Dec 27; 108 (52) :21099-104.

Lal A, Thomas MP, Altschuler G, Navarro F, O’Day E, Li XL, Concepcion C, Han YC, Thiery J, Rajani DK, Deutsch A, Hofmann O, Ventura A, Hide W, Lieberman J. Capture of microRNA-bound mRNAs identifies the tumor suppressor miR-34a as a regulator of growth factor signaling. PLoS Genet. 2011 Nov; 7 (11) :e1002363.

de Pontual L, Yao E, Callier P, Faivre L, Drouin V, Cariou S, Van Haeringen A, Geneviève D, Goldenberg A, Oufadem M, Manouvrier S, Munnich A, Vidigal JA, Vekemans M, Lyonnet S, Henrion-Caude A, Ventura A, Amiel J. Germline deletion of the miR-17∼92 cluster causes skeletal and growth defects in humans. Nat Genet. 2011 Sep 4; 43 (10) :1026-30.

Sage J, Ventura A. miR than meets the eye. Genes Dev. 2011 Aug 15; 25 (16) :1663-7.

Yang JS, Phillips MD, Betel D, Mu P, Ventura A, Siepel AC, Chen KC, Lai EC. Widespread regulatory activity of vertebrate microRNA* species. RNA. 2011 Feb; 17 (2) :312-26.

Yao E, Ventura A. A new role for miR-182 in DNA repair. Mol Cell. 2011 Jan 21; 41 (2) :135-7.

Mu P, Han YC, Betel D, Yao E, Squatrito M, Ogrodowski P, de Stanchina E, D’Andrea A, Sander C, Ventura A. Genetic dissection of the miR-17~92 cluster of microRNAs in Myc-induced B-cell lymphomas. Genes Dev. 2009 Dec 15; 23 (24) :2806-11.  

Ventura A, Jacks T. MicroRNAs and cancer: short RNAs go a long way. Cell. 2009 Feb 20; 136 (4) :586-91.

Ventura A, Young AG, Winslow MM, Lintault L, Meissner A, Erkeland SJ, Newman J, Bronson RT, Crowley D, Stone JR, Jaenisch R, Sharp PA, Jacks T. Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell. 2008 Mar 7; 132 (5) :875-86.

Ventura A, Kirsch DG, McLaughlin ME, Tuveson DA, Grimm J, Lintault L, Newman J, Reczek EE, Weissleder R, Jacks T. Restoration of p53 function leads to tumour regression in vivo. Nature. 2007 Feb 8; 445 (7128) :661-5. [PMID:17251932].