Madhavi Lakkaraja, MD, MPH

Research Fellow
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Madhavi Lakkaraja MD, MPH is currently an assistant professor in pediatric stem cell transplant/cellular therapies at Fred Hutchinson Cancer Center/ University Washington School of Medicine/Seattle Children’s Hospital. She completed her pediatric hematology oncology fellowship at Memorial Sloan/Kettering Cancer Center/ Weill Cornell Medicine and then did a pediatric stem cell transplant/cellular therapies fellowship at Texas Children’s Hospital/Baylor College of Medicine.

Her research work is focused on developing personalized approaches to transplant and cellular therapies to have good outcomes with minimal side effects.

Publications

Selected publications and presentations:

Papers

Lakkaraja M, Scordo M, Mauguen A, Cho C, Devlin S, Ruiz JD, Klein E, Avecilla ST, Boulad F, Cancio MI, Curran KJ, Jakubowski AA, Kernan NA, Kung AL, O’Reilly RJ, Papadopoulos EB, Prockop S, van Roessel I, Scaradavou A, Shaffer BC, Shah G, Spitzer B, Tamari R, Giralt SA, Perales MA, Boelens JJ. Antithymocyte globulin exposure in CD34+ T-cell-depleted allogeneic hematopoietic cell transplantation. Blood Adv. 2022 Feb 8;6(3):1054-1063. doi: 10.1182/bloodadvances.2021005584. PMID: 34788361; PMCID: PMC8945304.

Oral Presentations

Lakkaraja M., Mauguen A., Boulad F., Cancio M.I., Curran K.J., Harris A., Kernan N.A., Klein E., Kung A.L., Oved J.H., Prockop S., Scaradavou A., Spitzer B., O’Reilly R.J., Boelens J.J. “Impact of Rabbit Anti-Thymocyte Globulin (rATG) Exposure in Ex Vivo T-Cell Depleted Hematopoietic Cell Transplantation in Children and Young Adults”. Oral Presentation: 2023 Tandem Meetings Transplantation & Cellular Therapy Meetings of ASTCT and CIBMTR, Orlando, Florida, February 2023.

Lakkaraja M., Hosszu K., McAvoy D., Mauguen A., Purdon T.J., Khakoo Y., Santomasso B.D., Riviere I., Sadelain M., Curran K.J., Park J.H., Brentjens R.J., Boelens J.J. Decreased neuroprotective analytes on day of infusion of chimeric antigen receptor (car) T cells are associated with neurotoxicity. Oral Presentation: 47th Annual Meeting of the European Society for Blood and Marrow Transplantation (EBMT), March 2021.

Lakkaraja, M., Mauguen, A., Boulad, F., Spitzer, B., Scaradavou, A., Curran, K.J., Cancio, M.I., Roessel, I., Klein, E., Kernan, N.A., O’Reilly, R., Prockop, S. and Boelens, J.J. “Rabbit Anti-Thymocyte Globulin (ATG) Exposure after Ex Vivo T-Cell Depleted Hematopoietic Cell Transplantation Is Variable and Impacts Immune Reconstitution and Survival in Pediatric and Young Adult Patients.” Oral Presentation: 46th Annual Meeting of the European Society for Blood and Marrow Transplantation, August 2020.

Posters

Lakkaraja M., Hosszu K., McAvoy D., Mauguen A., Purdon T.J., Khakoo Y., Santomasso B.D., Senechal B.,Riviere I., Sadelain M., Curran K.J., Park J.H., Brentjens R.J., Boelens J.J.. Discovery Proteomics for Analytes to predict Cytokine Release Syndrome on Day of Infusion of Chimeric Antigen Receptor (CAR) T cells. Poster presentation: International Society for Cell & Gene Therapy (ISCT) 2022, San Francisco, May 2022.

Lakkaraja M., Hosszu K., McAvoy D., Mauguen A., Purdon T.J., Khakoo Y., Santomasso B.D., Senechal B.,Riviere I., Sadelain M., Curran K.J., Park J.H., Brentjens R.J., Boelens J.J.. Predictors for Neurotoxicity on Day of Infusion of Chimeric Antigen Receptor (CAR) T cells using Discovery Proteomics Platform. Late Breaking abstract. Poster presentation: International Society for Cell & Gene Therapy (ISCT) 2021, May 2021  

Lakkaraja, M., Scordo, M., Mauguen, A., Cho C., Devlin S., Avecilla S., Boulad F., Cancio, M., Curran, K., Jakubowski, A., Kernan N, Kung A., O’Reilly R., Papadopoulos E., Prockop S., Roessel I., Ruiz J., Scaradavou, A., Shaffer B., Shah G., Spitzer B., Tamari R., Giralt S., Perales MA, Boelens JJ. Rabbit Anti-Thymocyte Globulin Exposure (rATG) in CD34+ Selected Hematopoietic Cell Transplantation and Its Impact on Immune Reconstitution and Outcomes in Children and Adults. Poster presentation: 2020 American Society of Hematology (ASH) December 5, 2020.

Lakkaraja, M., Mauguen, A., Boulad, F., Spitzer, B., Scaradavou, A., Curran, K.J., Cancio, M.I., Roessel, I., Kernan, N.A., O’Reilly, R., Prockop, S. and Boelens, J.J. Rabbit Anti-Thymocyte Globulin (ATG) Exposure after Ex Vivo T-Cell Depleted Hematopoietic Cell Transplantation Is Highly Variable and Impacts Immune Reconstitution in Pediatric and Young Adult Patients. Poster presentation: 2020 Transplantation and Cellular Therapy Meetings of American Society of ASTCT and the CIBMTR. February 19, 2020, Orlando, Florida.