Wei-Feng Yen

Graduate Student

Wei-Feng Yen

Graduate Student
Wei-Feng Yen

Start Year


End Year



MS, National Taiwan University


First Author Publications

Yen, W.-F., Sharma, R., Cols, M., Lau, C. M., Chaudhry, A., Chowdhury, P., Yewdell, W. T., Vaidyanathan, B., Sun, A., Coffre, M., Pucella, J. N., Chen, C.-C., Jasin, M., Sun, J. C., Rudensky, A. Y., Koralov, S. B., & Chaudhuri, J. (2019). Distinct Requirements of CHD4 during B Cell Development and Antibody Response. Cell Reports, 27(5), 1472-1486.e5. https://doi.org/10.1016/j.celrep.2019.04.011
Yen, W.-F., Chaudhry, A., Vaidyanathan, B., Yewdell, W. T., Pucella, J. N., Sharma, R., Liang, Y., Li, K., Rudensky, A. Y., & Chaudhuri, J. (2017). BRCT-domain protein BRIT1 influences class switch recombination. Proceedings of the National Academy of Sciences of the United States of America, 114(31), 8354–8359. https://doi.org/10.1073/pnas.1708211114

Contributing Author Publications

Sharma, R., Smolkin, R. M., Chowdhury, P., Fernandez, K. C., Kim, Y., Cols, M., Alread, W., Yen, W.-F., Hu, W., Wang, Z.-M., Violante, S., Chaligné, R., Li, M. O., Cross, J. R., & Chaudhuri, J. (2023). Distinct metabolic requirements regulate B cell activation and germinal center responses. Nature Immunology, 24(8), 1358–1369. https://doi.org/10.1038/s41590-023-01540-y
Fernandez, K. C., Feeney, L., Smolkin, R. M., Yen, W.-F., Matthews, A. J., Alread, W., Petrini, J. H. J., & Chaudhuri, J. (2022). The structure-selective endonucleases GEN1 and MUS81 mediate complementary functions in safeguarding the genome of proliferating B lymphocytes. eLife, 11, e77073. https://doi.org/10.7554/eLife.77073
Yewdell, W. T., Kim, Y., Chowdhury, P., Lau, C. M., Smolkin, R. M., Belcheva, K. T., Fernandez, K. C., Cols, M., Yen, W.-F., Vaidyanathan, B., Angeletti, D., McDermott, A. B., Yewdell, J. W., Sun, J. C., & Chaudhuri, J. (2020). A Hyper-IgM Syndrome Mutation in Activation-Induced Cytidine Deaminase Disrupts G-Quadruplex Binding and Genome-wide Chromatin Localization. Immunity, 53(5), 952-970.e11. https://doi.org/10.1016/j.immuni.2020.10.003
Nicolas, L., Cols, M., Smolkin, R., Fernandez, K. C., Yewdell, W. T., Yen, W.-F., Zha, S., Vuong, B. Q., & Chaudhuri, J. (2019). Cutting Edge: ATM Influences Germinal Center Integrity. Journal of Immunology (Baltimore, Md.: 1950), 202(11), 3137–3142. https://doi.org/10.4049/jimmunol.1801033
Pucella, J. N., Cols, M., Yen, W.-F., Xu, S., & Chaudhuri, J. (2019). The B Cell Activation-Induced miR-183 Cluster Plays a Minimal Role in Canonical Primary Humoral Responses. Journal of Immunology (Baltimore, Md.: 1950), 202(5), 1383–1396. https://doi.org/10.4049/jimmunol.1800071
Chen, C.-C., Kass, E. M., Yen, W.-F., Ludwig, T., Moynahan, M. E., Chaudhuri, J., & Jasin, M. (2017). ATM loss leads to synthetic lethality in BRCA1 BRCT mutant mice associated with exacerbated defects in homology-directed repair. Proceedings of the National Academy of Sciences of the United States of America, 114(29), 7665–7670. https://doi.org/10.1073/pnas.1706392114
DiMenna, L. J., Yen, W.-F., Nicolas, L., Sharma, R., Saldanha, Z. N., & Chaudhuri, J. (2017). Cutting Edge: The Transcription Factor Sox2 Regulates AID Expression in Class-Switched B Cells. Journal of Immunology, 198(6), 2244–2248. https://doi.org/10.4049/jimmunol.1502266
Vaidyanathan, B., Chaudhry, A., Yewdell, W. T., Angeletti, D., Yen, W.-F., Wheatley, A. K., Bradfield, C. A., McDermott, A. B., Yewdell, J. W., Rudensky, A. Y., & Chaudhuri, J. (2017). The aryl hydrocarbon receptor controls cell-fate decisions in B cells. The Journal of Experimental Medicine, 214(1), 197–208. https://doi.org/10.1084/jem.20160789
Pucella, J. N., Yen, W.-F., Kim, M. V., van der Veeken, J., Luo, C. T., Socci, N. D., Naito, Y., Li, M. O., Iwai, N., & Chaudhuri, J. (2015). miR-182 is largely dispensable for adaptive immunity: Lack of correlation between expression and function. Journal of Immunology, 194(6), 2635–2642. https://doi.org/10.4049/jimmunol.1402261
Vaidyanathan, B., Yen, W.-F., Pucella, J. N., & Chaudhuri, J. (2014). AIDing Chromatin and Transcription-Coupled Orchestration of Immunoglobulin Class-Switch Recombination. Frontiers in Immunology, 5, 120. https://doi.org/10.3389/fimmu.2014.00120

View a full listing of Wei-Feng Yen’s journal articles.