Cell Biology Program
The Michael Overholtzer Lab
The Overholtzer lab studies mechanisms of nutrient sensing and cellular responses to nutrient starvation, including the nutrient recycling pathway autophagy, scavenging pathways such as macropinocytosis, and mechanisms of cell death. We investigate cell death mechanisms that have unique effects on cell populations, including entosis that supports the survival of starved cells and promotes cell competition, and ferroptosis that eliminates starved cell populations by propagating from cell to cell. The lab also studies mechanisms that regulate autophagy protein and lysosome function in endocytic trafficking and nutrient homeostasis.
Bandyopadhyay U, Todorova P, Pavlova NN, Tada Y, Thompson CB, Finley L, Overholtzer M. (2022) Leucine retention in lysosomes is regulated by starvation. Proc Natl Acad Sci USA. Feb 8;119(6):e2114912119.
Hayashi A, Fan J, Chen R, Ho YJ, Makohon-Moore AP, Lecomte N, Zhong Y, Hong J, Huang J, Sakamoto H, Attiyeh MA, Kohutek ZA, Zhang L, Boumiza A, Kappagantula R, Baez P, Bai J, Lisi M, Chadalavada K, Melchor JP, Wong W, Nanjangud GJ, Basturk O, O’Reilly EM, Kimstra DS, Hruban RH, Wood LD, Overholtzer M, Iacobuzio-Donahue CA (2022) A unifying paradigm for transcriptional heterogeneity and squamous features in pancreatic ductal adenocarcinoma. Nat Cancer. Feb 2.
Riegman M, Sagie L, Galed C, Levin T, Steinberg N, Dixon SJ, Wiesner U, Brandbury MS, Niethammer P, Zaritsky A, Overholtzer M. (2020) Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture. Nat Cell Biol. Sep 22; (9):1042-1048.
Katikaneni A, Jelcic M, Gerlach GF, Ma Y, Overholtzer M, Niethammer P. (2020) Lipid peroxidation regulates long-range wound detection through 5-lipoxygenase in zebrafish. Nat Cell Biol. Sep 22;(9):1049-1055.
Michael Overholtzer, PhD
Dean, Gerstner Sloan Kettering Graduate School
- Cell biologist Michael Overholtzer studies the mechanisms of tumor initiation and progression, cell adhesion, and cell death.
- PhD, Princeton University
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Michael Overholtzer discloses the following relationships and financial interests:
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