Cell Biology Program
The Michael Overholtzer Lab
The Overholtzer lab studies mechanisms of nutrient sensing and cellular responses to nutrient starvation, including the nutrient recycling pathway autophagy, scavenging pathways such as macropinocytosis, and mechanisms of cell death. We investigate cell death mechanisms that have unique effects on cell populations, including entosis that supports the survival of starved cells and promotes cell competition, and ferroptosis that eliminates starved cell populations by propagating from cell to cell. The lab also studies mechanisms that regulate autophagy protein and lysosome function in endocytic trafficking and nutrient homeostasis.
Zaritsky A, Tseng YY, Rabadán MA, Krishna S, Overholtzer M*, Danuser G*, Hall A. (2017) Diverse roles of guanine nucleotide exchange factors in regulating collective cell migration. *co-corresponding authors. J Cell Biol. Jun 5;216(6):1543-1556.
Kim SE, Zhang L, Ma K, Riegman M, Chen F,Ingold I, Conrad M, Gao M, Jiang X, Monette S, Mohan P, Chen F, GonenM, Zanzonico P, Quinn T, Wiesner U, Bradbury MS, Overholtzer M.(2016) Ultrasmall Nanoparticles Induce Ferroptosis of Nutrient-Deprived Cancer Cells and Suppress Tumor Growth. Nat Nanotechnol. Nov;11(11):977-985.
Michael Overholtzer, PhD
Dean, Gerstner Sloan Kettering Graduate School
- Cell biologist Michael Overholtzer studies the mechanisms of tumor initiation and progression, cell adhesion, and cell death.
- PhD, Princeton University
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Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
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Michael Overholtzer discloses the following relationships and financial interests:
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