My lab studies the mechanisms governing transgene expression, stem cell engineering, and genetic strategies to enhance immunity against cancer.
Michel Sadelain, MD, PhD
Director, Center for Cell Engineering
Professor
Research Focus
Immunologist Michel Sadelain studies the mechanisms governing transgene expression, stem cell engineering, and genetic strategies to enhance immunity against cancer.Education
- MD, University of Paris
- PhD, University of Alberta
- Office Phone: 212-639-6190
- Office Fax: 917-432-2340
- Lab Phone: 212-639-6170
- Lab Fax: 917-432-2340
Lab Members
Diana Buchman
Administrative Assistant
Annalisa Cabriolu
Research Fellow
Anton Dobrin
Graduate Student
Justin Eyquem
Research Fellow
Judith C. Feucht
Research Fellow
Theodoros Giavridis
Graduate Student
Gertrude Gunset
Senior Research Technician
Mohamad Hamieh
Research Fellow
Sascha Haubner
Visiting Investigator
Nayan Jain
Graduate Student
Jorge Mansilla-Soto
Research Fellow
Ashlesha Odak
Graduate Student
Karlo Perica
Medical Oncology Fellow
Fabiana Perna
Senior Research Scientist
Maria Lemdal Sjostrand
Visiting Investigator
Sjoukje Van der Stegen
Research Fellow
Zeguo Zhao
Senior Research Scientist
Publications
- Davila ML, Riviere I, Wang X, Bartido S, Park J, Curran K, Chung SC, Stefanski J, Borquez-Ojeda O, Olszewska M, Qu J, Wasielewska T, He W, Fink M, Shinglot H, Youssif M, Satter M, Wang Y, Hosey J, Quintanilla H, Halton E, Bernal Y, Bouhassira DCG, Arcila ME, Gonen M, Roboz GJ, Maslak P, Douer D, Frattini MG, Giralt S, Sadelain M, Brentjens R. Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia. Sci Transl Med 19 February 2014. Vol. 6, Issue 224, p. 224ra25. DOI: 10.1126/scitranslmed.3008226.
- Fedorov VD, Themeli M, Sadelain M. PD-1- and CTLA-4-Based Inhibitory Chimeric Antigen Receptors (iCARs) Divert Off-Target Immunotherapy Responses. Sci Transl Med. 2013 Dec 11;5(215):215ra172. doi: 10.1126/scitranslmed.3006597.
Selected Achievements
- Cited in Science magazine "Breakthrough of the Year: Cancer Immunology” (2013)
- Sultan Bin Khalifa International Thalassemia Awards (SITA) International Award for Innovative Medical Research on Thalassemia (2013)
- Elected to Vice President of the American Society for Gene and Cell Therapy (Vice President 2013, President Elect 2014, President 2015)
- Antonio Cao Award for Research in Thalassemia or Hemoglobinopathies, Palermo, Italy (2013)
- Recipient of the Coley Award of the Cancer Research Institute for Distinguished Research in Tumor Immunology (shared with Carl June, University of Pennsylvania) (2012)
