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Group Meeting Papers 2010

Here is a list of research papers that were presented for discussion in our 2010 weekly group meetings. Papers are selected by group members as a means to broaden our knowledge in chemistry and chemical biology.


13 Dec 2010, presented by Renato Bauer
A bacterium that can grow by using arsenic instead of phosphorus.
Wolfe-Simon, F.*; Switzer Blum, J.; Kulp, T. R.; Gordon, G. W.; Hoeft, S. E.; Pett-Ridge, J.; Stolz, J. F.; Webb, S. M.; Weber, P. K.; Davies, P. C. W.; Anbar, A. D.; Oremland, R. S. Science 2011, 332, 1163-1166.
[ Abstract ]

30 Nov 2010, presented by Felix Kopp
Gold-catalyzed oxidative ring-expansions and ring-cleavages of alkynylcyclopropanes by intermolecular reactions oxidized by diphenylsulfoxide.
Li, C.-W.; Pati, K.; Lin, G.-Y.; Abu Sohel, S. M.; Hung, H.-H.; Liu, R.-S.* Angew. Chem. Intl. Ed. 2010, 49, 9891-9894.
[ Abstract ]

25 Oct 2010, presented by Jeff Rothman
Evaluation of biologically relevant short α-helices stabilized by a main-chain hydroben-bond surrogate.
Wang, D.; Chen, K.; Kulp III, J. L.; Arora, P. S.* J. Am. Chem. Soc. 2006, 128, 9248-9256.
[ Abstract ]

11 Oct 2010, presented by Tony Davis
Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli.
Ajikumar, P. K.; Xiao, W.-H.; Tyo, K. E. J.; Wang, Y.; Simeon, F.; Leonard, E.; Mucha, O.; Phon, T. H.; Pfeifer, B.*; Stephanopoulos, G.* Science 2010, 330, 70-74.
[ Abstract ]

27 Sep 2010, presented by Debarshi Pratihar
Umpolung reactivity in amide and peptide synthesis.
Shen, B.; Makley, D. M.; Johnston, J. N.* Nature 2010, 465, 1027-1032.
[ Abstract ]

7 Sep 2010, presented by Gustavo Moura-Letts
Cyano Diels−Alder and cyano ene reactions. Applications in a formal [2 + 2 + 2] cycloaddition strategy for the synthesis of pyridines.
Sakai, T.; Danheiser, R. L.* J. Am. Chem. Soc. 2010, 132, 13203-13205.
[ Abstract ]

9 Aug 2010, presented by Chris Stratton
Antibiotics as signalling molecules.
Yim, Y.; Huimi Wang, H.; Davies, J.* Phil. Trans. R. Soc. B 2007, 362, 1195-1200.
[ Abstract ]

27 Jul 2010, presented by Jackie Wurst
Distinct biological network properties between the targets of natural products and disease genes.
Dančík, V.; Petri Seller, K.; Young, D. W.; Schreiber, S. L.*; Clemons, P. A.* J. Am. Chem. Soc. 2010, 132, 9259-9261.
[ Abstract ]

13 Jul 2010, presented by Renato Bauer
Stereochemical and skeletal diversity arising from amino propargylic alcohols.
Pizzirani, D.; Kaya, T.; Clemons, P. A.; Schreiber, S. L.* Org. Lett. 2010, 12, 2822-2825.
[ Abstract ]

31 May 2010, presented by Felix Kopp
Cross-coupling reactions through the intramolecular actviation of alkyl(triorgano)silanes.
Nakao, Y.; Takeda, M.; Matsumoto, T.; Hiyama, T.* Angew. Chem. Intl. Ed. 2010, 49, 4447-4450.
[ Abstract ]

17 May 2010, presented by Tony Davis
Facile, template-free synthesis of stimuli-responsive polymer nanocapsules for targeted drug delivery.
Kim, E.; Kim, D.; Jung, H.; Lee, J.; Paul, S.; Selvapalam, N.; Yang, Y.; Lim, N.; Park, C. G.; Kim, K.* Angew. Chem. Intl. Ed. 2010, 23, 4405-4408.
[ Abstract ]

3 May 2010, presented by Debarshi Pratihar
Scalable catalytic asymmetric Strecker syntheses of unatural α-amino acids.
Zuend, S. J.; Coughlin, M. P.; Lalonde, M. P.; Jacobsen, E. N.* Nature 2009, 461, 968-970.
[ Abstract ]

14 Apr 2010, presented by Gustavo Moura-Letts
Multistep phase-switch synthesis by using liquid-liquid partitioning of boronic acids: Productive tags with an expanded repertoire of compatible reactions.
Mothana, S.; Grassot, J.-M.; Hall, D. G.* Angew. Chem. Intl. Ed. 2010, 49, 2883-2887.
[ Abstract ]

30 Mar 2010, presented by Chris Stratton
Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an α-glucan pathway.
[ Abstract ]

15 Mar 2010, presented by Shalini Balakrishnan
Chemical control over immune recognition: A class of antibody-recruiting small molecules that target prostate cancer.
Murelli, R. P.; Zhang, A. X.; Michel, J.; Jorgensen, W. L.; Spiegel, D. A.* J. Am. Chem. Soc. 2009, 131, 17090-17092.
[ Abstract ]

2 Mar 2010, presented by Jackie Wurst
Hydrogenolysis of unstrained carbon-carbon σ bonds: Stereoselective entry into benzylic tertiary centers.
Wilsily, A.; Nguyen, Y.; Fillion, E.* J. Am. Chem. Soc. 2009, 131, 15606-15607.
[ Abstract ]

15 Feb 2010, presented by Renato Bauer
Chemical decay of an antibiotic inverts selection for resistance.
Palmer, A. C.; Angelino, E.; Kishony, R.* Nat. Chem. Biol. 2010, 6, 105-107.
[ Abstract ]

26 Jan 2010, presented by Felix Kop
Efficient synthesis of aryl fluorides.
Anbarasan, P.; Neumann, H.; Beller, M.* Angew. Chem. Intl. Ed. 2010, 49, 2216-2222.
[ Abstract ]

05 Jan 2010, presented by Guodong Liu
Total synthesis of palau’amine.
Seiple, I. B.; Su, S.; Young, I. S.; Lewis, C. A.; Yamaguchi, J.; Baran, P. S.* Angew. Chem. Intl. Ed. 2010, 49, 1095-1098.
[ Abstract ]