Christopher Stratton

Graduate Student

Christopher Stratton


Postdoctoral Fellow, 2012–present
with Prof. Vern L. Schramm
Department of Biochemistry
Albert Einstein College of Medicine

PhD, Weill Cornell Medical College, 2012
Tri-Institutional PhD Program in Chemical Biology

BS, SUNY Stony Brook, 2006

Thesis: The Diversity-Oriented Synthesis of Macrocycles using Oxidative Ring Expansion Reactions, June 27, 2012


  1. Principal component analysis as a tool for library design: A case study investigating natural products, brand-name drugs, natural product-like libraries, and drug-like libraries.
    Wenderski, T. A.; Stratton, C. F.; Bauer, R. A.; Kopp, F.; Tan, D. S.* Methods Mol Biol. 2015, 1263, 225–242.
    Abstract | PubMed ]

  2. A diversity-oriented synthesis approach to macrocycles via oxidative ring expansion.
    Kopp, F.; Stratton, C. F.; Akella, L. B.; Tan, D. S.* Nat. Chem. Biol. 2012, 8, 358–365.
    Abstract | PubMed | PMC ]
    (Highlighted in SciBX )

  3. Mechanism and inhibition of saFabI, the enoyl reductase from Staphylococcus aureus.
    Xu, H.; Sullivan, T. J.; Sekiguchi, J.; Kirikae, T.; Ojima, I.; Stratton, C. F.; Mao, W.; Rock, F. L.; Alley, M. R. K.; Johnson, F.; Walker, S. G.; Tonge, P. J.* Biochemistry 2008, 47, 4228–4236.
    Abstract | PubMed ]

  4. Evidence from Raman spectroscopy that InhA, the mycobacterial enoyl reductase, modulates the conformation of the NADH cofactor to promote catalysis.
    Bell, A. F.; Stratton, C. F.; Zhang, X.; Novichenok, P.; Jaye, A. A.; Nair, P. A.; Parikh, S.; Rawat, R.; Tonge, P. J.* J. Am. Chem. Soc. 2007, 129, 6425–6431.
    Abstract | PubMed ]

  5. Structure of acyl carrier protein bound to FabI, the FASII enoyl reductase from Escherichia coli.
    Rafi, S.; Novichenok, P.; Kolappan, S.; Zhang, X.; Stratton, C. F.; Rawat, R.; Kisker, C.*; Simmerling, C.*; Tonge, P. J.* J. Biol. Chem. 2006, 281, 39285–39293.
    Abstract | PubMed ]

  6. High affinity InhA inhibitors with activity against drug-resistant strains of Mycobacterium tuberculosis.
    Sullivan, T. J.; Truglio, J. J.; Boyne, M. E.; Novichenok, P.; Zhang, X.; Stratton, C. F.; Li, H.-J.; Kaur, T.; Amin, A.; Johnson, F.; Slayden, R. A.*; Kisker, C.*; Tonge, P. J.* ACS Chem. Biol. 2006, 1, 43–53.
    Abstract | PubMed ]