Computational & Systems Biology Program

The Dana Pe'er Lab

Research

Dana Pe'er, PhD
Dana Pe'er, PhD
Chair, Computational and Systems Biology Program, SKI; Scientific Director, Metastasis & Tumor Ecosystems Center

The Pe’er lab combines single cell technologies, genomic datasets and machine learning algorithms to address fundamental questions in biomedical science. Empowered by recent breakthrough technologies like massive parallel single cell RNA-sequencing, we ask questions such as: How do multi-cellular organisms develop from a single cell, resulting in the vast diversity of progenitor and terminal cell types? How does a cell’s regulatory circuit control the dynamics of signal processing and how do these circuits rewire over the course of development? How does an ensemble of cells function together to execute a multi-cellular response, such as an immune response to pathogen or cancer? We will also address more medically oriented questions such as: How do regulatory circuits go awry in disease? What is the consequence of intra-tumor heterogeneity? Can we characterize the tumor immune eco-system to gain a better understanding of when or why immunotherapy works or does not work? A key goal is to use this characterization of the tumor immune eco-system to personalize immunotherapy.

The Dana Pe'er Lab

Publications

The emergent landscape of the mouse gut endoderm at single-cell resolution. Nowotschin S, Setty M, Kuo YY, Liu V, Garg V, Sharma R, Simon CS, Saiz N, Gardner R, Boutet SC, Church DM, Hoodless PA, Hadjantonakis AK, Pe’er D. Nature. 2019 May;569(7756):361-367. doi: 10.1038/s41586-019-1127-1. Epub 2019 Apr 8. PMID: 30959515

Characterization of cell fate probabilities in single-cell data with Palantir. Setty M, Kiseliovas V, Levine J, Gayoso A, Mazutis L, Pe’er D. Nat Biotechnol. 2019 Apr;37(4):451-460. doi: 10.1038/s41587-019-0068-4. PMID: 30899105.

Single-cell map of diverse immune phenotypes in the breast tumor microenvironment. Azizi E, Carr AJ, Plitas G, Cornish AE, Konopacki C, Prabhakaran S, Nainys J, Wu K, Kiseliovas V, Setty M, Choi K, Fromme RM, Dao P, McKenney PT, Wasti RC, Kadaveru K, Mazutis L, Rudensky AY, Pe’er D. Cell. 2018 Aug 23;174(5):1293-1308.e36. doi: 10.1016/j.cell.2018.05.060. PMID: 29961579

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People

Dana Pe'er, PhD

Dana Pe'er, PhD

Chair, Computational and Systems Biology Program, SKI; Scientific Director, Metastasis & Tumor Ecosystems Center

  • Computational Biologist Dana Pe’er combines single cell technologies, genomic datasets and machine learning techniques to address fundamental questions addressing regulatory cell circuits, cellular development, tumor immune eco-system, genotype to phenotype relations and precision medicine.
  • PhD, Hebrew University, Jerusalem Israel
Kingl2@mskcc.org
Email Address

Members

Joseph Chan
Joseph Chan

Thoracic Oncology Fellow

Cassandra Burdziak
Cassandra Burdziak

Graduate Student

Ojasvi Chaudhary
Ojasvi Chaudhary

Research Assistant

Zi-Ning Choo
Zi-Ning Choo

Graduate Student

Tin Yi Chu
Tin Yi Chu

Research Fellow

Jaeyoung Chun
Jaeyoung Chun

Bioinformatics Engineer

Siting Gan
Siting Gan

Research Fellow

Herman Gudjonson
Herman Gudjonson

Postdoctoral Research Fellow

Doron Haviv
Doron Haviv

Graduate Student

Laura King
Laura King

Assistant to the Chair

Vaidotas Kiseliovas
Vaidotas Kiseliovas

Research Scholar

Sanjay Kottapalli
Sanjay Kottapalli

Research Technician

Daniel Li

Graduate Student

Ignas Masilionis
Ignas Masilionis

Senior Research Technician

Linas Mazutis
Linas Mazutis

Associate Lab Member and Director of SCRI

Awni Mousa
Awni Mousa

Senior Bioinformatics Engineer

Tal Nawy
Tal Nawy

Senior Program Manager

Dana Pe'er
Dana Pe'er

Principal Investigator

Sitara Persad
Sitara Persad

Graduate Student

Jose Reyes
Jose Reyes

Postdoctoral Researcher

Alejandro Jimenez Sanchez
Alejandro Jimenez Sanchez

Postdoctoral Research Fellow

Manu Setty
Manu Setty

Research Fellow

Thomas Walle
Thomas Walle

Visiting Scientist

Esther Wershof
Esther Wershof

Research Scholar

Yubin Xie
Yubin Xie

Graduate Student

Tianhao Xu
Tianhao Xu

Senior Research Technician

Lab Alumni
Maria Avdeeva
Maria Avdeeva

Postdoctoral Research Fellow

Elham Azizi
Elham Azizi

Postdoctoral Research Fellow

Ambrose Carr

Visiting Scientist

Kristy Choi

Student

Andrew  Cornish
Andrew Cornish

Graduate Student

Jonathan Fisher
Jonathan Fisher
Vianne Gao
Vianne Gao

Graduate Student

Adam  Gayoso
Adam Gayoso
Pooja Kathail

Student

Ashley Laughney
Ashley Laughney

Postdoctoral Research Fellow

Vincent Lavallée
Vincent Lavallée

Research Scholar

Jacob Levine

Postdoctoral Fellow

Vincent Liu
Vincent Liu

Research Associate

Zakary Plautz

Research Technician

Sandhya Prabhakaran
Sandhya Prabhakaran

Postdoctoral Research Fellow

Kathleen Sadowski

Senior Administrative Assistant

Roshan Sharma
Roshan Sharma

Graduate Student

Lisa Sikkema
Lisa Sikkema

Senior Research Technician

Caitlin Trasande
Caitlin Trasande
Riana Trowell

Administrative Assistant

David van Dijk

Postdoctoral Fellow

Lab Affilations

Achievements

  • 2014 NIH Director’s Pioneer Award
  • 2014 ISCB Overton Prize
  • 2012 RECOMB 2012 Test of Time Award
  • 2010 SU2C AACR Innovator award
  • 2009 Packard Fellowship in Science and Engineering
Read more
  • 2007 NIH Directors New Innovator Award
  • 2005 Runner up for “Breakthrough of the year”, Science Magazine
  • 2005 Career Award at the Interface of Science, Burroughs Welcome Fund

Open Positions

Bioinformatics Engineer II / Computational Research Scientist

We are seeking a developer with a creative and analytical mind to join Sloan Kettering Institute’s Single Cell Research Initiative (SCRI).

Apply now

Senior Research Technician

A driving motivation of the Single Cell Research Initiative (SCRI) is to develop cutting edge single-cell experimental technologies, including single-cell RNA-seq and multi-dimensional imaging, to explore questions in tumor heterogeneity, metastasis and the tumor-immune environment.

Apply now

Get in Touch

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Dana Pe'er discloses the following relationships and financial interests:

No disclosures meeting criteria for time period


The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.


This page and data include information for a specific MSK annual disclosure period (January 1, 2019 through disclosure submission in spring 2020). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.


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