Hayato Iwadare, PhD

Visiting Scientist

Hayato Iwadare

Start Year

2005

End Year

2007

Associate Director, 2011–present
Associate Researcher, 1999–2011
Daiichi Sankyo Co., Ltd., Japan

Visiting Scientist, 2005-2009
Medicinal Chemistry Research Laboratories, Daiichi Sankyo Co., Ltd., Japan

PhD, Tokyo University of Science, 1999

MS, Tokyo University of Science, 1996

BS, Tokyo University of Science, 1994

Japanese Patents: 7

8) Shang, S.; Iwadare, H.; Macks, D. E.; Ambrosini, L. M.; Tan, D. S.* “A unified synthetic approach to polyketides having both skeletal and stereochemical diversity.” Org. Lett. 2007, 9, 1895-1898.

[ Abstract | PDF | Supporting Info | PMC ]
7) Mukaiyama, T.*; Shiina, I.*; Iwadare, H.; Saitoh, M.; Nishimura, T.; Ohkawa, N.; Sakoh, H.; Nishimura, K.; Tani, Y.; Hasegawa, M.; Yamada, K.; Saitoh, K. “Asymmetric total synthesis of Taxol.” Chem. Eur. J. 1999, 5, 121-161.

[ Abstract | PDF ]
6) Mukaiyama, T.*; Shiina, I.*; Iwadare, H.; Sakoh, H.; Tani, Y.; Hasegawa, M.; Saitoh, K. “Asymmetric total synthesis of Taxol.” Proc. Japan Acad., Ser. B. 1997, 73, 95-100.

[ Journal ]
5) Shiiina, I.*; Iwadare, H.; Sakoh, H.; Tani, Y.; Hasegawa, M.; Saitoh, K.; Mukaiyama, T.* “Stereocontrolled synthesis of the BC ring system of Taxol.” Chem. Lett. 1997, 26, 1139-1140.

[ Abstract | PDF ]
4) Yamada, K.; Iwadare, H.; Mukaiyama, T.* “Construction of AB-ring system of taxane framework by A-ring annulation strategy: Synthesis of 1-hydroxy-8,11,11-trimethylbicyclo [5.3.1]undec-7-en-9-one by way of intramolecular aldol cyclization to form the C1-C10 bond.” Chem. Pharmaceut. Bull. 1997, 1898-1905.

[ Journal ]
3) Mukaiyama, T.*; Shiina, I.*; Iwadare, H.; Saitoh, M.; Nishimura, K.; Nishimura, T.; Ohkawa, N.; Sakoh, H.; Saitoh, K. “An asymmetric synthesis of the BC ring system of 8-epitaxoids by way of intramolecular aldol and successive stereoselective methylation reactions.” Chem. Lett. 1996, 25, 483-484.

[ Abstract | PDF ]
2) Shiina, I.*; Iwadare, H.; Saitoh, M.; Ohkawa, N.; Nishimura, T.; Mukaiyama, T.* “An asymmetric synthesis of the fully functionalized AB ring system of 12-demethyltaxol via successive stereoselective allylation and intramolecular aldol reactions.” Chem. Lett. 1995, 24, 781-782.

[ Abstract | PDF ]
1) Mukaiyama, T.*; Shiina, I.*; Kimura, K.; Akiyama, Y.; Iwadare, H. “Synthesis of AB ring model system of Taxol via allylation of 8-membered ring compound and intramolecular aldol condensation.” Chem. Lett. 1995, 24, 229-230.

[ Abstract | PDF ]