Cancer Biology & Genetics Program
The Richard White Lab
Zebrafish models of cancer
The zebrafish has emerged as a new model for studying cancer progression and metastasis. We have developed a transparent strain of zebrafish, called casper, that allows for single-cell imaging of how tumor cells interact with cells in the microenvironment. These cell-cell interactions play fundamental roles in shaping tumor cell behavior. Using a zebrafish model of melanoma, we use state of the art genetic engineering and high-resolution imaging to dissect these interactions. Our goal is to understand the mechanisms that allow tumors to successfully disseminate and take hold in new locations, which is the major cause of cancer mortality.
Baggiolini A+, Callahan SJ+, Trieu T, Tagore MM, Montal E, Weiss JM, Tischfield SE, Fan Y, Campbell NR, Saurat N, Hollmann T, Simon-Vermot T, Tickoo SK, Taylor BS, Koche R, Khurana E, Studer L*, White RM*. +co-authors, *co-corresponding authors. Developmental chromatin programs determine oncogenic competence in melanoma. 2020, in revision, available at https://www.biorxiv.org/content/10.1101/2020.05.09.081554v1.
Weiss JM, Hunter MV, Tagore M, Ma Y, Misale S, Simon-Vermot T, Campbell NR, Newell F, Wilmott JS, Johansson PA, Thompson JF, Long GV, Pearson JV, Mann GJ, Scolyer RA, Waddell N, Montal ED, Huang T, Jonsson P, Donoghue MTA, Harris CC, Taylor BS, Ariyan CE, Solit DB, Wolchok JD, Merghoub T, Rosen N, Hayward NK, White RM. Anatomic position determines oncogenic specificity in melanoma. 2020, in review, available at: https://www.biorxiv.org/content/10.1101/2020.11.14.383083v1
Campbell NR , Zhang M , Baron M , Heilmann S , Deforet M , Ferretti L , Huang TH , Levesque M , Yanai I , Xavier JB*, White RM*, *co-corresponding authors. Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma. 2020, in revision, available at https://www.biorxiv.org/content/10.1101/2020.08.24.265140v1
Hunter MV+, Moncada R+, Weiss JM, Yanai I*, White RM*,+co-authors, *co-corresponding authors. Spatial transcriptomics reveals the architecture of the tumor/microenvironment interface. 2020, in review, available at https://www.biorxiv.org/content/10.1101/2020.11.05.368753v1
Lumaqin D+, Johns E+, Weiss JM, Montal E, Ooladipupo O, Abuhashem A, White RM. An in vivo reporter for tracking lipid droplet dynamics in transparent zebrafish. +co-authors. 2020, in revision, available at https://www.biorxiv.org/content/10.1101/2020.11.09.375667v1
Richard White, MD, PhD
- Cancer biologist and oncologist Richard White uses the zebrafish to dissect interactions between tumor cells and the microenvironment that promote metastasis.
- Albany Medical College: M.D., Ph.D.
- Yale New Haven Hospital: Internal Medicine Residency & Chief Residency
- Dana Farber Cancer Institute & Massachusetts General Hospital: Medical Oncology Fellowship
- Children’s Hospital Boston & Harvard Medical School: Postdoctoral Fellowship
- NIH Directors New Innovator Award
- Young Mentor Award, Melanoma Research Alliance
- Young Investigator Award, American Association for Cancer Research/American Society of Clinical Oncology
- Young Mentor Award, Harvard Medical School
- Outstanding Educator Award, Yale School of Medicine, Department of Internal Medicine
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Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
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Richard White discloses the following relationships and financial interests:
N-of-One Therapeutics, Inc.
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