Cancer Biology & Genetics Program

The Richard White Lab

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Research

Dr. Richard White
Richard White, MD, PhD

Zebrafish models of cancer

The zebrafish has emerged as a new model for studying cancer progression and metastasis. We have developed a transparent strain of zebrafish, called casper, that allows for single-cell imaging of how tumor cells interact with cells in the microenvironment. These cell-cell interactions play fundamental roles in shaping tumor cell behavior. Using a zebrafish model of melanoma, we use state of the art genetic engineering and high-resolution imaging to dissect these interactions. Our goal is to understand the mechanisms that allow tumors to successfully disseminate and take hold in new locations, which is the major cause of cancer mortality.

 

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Richard White Lab

Featured News

Finding
A doctor examines a mole.
Don't Scratch That Mole? Scientists Are Learning More about Inflammation and Cancer

Finding
Large cells filled with yellow-colored fat
Cancer Cells Eat Fat to Grow and Spread

In the Lab
Pictured: Casper zebrafish
Studying Cancer Mysteries Just Beneath the Scales

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Publications

Baggiolini A+, Callahan SJ+, Trieu T, Tagore MM, Montal E, Weiss JM, Tischfield SE, Fan Y,  Campbell NR, Saurat N, Hollmann T, Simon-Vermot T, Tickoo SK, Taylor BS, Koche R, Khurana E, Studer L*, White RM*. +co-authors, *co-corresponding authors. Developmental chromatin programs determine oncogenic competence in melanoma. 2020, in revision, available at https://www.biorxiv.org/content/10.1101/2020.05.09.081554v1.

Weiss JM, Hunter MV, Tagore M, Ma Y, Misale S, Simon-Vermot T, Campbell NR, Newell F, Wilmott JS, Johansson PA, Thompson JF, Long GV, Pearson JV, Mann GJ, Scolyer RA, Waddell N, Montal ED, Huang T, Jonsson P, Donoghue MTA, Harris CC, Taylor BS, Ariyan CE, Solit DB, Wolchok JD, Merghoub T, Rosen N, Hayward NK, White RM. Anatomic position determines oncogenic specificity in melanoma. 2020, in review, available at: https://www.biorxiv.org/content/10.1101/2020.11.14.383083v1

Campbell NR , Zhang M , Baron M , Heilmann S , Deforet M , Ferretti L , Huang TH , Levesque M , Yanai I , Xavier JB*, White RM*, *co-corresponding authors. Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma. 2020, in revision, available at https://www.biorxiv.org/content/10.1101/2020.08.24.265140v1

Hunter MV+, Moncada R+, Weiss JM, Yanai I*, White RM*,+co-authors, *co-corresponding authors. Spatial transcriptomics reveals the architecture of the tumor/microenvironment interface. 2020, in review, available at https://www.biorxiv.org/content/10.1101/2020.11.05.368753v1

Lumaqin D+, Johns E+, Weiss JM, Montal E, Ooladipupo O, Abuhashem A, White RM. An in vivo reporter for tracking lipid droplet dynamics in transparent zebrafish. +co-authors. 2020, in revision, available at https://www.biorxiv.org/content/10.1101/2020.11.09.375667v1

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People

Dr. Richard White

Richard White, MD, PhD

  • Cancer biologist and oncologist Richard White uses the zebrafish to dissect interactions between tumor cells and the microenvironment that promote metastasis.
  • Albany Medical College: M.D., Ph.D.
  • Yale New Haven Hospital: Internal Medicine Residency & Chief Residency
  • Dana Farber Cancer Institute & Massachusetts General Hospital: Medical Oncology Fellowship
  • Children’s Hospital Boston & Harvard Medical School: Postdoctoral Fellowship
whiter@mskcc.org
Email Address
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Physician profile

Members

Thomas Beckham
Thomas Beckham

Clinical Fellow

Nathaniel Campbell
Nathaniel Campbell

MD–PhD student

Ting-Hsiang (Richard) Huang
Ting-Hsiang (Richard) Huang

Postdoctoral Fellow

Miranda Hunter
Miranda Hunter

Postdoctoral Fellow

Emily B. Johnson, MPH
Emily B. Johnson

Assistant

Dianne Lumaquin
Dianne Lumaquin

MD-PhD student

Theresa Simon-Vermot
Theresa Simon-Vermot

Senior Technician

Shruthy Suresh
Shruthy Suresh

Research Fellow

Mohita Malay Tagore
Mohita Malay Tagore
Antonius Van Boxtel
Antonius Van Boxtel
Joshua Weiss
Joshua Weiss

MD, PhD Student

Lab Alumni
Scott J. Callahan, PhD
Scott J. Callahan

Medical Director at Havas Health & You, New York, NY

Sara Fischer
Sara Fischer

Assistant

Emily Kansler
Emily Kansler

Senior Research Technician

Isabella Kim
Isabella Kim

Research Technician

Liz Perry
Liz Perry

Postdoctoral Fellow

Kajan Ratnakumar
Kajan Ratnakumar

Postdoctoral Fellow

Grant Robinson, BS
Grant Robinson

Graduate Student

Kelsey Temprine, BS
Kelsey R. Temprine

Graduate Student

Maomao (Xiang) Zhang
Maomao (Xiang) Zhang
Yan Zhang
Yan Zhang

Graduate Student

Milena Zimmer
Milena Zimmer
Lab Affilations

Achievements

  • NIH Directors New Innovator Award
  • Young Mentor Award, Melanoma Research Alliance
  • Young Investigator Award, American Association for Cancer Research/American Society of Clinical Oncology
  • Young Mentor Award, Harvard Medical School
  • Outstanding Educator Award, Yale School of Medicine, Department of Internal Medicine

Open Positions

Postdoctoral position: Modeling metastasis in the zebrafish

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Postdoctoral position: Pigmentation in the zebrafish

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Get in Touch

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Richard White discloses the following relationships and financial interests:

  • Consano
    Provision of Services (uncompensated)
  • N-of-One Therapeutics, Inc.
    Provision of Services

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2019 through disclosure submission in spring 2020). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.


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