Zebrafish models of cancer
The zebrafish has emerged as a new model for studying cancer progression and metastasis. We have developed a transparent strain of zebrafish, called casper, that allows for single-cell imaging of how tumor cells interact with cells in the microenvironment. These cell-cell interactions play fundamental roles in shaping tumor cell behavior. Using a zebrafish model of melanoma, we use state of the art genetic engineering and high-resolution imaging to dissect these interactions. Our goal is to understand the mechanisms that allow tumors to successfully disseminate and take hold in new locations, which is the major cause of cancer mortality.
Richard White, MD, PhD
Research FocusCancer biologist and oncologist Richard White uses the zebrafish to dissect interactions between tumor cells and the microenvironment that promote metastasis.
- Albany Medical College: M.D., Ph.D.
- Yale New Haven Hospital: Internal Medicine Residency & Chief Residency
- Dana Farber Cancer Institute & Massachusetts General Hospital: Medical Oncology Fellowship
- Children’s Hospital Boston & Harvard Medical School: Postdoctoral Fellowship
- Baron M, Kim IS, Moncada R, Yan Y, Campbell NR, White RM, Yanai I. Cancer archetypes co-opt and adapt the transcriptional programs of existing cellular states. In review.
- Temprine K, Langdon EM, Mehta K, Clapp A, White RM. Regulation of the error-prone DNA polymerase polκ by oncogenic signaling and its contribution to drug resistance. In review.
- NIH Directors New Innovator Award
- Young Mentor Award, Melanoma Research Alliance
- Young Investigator Award, American Association for Cancer Research/American Society of Clinical Oncology
- Young Mentor Award, Harvard Medical School
- Outstanding Educator Award, Yale School of Medicine, Department of Internal Medicine