Somatic tissue engineering in mouse models reveals an actionable role for WNT pathway alterations in prostate cancer metastasis. Leibold J, Ruscetti M, Cao Z, Ho YJ, Baslan T, Zou M, Abida W, Feucht J, Han T, Barriga FM, Tsanov KM, Zamechek L, Kulick A, Amor C, Tian S, Rybczyk K, Salgado NR, Sanchez-Rivera FJ, Watson PA, de Stanchina E, Wilkinson JE, Dow LE, Abate-Shen C, Sawyers CL, Lowe SW. Cancer Discov. 2020 May 6. pii: CD-19-1242. doi: 10.1158/2159-8290.CD-19-1242. [Epub ahead of print] PMID: 32376773

Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer. Ruscetti M, Morris JP 4th, Mezzadra R, Russell J, Leibold J, Romesser PB, Simon J, Kulick A, Ho YJ, Fennell M, Li J, Norgard RJ, Wilkinson JE, Alonso-Curbelo D, Sridharan R, Heller DA, de Stanchina E, Stanger BZ, Sherr CJ, Lowe SW. Cell. 2020 Apr 16;181(2):424-441.e21. doi: 10.1016/j.cell.2020.03.008. Epub 2020 Mar 31. PMID:32234521

Vitamin B6 Addiction in Acute Myeloid Leukemia. Chen CC, Li B, Millman SE, Chen C, Li X, Morris JP 4th, Mayle A, Ho YJ, Loizou E, Liu H, Qin W, Shah H, Violante S, Cross JR, Lowe SW, Zhang L. Cancer Cell. 2020 Jan 13;37(1):71-84.e7. doi: 10.1016/j.ccell.2019.12.002. PMID: 31935373

Preclinical murine platform to evaluate therapeutic countermeasures against radiation-induced gastrointestinal syndrome. Romesser PB, Kim AS, Jeong J, Mayle A, Dow LE, Lowe SW. Proc Natl Acad Sci U S A. 2019 Sep 24. pii: 201906611. doi: 10.1073/pnas.1906611116. PMID: 31551264

α-Ketoglutarate links p53 to cell fate during tumour suppression. Morris JP 4th, Yashinskie JJ, Koche R, Chandwani R, Tian S, Chen CC, Baslan T, Marinkovic ZS, Sánchez-Rivera FJ, Leach SD, Carmona-Fontaine C, Thompson CB, Finley LWS, Lowe SW. Nature. 2019 Sep 18. doi: 10.1038/s41586-019-1577-5. PMID: 31534224

A gain-of-function p53 mutant oncogene promotes cell fate plasticity and myeloidleukemia through the pluripotency factor Foxh1. Loizou E, Banito A, Livshits G, Ho YJ, Koche RP, Sanchez-Rivera FJ, Mayle A, Chen CC, Kinalis S, Bagger FO, Kastenhuber ER, Durham BH, Lowe SW. Cancer Discov. 2019 May 8. pii: CD-18-1391. doi: 10.1158/2159-8290.CD-18-1391. PMID: 31068365

NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination. Ruscetti M, Leibold J, Bott MJ, Fennell M, Kulick A, Salgado NR, Chen CC, Ho YJ, Sanchez-Rivera FJ, Feucht J, Baslan T, Tian S, Chen HA, Romesser PB, Poirier JT, Rudin CM, de Stanchina E, Manchado E, Sherr CJ, Lowe SW. Science. 2018 Dec 21;362(6421):1416-1422. doi: 10.1126/science.aas9090. PMID: 30573629

The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma. Banito A, Li X, Laporte AN, Roe JS, Sanchez-Vega F, Huang CH, Dancsok AR, Hatzi K, Chen CC, Tschaharganeh DF, Chandwani R, Tasdemir N, Jones KB, Capecchi MR, Vakoc CR, Schultz N, Ladanyi M, Nielsen TO, Lowe SW. Cancer Cell. 2018 Mar 12;33(3):527-541.e8. doi: 10.1016/j.ccell.2018.01.018. Epub 2018 Mar 1. PMID: 29502955

DNAJB1-PRKACA fusion kinase interacts with β-catenin and the liver regenerative response to drive fibrolamellar hepatocellular carcinoma. Kastenhuber ER, Lalazar G, Houlihan SL, Tschaharganeh DF, Baslan T, Chen CC, Requena D, Tian S, Bosbach B, Wilkinson JE, Simon SM, Lowe SW. Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):13076-13084. doi: 10.1073/pnas.1716483114. Epub 2017 Nov 21. PMID:29162699

Putting p53 in Context. Kastenhuber ER, Lowe SW. Cell. 2017 Sep 7;170(6):1062-1078. doi: 10.1016/j.cell.2017.08.028. Review. PMID:28886379

Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer. O’Rourke KP, Loizou E, Livshits G, Schatoff EM, Baslan T, Manchado E, Simon J, Romesser PB, Leach B, Han T, Pauli C, Beltran H, Rubin MA, Dow LE, Lowe SW. Nat Biotechnol. 2017 Jun;35(6):577-582. doi: 10.1038/nbt.3837. Epub 2017 May 1. PMID: 28459450

A pipeline for drug target identification and validation. Manchado E, Huang CH, Tasdemir N, Tschaharganeh DF, Wilkinson JE, Lowe SW. Cold Spring Harb Symp Quant Biol. 2016;81:257-267. doi: 10.1101/sqb.2016.81.031096. Epub 2017 Jan 5. PMID: 28057848

A combinatorial strategy for treating KRAS-mutant lung cancer. Manchado E, Weissmueller S, Morris JP 4th, Chen CC, Wullenkord R, Lujambio A, de Stanchina E, Poirier JT, Gainor JF, Corcoran RB, Engelman JA, Rudin CM, Rosen N, Lowe SW. Nature. 2016 Jun 30;534(7609):647-51. Epub 2016 Jun 22. PMID: 27338794

BRD4 connects enhancer remodeling to senescence immune surveillance. Tasdemir N, Banito A, Roe JS, Alonso-Curbelo D, Camiolo M, Tschaharganeh DF, Huang CH, Aksoy O, Bolden JE, Chen CC, Fennell M, Thapar V, Chicas A, Vakoc CR, Lowe SW. Cancer Discov. 2016 Jun;6(6):612-29. doi: 10.1158/2159-8290.CD-16-0217. Epub 2016 Apr 20. PMID: 27099234

Deletions linked to TP53 loss drive cancer through p53-independent mechanisms. Liu Y, Chen C, Xu Z, Scuoppo C, Rillahan CD, Gao J, Spitzer B, Bosbach B, Kastenhuber ER, Baslan T, Ackermann S, Cheng L, Wang Q, Niu T, Schultz N, Levine RL, Mills AA, Lowe SW. Nature. 2016 Mar 24;531(7595):471-475. doi: 10.1038/nature17157. Epub 2016 Mar 16. PMID: 26982726

Pten loss promotes MAPK pathway dependency in HER2/neu breast carcinomas. Ebbesen SH, Scaltriti M, Bialucha CU, Morse N, Kastenhuber ER, Wen HY, Dow LE, Baselga J, Lowe SW. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3030-5. doi: 10.1073/pnas.1523693113. Epub 2016 Feb 29. PMID: 26929372

Apc restoration promotes cellular differentiation and reestablishes crypt homeostasis in colorectal cancer. Dow LE, O’Rourke KP, Simon J, Tschaharganeh DF, van Es JH, Clevers H, Lowe SW. Cell. 2015 Jun 18;161(7):1539-1552. doi: 10.1016/j.cell.2015.05.033. PMID: 26091037

Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis. Zhao Z, Chen CC, Rillahan CD, Shen R, Kitzing T, McNerney ME, Diaz-Flores E, Zuber J, Shannon K, Le Beau MM, Spector MS, Kogan SC, Lowe SW. Nat Genet. 2015 May;47(5):539-43. doi: 10.1038/ng.3251. Epub 2015 Mar 30. PMID: 25822087

Inducible in vivo genome editing with CRISPR-Cas9. Dow LE, Fisher J, O’Rourke KP, Muley A, Kastenhuber ER, Livshits G, Tschaharganeh DF, Socci ND, Lowe SW. Nat Biotechnol. 2015 Apr;33(4):390-394. doi: 10.1038/nbt.3155. Epub 2015 Feb 18. PMID: 25690852

p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer. Tschaharganeh DF, Xue W, Calvisi DF, Evert M, Michurina TV, Dow LE, Banito A, Katz SF, Kastenhuber ER, Weissmueller S, Huang CH, Lechel A, Andersen JB, Capper D, Zender L, Longerich T, Enikolopov G, Lowe SW. Cell. 2014 Jul 31;158(3):579-92. doi: 10.1016/j.cell.2014.05.051. PMID:25083869

PTEN action in leukaemia dictated by the tissue microenvironment. Miething C, Scuoppo C, Bosbach B, Appelmann I, Nakitandwe J, Ma J, Wu G, Lintault L, Auer M, Premsrirut PK, Teruya-Feldstein J, Hicks J, Benveniste H, Speicher MR, Downing JR, Lowe SW. Nature. 2014 Jun 19;510(7505):402-6. doi: 10.1038/nature13239. Epub 2014 May 4. PMID: 24805236

Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor β signaling. Weissmueller S, Manchado E, Saborowski M, Morris JP 4th, Wagenblast E, Davis CA, Moon SH, Pfister NT, Tschaharganeh DF, Kitzing T, Aust D, Markert EK, Wu J, Grimmond SM, Pilarsky C, Prives C, Biankin AV, Lowe SW. Cell. 2014 Apr 10;157(2):382-394. doi: 10.1016/j.cell.2014.01.066. PMID: 24725405