Cancer Biology & Genetics Program

The Scott Lowe Lab

Scott W. Lowe, PhD

Chair, Cancer Biology & Genetics Program, SKI; Chair, Geoffrey Beene Cancer Research Center; Investigator, Howard Hughes Medical Institute

About the Scott Lowe Lab

Our laboratory studies tumor-suppressor networks controlling apoptosis and senescence and how their disruption influences malignant behavior.

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Research Projects

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Featured News

Sloan Kettering Institute Scientists Learn How Genes and Environment Conspire in Pancreatic Cancer Development

Wednesday, February 3, 2021

The insights lay the groundwork for earlier diagnosis and better treatment of the disease.

Confronting a Crisis: How MSK Cancer Geneticists Responded to COVID-19

Friday, January 8, 2021

During World War II, US factories famously converted their operations to support the war effort. COVID-19 instigated something similar among cancer scientists.

In the Lab

Fluorescent image of CAR T cells in mouse liver fibrosis

A New Target for CAR T Cells: Senescence-Related Diseases

Wednesday, June 17, 2020

From atherosclerosis and diabetes to liver fibrosis and osteoarthritis, senescent cells are at the root of many debilitating diseases. Scientists increasingly have them in the crosshairs.

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Publications

A gene–environment-induced epigenetic program initiates tumorigenesis. Alonso-Curbelo, D, Ho, YJ, Burdziak, C, Maag, JLV, Morris IV, JP, Chandwani, R, Chen, HA, Tsanov, KM, Barriga, FM, Luan, W, Tasdemir, N, Livshits, G, Azizi, E, Chun, J, Wilkinson, JE, Mazutis, L, Leach, SD, Koche, R, Pe’er, D, Lowe, SW. Nature. 2021 Feb;590(7847):642-648. PMID: 33536616.

Senolytic CAR T Cells Reverse Senescence-Associated Pathologies. Amor, C, Feucht, J, Leibold, J, Ho, YJ, Zhu, C, Alonso-Curbelo, D, Mansilla-Soto, J, Boyer, JA, Li, X, Giavridis, T, Kulick, A, Houlihan, S, Peerschke, E, Friedman, SL, Ponomarev, V, Piersigilli, A, Sadelain, M, Lowe, SW. Nature. 2020 Jul;583(7814):127-132. PMID: 32555459.

Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer. Ruscetti, M, Morris IV, JP, Mezzadra, R, Russell, J, Leibold, J, Romesser, PB, Simon, J, Kulick, A, Ho, YJ, Fennell, M, Li, J, Norgard, RJ, Wilkinson, JE, Alonso-Curbelo, D, Sridharan, R, Heller, DA, de Stanchina, E, Stanger, BZ, Sherr, CJ, Lowe, SW. Cell. 2020 Apr 16;181(2):424-441.e21. PMID: 32234521.

α-Ketoglutarate links p53 to cell fate during tumor suppression. Morris IV, JP, Yashinskie, JJ, Koche, R, Chandwani, R, Tian, S, Chen, C-C, Baslan, T, Marinkovic, ZS, Sanchez-Rivera, FJ, Leach, SD, Carmona-Fontaine, C, Thompson, CB, Finley, LWS, Lowe, SW. Nature. 2019 Sep;573(7775):595-599. PMID: 31534224.

NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination. Ruscetti, M, Leibold, J, Bott, MJ, Fennell, M, Kulick, A, Chen, C-C, Baslan, T, Salgado, NR, Sanchez-Rivera, FJ, Tian, S, Romesser PB, Poirier, JT, Rudin, CM, de Stanchina, E, Manchado, E, Sherr, CJ, and Lowe, SW. Science. 2018 Dec 21;362(6421):1416-1422. PMID: 30573629.

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People

Scott W. Lowe, PhD

Chair, Cancer Biology & Genetics Program, SKI; Chair, Geoffrey Beene Cancer Research Center; Investigator, Howard Hughes Medical Institute

Cancer biologist Scott Lowe uses genetically engineered mouse models to study how the genetic alterations in cancer cells contribute to tumorigenesis, alter treatment response, and create molecular vulnerabilities that may be targeted therapeutically.
PhD, Massachusetts Institute of Technology

[email protected]: Email Address
646-888-3342: Office Phone
Download CV: PDF File

Members

Francisco Barriga, PhD — Francisco (Pancho) Barriga
Postdoctoral Researcher

Valentin Barthet
Postdoctoral Researcher

Andrea Chaikovsky
Postdoctoral Researcher

Almudena Chaves Perez
Postdoctoral Researcher

Isabella Del Priore, BS — Isabella Del Priore
Graduate Student

Clemens Hinterleitner
Postdoctoral Researcher

Yu-Jui (Ray) Ho, PhD — Yu-Jui (Ray) Ho
Computational Biologist

Domhnall McHugh, PhD — Domhnall McHugh
Postdoctoral Researcher

Riccardo Mezzadra
Postdoctoral Researcher

Kaloyan Tsanov, PhD — Kaloyan Tsanov
Postdoctoral Researcher

Janelle Simon, BS — Janelle Simon
Mouse Colony Manager

Wei Luan, MD — Wei Luan
Senior Research Technician

Sha Tian, MS — Sha Tian
Senior Research Technician

Lynn Boss, MS — Lynn Boss
Administrative Coordinator

Lab Alumni

Direna Alonso Curbelo, PhD — Direna Alonso Curbelo
Junior Group Leader, Cancer Science, IRB Barcelona, Spain

Iris Appelmann, MD — Iris Appelmann
Physician, University Hospital RWTH Aachen, Germany

Corina Amor Vegas
CSHL Independent Fellow at Cold Spring Harbor Laboratory, Cold Spring Harbor, NY

Ana Banito, PhD — Ana Banito
Group Leader, German Cancer Research Center (DKFZ), Heidelberg, Germany

Benedikt Bosbach, PhD — Benedikt Bosbach
Principal Scientist, CTI, Pfizer Research, New York

Chi-Chao Chen, MD — Chi-Chao Chen
Data Scientist, Agios Pharmaceuticals, Inc., Cambridge, MA

Hsuan-An Chen — Hsuan-An (Sean) Chen
Postdoctoral Associate at Rockefeller University, New York, NY

Chong Chen, PhD — Chong Chen
Professor, Sichuan University, Sichuan, China

Lukas Dow, PhD — Lukas Dow
Assistant Professor, Weill Cornell Medical College, New York, NY

Saya Ebbesen, PhD — Saya Ebbesen
Director, Medical & Scientific Strategy, BluPrint Oncology, London

Katerina Hatzi, PhD — Katerina Hatzi
Senior Scientist, Oncology Biomarker Development, Genentech, San Francisco, CA

Shauna Houlihan, PhD — Shauna Houlihan
Associate Director, Liver Research, Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY

Grace Xiang Li, MS — Xiang (Grace) Li
Postdoctoral Fellow, Harvard University, Cambridge, MA

Chun-Hao Huang, PhD — Chun-Hao Huang
Co-Founder & CEO, Algen Biotechnologies, San Francisco, CA

Edward Kastenhuber, PhD — Edward (Ted) Kastenhuber
Postdoctoral Associate, Weill Cornell Medicine, New York, NY

Thomas Kitzing, PhD — Thomas Kitzing
Senior Research Scientist, Philipps University of Marburg, Institute of Pharmacology, Germany

Josef Leibold, MD — Josef Leibold
Group Leader, University of Tübingen, Germany

Kiki Yu Liu, PhD — Yu (Kiki) Liu
Professor, Sichuan University, Sichuan, China

Geulah Livshits, PhD — Geulah Livshits
Senior Research Analyst, Biotechnology and Pharmaceuticals, Chardan Capital Markets LLC, New York, NY

Bryan Ngo
Group Leader, Altos Labs, San Francisco, CA

Stella Paffenholz, PhD — Stella Paffenholz
Venture Capital Associate, Nextech Invest, Boston, MA

Francisco Sánchez-Rivera, PhD — Francisco J. Sánchez-Rivera
Assistant Professor of Biology, Massachusetts Institute of Technology, Cambridge, MA

Evangelia Loizou, PhD — Evangelia Loizou
Senior Research Associate, Intelligencia, New York, NY

Amaia Lujambio, PhD — Amaia Lujambio
Associate Professor, Mount Sinai School of Medicine, New York, NY

Eusebio Manchado Robles, PhD — Eusebio Manchado Robles
Senior Principal Scientist, Novartis, Basel, Switzerland

Allison Mayle, Postdoctoral Researcher — Allison Mayle
Assistant Director, DNALC, Cold Spring Harbor Laboratory, New York

Ozlem Mert, PhD — Özlem Aksoy (née Mert)
Senior Scientist, Pfizer, San Francisco, CA

Cornelius Miething, PhD — Cornelius Miething
Group Leader and Medical Fellow, University Medical Center Freiburg, Germany

John P. Morris IV, PhD — John P. Morris IV
Assistant Professor, Department of Pharmacology, University of North Carolina, Chapel Hill, NC

Kevin P. O'Rourke

Investments, Roivant Sciences, New York, NY

Cory Rillahan, MD, PhD — Cory Rillahan
Clinical Fellow, Pediatrics, Boston Children's Hospital, Boston, MA

Marcus Ruscetti, PhD — Marcus Ruscetti
Assistant Professor, Molecular, Cell & Cancer Biology, University of Massachusetts Medical School, Worcester, MA

Anna Saborowski, MD — Anna Saborowski
Physician, Hannover Medical School, Germany

Michael Saborowski, MD — Michael Saborowski
Physician, Hannover Medical School, Germany

Charles J Sherr — Charles J. Sherr
Chair, Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN

Nilgun Tasdemir, PhD — Nilgun Tasdemir
Senior Scientist, Functional Genomics, Target Sciences, Pfizer, New York, NY

Darjus Tschaharganeh, MD — Darjus Tschaharganeh
Group Leader, German Cancer Research Center (DKFZ), Heidelberg, Germany

Susann Weissmueller, PhD — Susann Weissmueller
Strategic Partnering Associate, Roche, Basel, Switzerland

Zhen Zhao, MD PhD — Zhen Zhao
Pathology Resident, The Mount Sinai Hospital, New York, NY

Sarah Ackermann
Research Specialist, Weill Cornell Medicine, New York, NY

James H. Ahn, MS — James H. Ahn
Research Technician

Erica Anderson, BS — Erica Anderson
Research Technician

Ho-Chung Chen, MS — Ho-Chung Chen
Research Technician

Jonathan Fisher, BS — Jonathan Fisher
Research Technician

Danielle Grace, BS — Danielle Grace
Research Technician

Fernanda Luna, BA — Fernanda Luna
Research Technician

Jamie Plevy, BSE MS — Jamie Plevy
Research Technician

Katarzyna Rybczyk — Katarzyna (Kasia) Rybczyk
Research Technician

Aditya S. Shroff, BS — Aditya S. Shroff
Research Technician

Meredith Taylor, BS — Meredith Taylor
Research Technician

Leah Zamechek, MS — Leah Zamechek
Laboratory Manager

Lab Affiliations

Lab News & Events

Tweets by @https://twitter.com/LoweLabMSKCC

Upcoming event

Mapping Genotypes to Phenotypes in Clonal Hematopoiesis and Hematological Malignancies through Single Cell Resolution Multi-Modal Approaches

Monday, February 6, 2023 - 12:00 PM to 1:00 PM

Memorial Sloan Kettering Cancer Center
Zuckerman Research Center
417 East 68th Street
Room ZRC-105
New York, NY 10065

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

Postdoctoral Fellow – Leukemia Group

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Research Technician

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Get in Touch

[email protected]

Lab Head Email
646-888-3342

Office Phone
646-888-3347

Office Fax
646-888-3340

Lab Phone
Lowe Lab Twitter

Lab Resources

Scott Lowe Lab Plasmid and Animal Requests

Request plasmids through Addgene More »

For plasmids not listed on Addgene, please contact our Lab Manager, Anne Trumble-Koncelik, [email protected].

For animal requests, please contact our Mouse Colony Manager, Janelle Simon, [email protected].

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Scott W. Lowe discloses the following relationships and financial interests:

Algen
Intellectual Property Rights
Blueprint Medicines
Ownership / Equity Interests; Provision of Services
Constellation Pharmaceuticals
Ownership / Equity Interests; Provision of Services
Eli Lilly and Company
Provision of Services
Faeth Therapeutics, Inc
Ownership / Equity Interests; Provision of Services (uncompensated)

Geras Bio Inc
Ownership / Equity Interests; Provision of Services (uncompensated)
Mirimus
Ownership / Equity Interests; Provision of Services
Oric Pharmaceuticals
Ownership / Equity Interests; Provision of Services
PMV Pharma
Ownership / Equity Interests; Provision of Services
Petra Pharma Corporation
Ownership / Equity Interests; Provision of Services

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2021 through disclosure submission in spring 2022). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].

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