A gene–environment-induced epigenetic program initiates tumorigenesis. Alonso-Curbelo, D, Ho, YJ, Burdziak, C, Maag, JLV, Morris IV, JP, Chandwani, R, Chen, HA, Tsanov, KM, Barriga, FM, Luan, W, Tasdemir, N, Livshits, G, Azizi, E, Chun, J, Wilkinson, JE, Mazutis, L, Leach, SD, Koche, R, Pe’er, D, Lowe, SW. Nature. 2021 Feb;590(7847):642-648. PMID: 33536616.

Senolytic CAR T Cells Reverse Senescence-Associated Pathologies. Amor, C, Feucht, J, Leibold, J, Ho, YJ, Zhu, C, Alonso-Curbelo, D, Mansilla-Soto, J, Boyer, JA, Li, X, Giavridis, T, Kulick, A, Houlihan, S, Peerschke, E, Friedman, SL, Ponomarev, V, Piersigilli, A, Sadelain, M, Lowe, SW. Nature. 2020 Jul;583(7814):127-132. PMID: 32555459.

Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer. Ruscetti, M, Morris IV, JP, Mezzadra, R, Russell, J, Leibold, J, Romesser, PB, Simon, J, Kulick, A, Ho, YJ, Fennell, M, Li, J, Norgard, RJ, Wilkinson, JE, Alonso-Curbelo, D, Sridharan, R, Heller, DA, de Stanchina, E, Stanger, BZ, Sherr, CJ, Lowe, SW. Cell. 2020 Apr 16;181(2):424-441.e21. PMID: 32234521.

α-Ketoglutarate links p53 to cell fate during tumor suppression. Morris IV, JP, Yashinskie, JJ, Koche, R, Chandwani, R, Tian, S, Chen, C-C, Baslan, T, Marinkovic, ZS, Sanchez-Rivera, FJ, Leach, SD, Carmona-Fontaine, C, Thompson, CB, Finley, LWS, Lowe, SW. Nature. 2019 Sep;573(7775):595-599. PMID: 31534224.

NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination. Ruscetti, M, Leibold, J, Bott, MJ, Fennell, M, Kulick, A, Chen, C-C, Baslan, T, Salgado, NR, Sanchez-Rivera, FJ, Tian, S, Romesser PB, Poirier, JT, Rudin, CM, de Stanchina, E, Manchado, E, Sherr, CJ, and Lowe, SW. Science. 2018 Dec 21;362(6421):1416-1422. PMID: 30573629.

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People

Scott W. Lowe, PhD

Chair, Cancer Biology & Genetics Program, SKI; Chair, Geoffrey Beene Cancer Research Center; Investigator, Howard Hughes Medical Institute

Cancer biologist Scott Lowe uses genetically engineered mouse models to study how the genetic alterations in cancer cells contribute to tumorigenesis, alter treatment response, and create molecular vulnerabilities that may be targeted therapeutically.
PhD, Massachusetts Institute of Technology

lowes@mskcc.org: Email Address
646-888-3342: Office Phone
Download CV: PDF File

Members

Direna Alonso Curbelo, PhD — Direna Alonso Curbelo
Postdoctoral Researcher

Francisco Barriga, PhD — Francisco (Pancho) Barriga
Postdoctoral Researcher

Almudena Chaves Perez
Postdoctoral Researcher

Hsuan-An Chen — Hsuan-An (Sean) Chen
Graduate Student

Yu-Jui (Ray) Ho, PhD — Yu-Jui (Ray) Ho
Computational Biologist

Grace Xiang Li, MS — Xiang (Grace) Li
Graduate Student

Riccardo Mezzadra
Postdoctoral Researcher

S Millman, MD PhD — Scott Millman
Instructor in Medicine

Stella Paffenholz, MS — Stella Paffenholz
Graduate Student

Francisco Sánchez-Rivera, PhD — Francisco Sánchez-Rivera
Postdoctoral Researcher

Kaloyan Tsanov, PhD — Kaloyan Tsanov
Postdoctoral Researcher

Janelle Simon, BS — Janelle Simon
Mouse Colony Manager

Wei Luan, MD — Wei Luan
Senior Research Technician

Sha Tian, MS — Sha Tian
Senior Research Technician

Lynn Boss, MS — Lynn Boss
Administrative Coordinator

Lab Alumni

Iris Appelmann, MD — Iris Appelmann
Physician, University Hospital RWTH Aachen, Germany

Ana Banito, PhD — Ana Banito
Group Leader, German Cancer Research Center (DKFZ), Heidelberg, Germany

Benedikt Bosbach, PhD — Benedikt Bosbach
Principal Scientist, CTI, Pfizer Research, New York

Chi-Chao Chen, MD — Chi-Chao Chen
Data Scientist, Agios Pharmaceuticals, Inc., Cambridge, MA

Chong Chen, PhD — Chong Chen
Professor, Sichuan University, Sichuan, China

Lukas Dow, PhD — Lukas Dow
Assistant Professor, Weill Cornell Medical College, New York, NY

Saya Ebbesen, PhD — Saya Ebbesen
Director, Medical & Scientific Strategy, BluPrint Oncology, London

Katerina Hatzi, PhD — Katerina Hatzi
Senior Scientist, Oncology Biomarker Development, Genentech, San Francisco, CA

Shauna Houlihan, PhD — Shauna Houlihan
Associate Director, Liver Research, Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY

Chun-Hao Huang, PhD — Chun-Hao Huang
Co-Founder & CEO, Algen Biotechnologies, San Francisco, CA

Edward Kastenhuber, PhD — Edward (Ted) Kastenhuber
Postdoctoral Associate at Weill Cornell Medicine, New York, NY

Thomas Kitzing, PhD — Thomas Kitzing
Senior Research Scientist, Philipps University of Marburg, Institute of Pharmacology, Germany

Josef Leibold, MD — Josef Leibold
Group Leader, University of Tübingen, Germany

Kiki Yu Liu, PhD — Yu (Kiki) Liu
Professor, Sichuan University, Sichuan, China

Geulah Livshits, PhD — Geulah Livshits
Senior Research Analyst, Biotechnology and Pharmaceuticals, Chardan Capital Markets LLC, New York, NY

Evangelia Loizou, PhD — Evangelia Loizou
Product Development Manager, NIPD Genetics, New York, NY

Amaia Lujambio, PhD — Amaia Lujambio
Associate Professor, Mount Sinai School of Medicine, New York, NY

Eusebio Manchado Robles, PhD — Eusebio Manchado Robles
Senior Principal Scientist, Novartis, Basel, Switzerland

Allison Mayle, Postdoctoral Researcher — Allison Mayle
Assistant Director, DNALC, Cold Spring Harbor Laboratory, New York

Ozlem Mert, PhD — Özlem Aksoy (née Mert)
Senior Scientist, Pfizer, San Francisco, CA

Cornelius Miething, PhD — Cornelius Miething
Group Leader and Medical Fellow, University Medical Center Freiburg, Germany

John P. Morris IV, PhD — John P. Morris IV
Assistant Professor, Department of Pharmacology, University of North Carolina, Chapel Hill, NC

Kevin P. O'Rourke

Investments, Roivant Sciences, New York, NY

Cory Rillahan, MD, PhD — Cory Rillahan
Clinical Fellow, Pediatrics, Boston Children's Hospital, Boston, MA

Marcus Ruscetti, PhD — Marcus Ruscetti
Assistant Professor, Molecular, Cell & Cancer Biology, University of Massachusetts Medical School, Worcester, MA

Anna Saborowski, MD — Anna Saborowski
Physician, Hannover Medical School, Germany

Michael Saborowski, MD — Michael Saborowski
Physician, Hannover Medical School, Germany

Charles J Sherr — Charles J. Sherr
Chair, Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN

Nilgun Tasdemir, PhD — Nilgun Tasdemir
Senior Scientist, Functional Genomics, Target Sciences, Pfizer, New York, NY

Darjus Tschaharganeh, MD — Darjus Tschaharganeh
Group Leader, German Cancer Research Center (DKFZ), Heidelberg, Germany

Susann Weissmueller, PhD — Susann Weissmueller
Strategic Partnering Associate, Roche, Basel, Switzerland

Zhen Zhao, MD PhD — Zhen Zhao
Pathology Resident, The Mount Sinai Hospital, New York, NY

Sarah Ackermann
Research Specialist, Weill Cornell Medicine, New York, NY

James H. Ahn, MS — James H. Ahn
Research Technician

Erica Anderson, BS — Erica Anderson
Research Technician

Ho-Chung Chen, MS — Ho-Chung Chen
Research Technician

Jonathan Fisher, BS — Jonathan Fisher
Research Technician

Danielle Grace, BS — Danielle Grace
Research Technician

Fernanda Luna, BA — Fernanda Luna
Research Technician

Jamie Plevy, BSE MS — Jamie Plevy
Research Technician

Katarzyna Rybczyk — Katarzyna (Kasia) Rybczyk
Research Technician

Aditya S. Shroff, BS — Aditya S. Shroff
Research Technician

Meredith Taylor, BS — Meredith Taylor
Research Technician

Leah Zamechek, MS — Leah Zamechek
Laboratory Manager

Lab Affiliations

Lab News & Events

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Upcoming event

Interrogating the Cancer Genome at Base Pair Resolution

Monday, November 15, 2021 - 5PM

This seminar will be held by Zoom webinar.

Open Positions

Postdoctoral Fellow – Leukemia Group

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Research Technician

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Get in Touch

lowes@mskcc.org

Lab Head Email
646-888-3342

Office Phone
646-888-3347

Office Fax
646-888-3340

Lab Phone
Lowe Lab Twitter

Lab Resources

Scott Lowe Lab Plasmid and Animal Requests

Request plasmids through Addgene More »

For plasmids not listed on Addgene, please contact our Lab Manager, Anne Trumble-Koncelik, trumblea@mskcc.org.

For animal requests, please contact our Mouse Colony Manager, Janelle Simon, simonj@mskcc.org.

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Scott W. Lowe discloses the following relationships and financial interests:

Algen
Intellectual Property Rights
Blueprint Medicines
Ownership / Equity Interests; Provision of Services
Constellation Pharmaceuticals
Ownership / Equity Interests; Provision of Services
Eli Lilly and Company
Provision of Services
Faeth Therapeutics, Inc
Ownership / Equity Interests; Provision of Services (uncompensated)

Geras Bio Inc
Ownership / Equity Interests; Provision of Services (uncompensated)
Mirimus
Ownership / Equity Interests; Provision of Services
Oric Pharmaceuticals
Ownership / Equity Interests; Provision of Services
PMV Pharma
Ownership / Equity Interests; Provision of Services
Petra Pharma Corporation
Ownership / Equity Interests; Provision of Services

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2020 through disclosure submission in spring 2021). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.

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