Inside My Lab: Scott Lowe
About the Scott Lowe Lab
Our laboratory studies tumor-suppressor networks controlling apoptosis and senescence and how their disruption influences malignant behavior.
Request plasmids through addgene More »
For plasmids not listed on addgene, please contact the lab manager, Anne Trumble-Koncelik, trumblea@mskcc.org.
For animal requests, please contact the mouse colony manager, Janelle Simon, simonj@mskcc.org.
Scott W. Lowe, PhD
Chair, Cancer Biology & Genetics Program, SKI; Chair, Geoffrey Beene Cancer Research Center
Professor
Research Focus
Cancer biologist Scott Lowe uses genetically engineered mouse models to study how the genetic alterations in cancer cells contribute to tumorigenesis, alter treatment response, and create molecular vulnerabilities that may be targeted therapeutically.Education
PhD, Massachusetts Institute of Technology- Office Phone: 646-888-3342
- Office Fax: 646-888-3347
- Lab Phone 646-888-3340
- Lab Phone 646-888-3345
- Lab Fax: 646-888-3347
Lab Members
Graduate Student
Postdoctoral Researcher
Postdoctoral Researcher
Graduate Student
Computational Biologist
Postdoctoral Researcher
Graduate Student
Postdoctoral Researcher
Postdoctoral Researcher
Instructor in Medicine
Graduate Student
Postdoctoral Researcher
Postdoctoral Researcher
Postdoctoral Researcher
Postdoctoral Researcher
Postdoctoral Researcher
Visiting Investigator/Advisor
Administrative Coordinator
Administrative Coordinator
Mouse Colony Manager
Lab Manager
Senior Research Technician
Research Technician
Research Technician
Senior Research Technician
Research Technician
- Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer. Ruscetti M, Morris JP 4th, Mezzadra R, Russell J, Leibold J, Romesser PB, Simon J, Kulick A, Ho YJ, Fennell M, Li J, Norgard RJ, Wilkinson JE, Alonso-Curbelo D, Sridharan R, Heller DA, de Stanchina E, Stanger BZ, Sherr CJ, Lowe SW. Cell. 2020 Apr 16;181(2):424-441.e21. doi: 10.1016/j.cell.2020.03.008. Epub 2020 Mar 31.
- α-Ketoglutarate links p53 to cell fate during tumour suppression. Morris JP 4th, Yashinskie JJ, Koche R, Chandwani R, Tian S, Chen CC, Baslan T, Marinkovic ZS, Sánchez-Rivera FJ, Leach SD, Carmona-Fontaine C, Thompson CB, Finley LWS, Lowe SW. Nature. 2019 Sep 18. doi: 10.1038/s41586-019-1577-5. PMID: 31534224
