Alexander Bolaender, PhD

Research Scholar

Pictured: Alexander Bolaendar

I received my PhD in organic chemistry from the University of Technology Darmstadt (Germany) in 2012. During my PhD thesis I focused on synthesizing new fluorescent ligands to selectively label the notorious protein deposits linked to Alzheimer’s disease in human brain tissue putting particular focus on tau pathology imaging in order to develop new diagnostic approaches for this disease, which is still very limited to date. Efforts thus far have resulted in the discovery of certain areas of the olfactory epithelium and the retina which harbor tau deposits as well. Since the severity of tau load in these regions correlates with the progress of the disease, these results hold potential to detect these deposits endoscopically and, therefore, noninvasively at very high resolution in the living patient.

During the experimental validation of these probes, I gained experience in histochemistry, toxicological evaluation and target affinity determination in vitro and in vivo. At Memorial Sloan Kettering Cancer Center my research in the Chiosis laboratory is focused on the development of small molecule inhibitors of HSP90 and to gain new insight into the role of this protein in the emergence of neurodegenerative diseases. I expect to expand my knowledge on neurodegenerative diseases and to acquire deep insights into the mechanisms of carcinogenesis and new concepts of cancer therapy based on HSP90 inhibition by the use of small molecules.


Selected Publications and Patent Applications

Alexander Bolaender., Daniel Kieser, Christoph Scholz, Roland Heyny-von Haußen , Gerhard Mall, Valerie Goetschy, Christian Czech, Boris Schmidt, “Synthesis of Methoxy-X04 Derivatives and their Evaluation in Alzheimer’s Disease Pathology”, Neurodegenerative Diseases 2013, DOI:10.1159/000351436.

Alexander Bolaender, Daniel Kieser, Constantin Voss, Silvia Bauer, Christian Schön, Steffen Burgold, Tobias Bittner, Jana Hölzer, Roland Heyny-von Haußen, Gerhard Mall, Valérie Goetschy, Christian Czech, Henner Knust, Robert Berger, Jochen Herms, Ingrid Hilger und Boris Schmidt, “Bis(arylvinyl)pyrazines, -pyrimidines and -pyridazines as imaging agents for tau fibrils and β-Amyloid plaques in Alzheimer’s disease models“, Journal of Medicinal Chemistry 2012, 55, 9170-9180.

Fabio LoMonte, Thomas Kramer, Alexander Bolaender, Batya Plotkin, Hagit Eldar-Finkelman, Ana Fuertes, Juan Dominguez und Boris Schmidt, “Synthesis and biological evaluation of glycogen synthase kinase 3 (GSK-3) inhibitors: A fast and atom efficient access to 1-aryl-3-benzylureas”, Bioorganic & Medicinal Chemistry Letters 2011, 21, 5610-5615.

Methods and devices for the detection of tau protein deposits in eyes, by: Kempe, Michael; Schmitt-Manderbach, Tobias; Herms, Jochen; Schoen, Christian; Schmidt, Boris; Kieser, Daniel; Bolaender, Alexander, Int. Appl. (2013), WO 2013041522 A1 20130328

Heterocyclic compounds for the diagnostics of neurodegenerative illnesses at the olfactory epithelial tissue and their preparation, by: Schmidt, Boris; Kieser, Daniel; Bolaender, Alexander; Herms, Jochen; Heyny-Von Haussen, Roland Hans, Int. Appl. (2012), WO 2012037928 A2 20120329

Fluorescent ligands for protein aggregates and their use in the diagnosis of neurodegenerative diseases at the retina, by Schmidt, Boris; Kieser, Daniel; Bolaender, Alexander; Herms, Jochen; Heyny-Von Haussen, Roland Hans, Int. Appl. (2012), WO 2012041292 A2 20120405.