Postdoctoral fellow/scholar position is available immediately in a multidisciplinary team studying maladaptive changes in proteome-wide protein-protein interaction networks in disease. These efforts will be conducted in collaboration with scientists and clinicians at Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York University Grossman School of Medicine and Columbia University, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain.
For publications relevant to this research please refer to:
- Nature Communications 2020 Jan 16;11(1):319. The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction. DOI: 10.1038/s41467-019-14082-5
- Nature Reviews Cancer. 2018 2018 Sep;18(9):562-575. Adapting to stress – chaperome networks in cancer. DOI: 10.1038/s41568-018-0020-9
- Nature. 2016 Oct 20;538(7625):397-401. The epichaperome is an integrated chaperome network that facilitates tumour survival. DOI: 10.1038/nature19807
- Cell Reports 2020 Jun 30;31(13):107840. Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone. DOI: 10.1016/j.celrep.2020.107840
- Nature Communications 2018 Oct 19;9(1):4345. HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons.
- NPJ Precision Oncology 2021 May 26;5(1):44. Targeting the epichaperome as an effective precision medicine approach in a novel PML-SYK fusion acute myeloid leukemia. DOI: 10.1038/s41698-021-00183-2
- JCO Precision Oncology 2020 Nov 17;4:PO.20.00273. Measuring Tumor Epichaperome Expression Using [124I] PU-H71 Positron Emission Tomography as a Biomarker of Response for PU-H71 Plus Nab-Paclitaxel in HER2-Negative Metastatic Breast Cancer. DOI: 10.1200/PO.20.00273
The successful candidate will:
- Have up to five years of postdoctoral experience with a demonstrated competence and experience in the biology of cancer or neurodegenerative disorders.
- Have demonstrated ability to work independently and lead projects while also collaborating and assisting the group achieve its research goals
Candidates with an ability to interact well with a large interdisciplinary team are encouraged to apply.
- A strong desire to impact human disease
- Creativity in problem solving and a team spirit
- Knowledge of standard molecular and cell biology methods
- Good communication/written skills
- Passion for science, and flexibility to work some evenings and weekends
- Ability to work towards defined goals in an efficient, safe and scientifically sound manner.
Memorial Sloan-Kettering Cancer Center is located in New York, in Manhattan’s Upper East Side, adjacent to the Cornell University Weill Medical College and the Rockefeller University. This rich scientific environment provides many unique and unparalleled research training opportunities (www.mskcc.org/education-training/postdoctoral)