Chemical Biology Program

The Gabriela Chiosis Lab

Research

Pictured: Gabriela Chiosis
Gabriela Chiosis, PhD

The goal of my program is to investigate stressor maladaptation mechanisms such as they occur in several diseases. Our approach takes advantage of the way nature has evolved to control such stressors, and that is by a unique usage of the chaperome, referred here as the epichaperome. The epichaperome, which we discovered, is structurally, dynamically and functionally distinct from the housekeeping chaperome, and my lab has pioneered an approach to take advantage of such features. By using innovative methods, we develop small molecule chemical toolsets specifically targeted to the epichaperome; these act as “sensors” of the epichaperome, and in turn, of the chronic stressor-associated proteome-wide malfunctions. By the use of these unique toolsets we aim to understand, diagnose and treat cellular processes associated with chronic stressors. We address multiple mechanistic and biochemical questions less amenable to approaches that treat the chaperome as monolithic entity (i.e. the classical biochemical and genetic tools). We investigate in endogenous systems, both at the cellular and the organismal level, the inherent proteome changes and mechanisms that lead to disease, i.e. we can understand. By sensing disease states through the chemical toolsets, we go beyond investigation; we identify, measure and quantify, i.e. we can diagnose. By attacking the epichaperome specifically, we perturb the disease-causing proteome, and in turn revert or slow the disease phenotype, i.e. we can treat.

To summarize, we use a unique chemical biology approach to understand, diagnose and treat cellular processes associated with chronic cellular stress. My research group is interdisciplinary, and functions with the understanding that we are able to discover and synthesize pharmacological agents, determine their mechanisms of action and significance in disease treatment, and ultimately develop rational strategies for their use in clinic. Soon after joining the lab, trainees are exposed to views from colleagues with diverse backgrounds, and start to see problems from a new perspective, developing their understanding of disease and of ways to combat it. They also learn to approach projects in a collaborative and interdisciplinary manner, which we believe, are key to our success in the discovery and translation of novel diagnostics and therapeutics.

To successfully function in such diverse research interests, the lab relies on the services and input of several dedicated facilities available through the Tri-institutional program (MSKCC, Weill Cornell Medicine, Rockefeller U). It has also established a strong interdisciplinary and synergistic network of collaborations to facilitate the translation of our findings from bench to bedside, in both cancer and Alzheimer’s disease. Through my dual appointment in the Department of Medicine and the Program in Chemical Biology, I have direct contact with and play a bridging role between the basic scientists and clinicians involved in these interdisciplinary efforts.

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Research Projects

Pictured: Chiosis Lab

Chiosis Lab - October 2013

Publications

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People

Pictured: Gabriela Chiosis

Gabriela Chiosis, PhD

  • The Chiosis lab uses a unique chemical biology approach to understand, diagnose, and treat cellular processes associated with chronic molecular stress, with the ultimate goal of developing novel therapeutic options for use in the clinic.
  • PhD, Columbia University
chiosisg@mskcc.org
Email Address
646-888-2235
Office Phone

Members

Anna Rodina

Senior Research Scientist

Tony Taldone

Senior Research Scientist

Tai Wang
Tai Wang

Bioinformatics Consultant

Pengrong Yan

Senior Research Scientist

Suhasini Joshi

Senior Research Scientist

Alexander Bolaender

Research Scholar

Sahil Sharma

Research Fellow

Palak Panchal

Research Technician

Jenny Matalon

Administrative Assistant

Chander Digwal

Research Fellow - Medicinal Chemist

Anand Santha Seela

Research Scholar

Lab Alumni
Erica DaGama Gomes

Research Fellow

Sarah Kishinevsky

Graduate Student

John Koren

Research Scholar

Stefan Ochiana

Research Scholar

Hardik Patel

Research Scholar

Smit Shah
Smit Shah

Research Technician

Mohammad Uddin

Research Technician

Maria del Carmen Inda Garcia, PhD
Maria del Carmen Inda Garcia

Research Scholar

Chao Xu, PhD
Chao Xu

Research Fellow

Chenghua Yang

Research Scholar

Srinivasa Gandu
Srinivasa Gandu

Research Technician

Lampros Milanos, PhD
Lampros Milanos

Research Fellow

Fumiko Shimizu, PhD
Fumiko Shimizu
Mary Alpaugh

Research Associate

Liza Shrestha, PhD
Liza Shrestha

Research Fellow

Raul Alonso

Research Technician

Lab Affiliations

Achievements

AACR – Cancer Research and Prevention Career Development Award in Translational Lung Cancer Research, in Memory of Duffy Wall

Susan G. Komen Breast Cancer Translational Research Award

Frederick R. Adler Chair for Junior Faculty

Award for Drug Discovery Research for Frontotemporal Dementia

Top 5 percent cited author in Biology and Biochemistry 2010 (analysis by Thomson Reuters)

Translated from bench-to-bedside the Hsp90 inhibitor PU-H71 and the non-invasive companion diagnostic 124I-PU-H71 PET assay

Lab News & Events

Open Positions

Bioinformatics postdoctoral scientist

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Postdoctoral researcher - Medicinal Chemistry and/or Chemical Biology

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Postdoctoral researcher-translational research/biomedicine

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Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Gabriela Chiosis discloses the following relationships and financial interests:

  • Samus Therapeutics LLC
    Fiduciary Role/Position; Intellectual Property Rights; Ownership / Equity Interests

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.


This page and data include information for a specific MSK annual disclosure period (January 1, 2020 through disclosure submission in spring 2021). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.


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