I am examining the mechanisms which allow some cancer-cell models to survive following Hsp90 inhibition. These studies cover cancer biology, basic Hsp90 biochemistry, signal transduction, and pharmacology.
I am also studying the effects of a unique blood-brain barrier permeable Hsp90 inhibitor as a therapeutic option for neurodegenerative diseases. These studies include neurobiology, animal behavior analysis, and basic neural-biochemistry.
University of Notre Dame | ND · Warren Family Research Center for Drug Discovery and Development