I completed my PhD training on the role and regulation of Scaffold/Matrix Attachment Region Binding Protein (SMAR1), an important epigenetic modulator and tumour suppressor, in oral, ovarian, and cervical cancer from Indian Institute of Chemical Biology (IICB), Kolkata, West Bengal. During my PhD training, I deciphered how SMAR1 modulates the transcriptome of cancers in a way to halt tumour progression. As cancer cells utilize different strategies to downregulate SMAR1 at both the RNA and protein levels, I aimed at identifying such factors and discovered Pim1 Kinase as one of the negative regulators of SMAR1. Alongside this in collaboration I have worked on various chemical tools to comprehend the function of G-quadruplexes in transcriptional regulation.
Presently, I am working under the supervision of Prof. Gabriela Chiosis on the functions of the hyperconnected HSP90 protein networks called “epichaperome” in cancer cell survival. Disruption of the epichaperome leads to tumour regression. My aim is to utilize PUH71, a small molecule inhibitor of epichaperome to disrupt this hyperconnected network in tumours, in synergism with other chemotherapeutic drugs to improve cancer patient survival.