Tanaya Roychowdhury

Research Scholar
Tanaya Roychowdhury

I completed my PhD training on the role and regulation of Scaffold/Matrix Attachment Region Binding Protein (SMAR1), an important epigenetic modulator and tumour suppressor, in oral, ovarian, and cervical cancer from Indian Institute of Chemical Biology (IICB), Kolkata, West Bengal. During my PhD training, I deciphered how SMAR1 modulates the transcriptome of cancers in a way to halt tumour progression. As cancer cells utilize different strategies to downregulate SMAR1 at both the RNA and protein levels, I aimed at identifying such factors and discovered Pim1 Kinase as one of the negative regulators of SMAR1. Alongside this in collaboration I have worked on various chemical tools to comprehend the function of G-quadruplexes in transcriptional regulation.

Presently, I am working under the supervision of Prof. Gabriela Chiosis on the functions of the hyperconnected HSP90 protein networks called “epichaperome” in cancer cell survival. Disruption of the epichaperome leads to tumour regression. My aim is to utilize PUH71, a small molecule inhibitor of epichaperome to disrupt this hyperconnected network in tumours, in synergism with other chemotherapeutic drugs to improve cancer patient survival.


  1. Nandi, S. K., Roychowdhury, T., Chattopadhyay, S., Basu, S., Chatterjee, K., Choudhury, P., … & Bhattacharya, R. (2022). Deregulation of the CD44-NANOG-MDR1 associated chemoresistance pathways of breast cancer stem cells potentiates the anti-cancer effect of Kaempferol in synergism with Verapamil. Toxicology and Applied Pharmacology, 115887.
  2. Yelisetty Venkata Suseela, Pallabi Sengupta, Tanaya Roychowdhury*, Suman Panda, Sangita Talukdar, Samit Chattopadhyay, Subhrangsu Chatterjee, and Thimmaiah Govindaraju. ACS Bio & Med Chem Au 0, 0, ppDOI: 10.1021/acsbiomedchemau.1c00039(*Joint First Author)
  3. Roy, A., Chatterjee, O., Banerjee, N., Roychowdhury, T., Dhar, G., Mukherjee, G., & Chatterjee, S. (2021). Curcumin arrests G-quadruplex in the nuclear hyper-sensitive III1 element of c-MYC oncogene leading to apoptosis in metastatic breast cancer cells. Journal of Biomolecular Structure and Dynamics, 1-17.
  4. Ghatak, D., Datta, A., Roychowdhury, T., Chattopadhyay, S., &Roychoudhury, S. (2021). MicroRNA-324-5p–CUEDC2 Axis Mediates Gain-of-Function Mutant p53-Driven Cancer Stemness. Molecular Cancer Research.
  5. Ghosh, A., Roychowdhury, T*., Nandi, R., Maiti, R., Ghosh, N. N., Molla, S. A., … &Maiti, D. K. (2021). Inhibitory role of a smart nano-trifattyglyceride of Moringa oleifera root in epithelial ovarian cancer, through attenuation of FSHR-c-Myc axis. Journal of Traditional and Complementary Medicine. (*Joint First author)
  6. Roychowdhury, T., & Chattopadhyay, S. (2020). Chemical Decorations of “MARs” Residents in Orchestrating Eukaryotic Gene Regulation. Frontiers in Cell and Developmental Biology8, 1545(Co-corresponding author)
  7. Sengupta, P., Banerjee, N., Roychowdhury, T., Dutta, A., Chattopadhyay, S. and Chatterjee, S., 2018. Site-specific amino acid substitution in dodecameric peptides determines the stability and unfolding of c-MYC quadruplex promoting apoptosis in cancer cells. Nucleic acids research46(19), pp.9932-9950.
  8. Alam, A., Taye, N., Patel, S., Thube, M., Mullick, J., Shah, V.K., Pant, R., Roychowdhury, T., Banerjee, N., Chatterjee, S. and Bhattacharya, R., 2019. SMAR1 favors immunosurveillance of cancer cells by modulating calnexin and MHC I expression. Neoplasia21(10), pp.945-962.
  9. Jana, J., Mondal, S., Bhattacharjee, P., Sengupta, P., Roychowdhury, T., Saha, P., Kundu, P. and Chatterjee, S., 2017. Chelerythrine down regulates expression of VEGFA, BCL2 and KRAS by arresting G-Quadruplex structures at their promoter regions. Scientific reports7, p.40706.