Memorial Hospital Research Laboratories
The Kayvan Keshari Lab
The goal of our research program is to improve our biochemical understanding of cancer metabolism and use metabolic changes to develop non-invasive methods for diagnosis as well as approaches to treat cancer. Our work takes advantage of multi-modality methods at all scales, with a special focus in hyperpolarized magnetic resonance, allowing us the ability to bring these approaches to the clinic.
Lees H, Millan M, Ahamed F, Eskandari R, Granlund KL, Jeong S, Keshari KR. (2020) Multi-sample measurement of hyperpolarized pyruvate-to-lactate flux in melanoma cells. NMR Biomed. :e4447. doi: 10.1002/nbm.4447. Online ahead of print.
Jeong S, Eskandari R, Park SM, Alvarez J, Tee SS, Weissleder R, Kharas MG, Lee H, Keshari KR. (2017) Real-time quantitative analysis of metabolic flux in live cells using a hyperpolarized micromagnetic resonance spectrometer. Sci Adv. Jun 16;3(6):e1700341
Salamanca-Cardona L, Shah H, Poot AJ, Correa FM, Di Gialleonardo V, Lui H, Miloushev VZ, Granlund KL, Tee SS, Cross JR, Thompson CB, Keshari KR. (2017) In vivo imaging of glutamine metabolism to the oncometabolite 2-hydroxyglutarate in IDH1/2 mutant tumors. Cell Metab. Dec. 5;26(6):830-841
Dong Y, Eskandari R, Ray C, Granlund K, Dos Santos-Cunha L, Miloushev V, Tee SS, Jeong S, Cheng EH, Hsieh JJ, Keshari KR. (2019) Hyperpolarized MRI Visualizes Warburg Effects and Predicts mTOR Inhibitor Treatment Response in Patient-Derived ccRCC Xenograft Models. Cancer Res. Jan. 1;79(1):242-250
Granlund KL, Tee SS, Vargas HA, Lyashenko SK, Reznik E, Fine S, Laudone V, Eastham JA, Touijer KA, Reuter VE, Gonen M, Sosoa RE, Nicholson D, Guo YW, Chen AP, Tropp J, Robb F, Hricak H, Keshari KR. (2019) Hyperpolarized MRI of Human Prostate Cancer Reveals Increased Lactate with Tumor Grade Driven by Monocarboxylate Transporter 1. Cell Metab. Sep;21(19):1550-4131
Kayvan R. Keshari, PhD
- Biochemist and imaging specialist Kayvan Keshari explores changes in cancer metabolism to develop advanced imaging techniques and cancer targets.
- BA, University of California, Berkeley
- PhD, University of North Carolina Chapel Hill
- NIH Pathway Independent Award 2012
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Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
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Kayvan R. Keshari discloses the following relationships and financial interests:
NVision Imaging Technologies GmbH
Ownership / Equity Interests; Provision of Services
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