Memorial Hospital Research Laboratories
The Kayvan Keshari Lab
The goal of our research program is to improve our biochemical understanding of cancer metabolism and use metabolic changes to develop non-invasive methods for diagnosis as well as approaches to treat cancer. Our work takes advantage of multi-modality methods at all scales, with a special focus in hyperpolarized magnetic resonance, allowing us the ability to bring these approaches to the clinic.
DeBerardinis, R. J., & Keshari, K. R. (2022). Metabolic analysis as a driver for discovery, diagnosis, and therapy. Cell, 185(15), 2678–2689. https://doi.org/10.1016/j.cell.2022.06.029
Tee, S. S., Kim, N., Cullen, Q., Eskandari, R., Mamakhanyan, A., Srouji, R. M., Chirayil, R., Jeong, S., Shakiba, M., Kastenhuber, E. R., Chen, S., Sigel, C., Lowe, S. W., Jarnagin, W. R., Thompson, C. B., Schietinger, A., & Keshari, K. R. (2022). Ketohexokinase-mediated fructose metabolism is lost in hepatocellular carcinoma and can be leveraged for metabolic imaging. Science advances, 8(14), eabm7985. https://doi.org/10.1126/sciadv.abm7985
Jeong, S., Savino, A. M., Chirayil, R., Barin, E., Cheng, Y., Park, S. M., Schurer, A., Mullarky, E., Cantley, L. C., Kharas, M. G., & Keshari, K. R. (2021). High Fructose Drives the Serine Synthesis Pathway in Acute Myeloid Leukemic Cells. Cell metabolism, 33(1), 145–159.e6. https://doi.org/10.1016/j.cmet.2020.12.005
Granlund, K. L., Tee, S. S., Vargas, H. A., Lyashchenko, S. K., Reznik, E., Fine, S., Laudone, V., Eastham, J. A., Touijer, K. A., Reuter, V. E., Gonen, M., Sosa, R. E., Nicholson, D., Guo, Y. W., Chen, A. P., Tropp, J., Robb, F., Hricak, H., & Keshari, K. R. (2020). Hyperpolarized MRI of Human Prostate Cancer Reveals Increased Lactate with Tumor Grade Driven by Monocarboxylate Transporter 1. Cell metabolism, 31(1), 105–114.e3. https://doi.org/10.1016/j.cmet.2019.08.024
Salamanca-Cardona, L., Shah, H., Poot, A. J., Correa, F. M., Di Gialleonardo, V., Lui, H., Miloushev, V. Z., Granlund, K. L., Tee, S. S., Cross, J. R., Thompson, C. B., & Keshari, K. R. (2017). In Vivo Imaging of Glutamine Metabolism to the Oncometabolite 2-Hydroxyglutarate in IDH1/2 Mutant Tumors. Cell metabolism, 26(6), 830–841.e3. https://doi.org/10.1016/j.cmet.2017.10.001
Kayvan R. Keshari, PhD
Fred Lebow Chair at MSK
- Biochemist and Bioengineer Kayvan Keshari explores changes in cancer metabolism to develop advanced imaging techniques and cancer therapeutics.
- BA, University of California, Berkeley
- PhD, University of North Carolina Chapel Hill
- NIH Pathway Independent Award 2012
To learn more about available postdoctoral opportunities, please visit our Career Center
To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs
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Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.
Kayvan R. Keshari discloses the following relationships and financial interests:
Atish Technologies, Inc.
Equity; Intellectual Property Rights
Bruker BioSpin GmbH
Professional Services and Activities (Uncompensated)
NVision Imaging Technologies GmbH
Equity; Professional Services and Activities
The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.
This page and data include information for a specific MSK annual disclosure period (January 1, 2022 through disclosure submission in spring 2023). This data reflects interests that may or may not still exist. This data is updated annually.