Our lab studies two fundamental aspects of biology that have broad implications for human health. The first research direction examines how cells faithfully duplicate their genomes and repair DNA lesions arising from endogenous and exogenous sources. The second direction focuses on how a protein modifier called SUMO mediates signal transduction, directs the DNA stress response, and dynamically regulates the functions of many proteins. We have implemented a versatile combination of molecular, genetic, biochemical, cell biological, and genomic/proteomic approaches toward answering these questions. Our current work aims to elucidate new underlying principles of the above processes, and reveal how they are integrated with other cellular functions to achieve cell proliferation under various conditions.
Xiaolan Zhao, PhD
Research FocusMolecular biologist Xiaolan Zhao studies chromosomal organization, genome integrity, DNA replication and repair, dynamic protein modification.
EducationPhD, Columbia University
- Peng XP, Lim S, Li, S, Marjavaara L, Chabes A, Zhao X (2018) Acute Smc5/6 depletion reveals its primary role in rDNA replication by restraining recombination at fork pausing sites PLoS Genet 14: e1007129
- Bonner, J.N., Choi ,K., Xue, X., Torres, N.T., Szakal, B., Wei, L., Wan, B., Arter, M., Matos, J., Sung, P., Brown, P.W., Branzei, D. and Zhao, X. (2016) Smc5/6 mediated sumoylation of the Sgs1-Top3-Rmi1 complex promotes removal of recombination intermediates. Cell Reports 16, 368-378.
- Bressler Scholar, Alfred W. Bressler Scholar Endowment Fund (2007-2010)
- Research Scholar, American Cancer Society (2012-2016)
- Scholar, Leukemia & Lymphoma Society (2013-2018)
- Discovery of the extensive SUMO-based DNA damage response
- Discovery of the connection between the nuclear pore complex and desumoylation