Our lab studies two fundamental aspects of biology that have broad implications for human health. The first research direction examines how cells faithfully duplicate their genomes and repair DNA lesions arising from endogenous and exogenous sources. The second direction focuses on how a protein modifier called SUMO mediates signal transduction, directs the DNA stress response, and dynamically regulates the functions of many proteins. We have implemented a versatile combination of molecular, genetic, biochemical, cell biological, and genomic/proteomic approaches toward answering these questions. Our current work aims to elucidate new underlying principles of the above processes, and reveal how they are integrated with other cellular functions to achieve cell proliferation under various conditions.
Xiaolan Zhao, PhD
Research FocusMolecular biologist Xiaolan Zhao studies chromosomal organization, genome integrity, DNA replication and repair, dynamic protein modification.
EducationPhD, Columbia University
- Wei, L., and Zhao, X. (2016). A new MCM modification cycle regulates DNA replication initiation. Nature Structural & Molecular Biology 23, 209–216.
- Hang, L.E., Peng, J., Tan, W., Szakal, B., Menolfi, D., Sheng, Z., Lobachev, K., Branzei, D., Feng, W., and Zhao, X. (2015). Rtt107 Is a Multi-functional Scaffold Supporting Replication Progression with Partner SUMO and Ubiquitin Ligases. Molecular Cell 60, 268-279.
- Bressler Scholar, Alfred W. Bressler Scholar Endowment Fund (2007-2010)
- Research Scholar, American Cancer Society (2012-2016)
- Scholar, Leukemia & Lymphoma Society (2013-2018)
- Discovery of the extensive SUMO-based DNA damage response
- Discovery of the connection between the nuclear pore complex and desumoylation
- Discovery of the Smc5/6 complex in budding yeast
- Discovery of the essential function of the DNA replication and damage checkpoint