Chemical biology involves the use of chemical principles and tools to solve pressing problems in biomedical research that are challenging to address using classical methods, such as those routinely used in cell biology, genetics, and biochemistry.

Scientists in the Sloan Kettering Institute’s Chemical Biology program are developing chemical technologies to discover new molecular probes, using those probes to dissect the complex functions and mechanisms of proteins and other biological targets, and leveraging that understanding to investigate novel therapeutics to treat human diseases.

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Specific research interests in the Chemical Biology Program include the following:

  • development of new synthetic methodologies and total synthesis of natural products and proteins
  • diversity-oriented synthesis of chemical libraries
  • rational design of enzyme inhibitors
  • activity-based protein profiling of enzyme families
  • mechanistic studies of small molecules and their targets
  • drug discovery and development

This work is often carried out through multidisciplinary collaborations with scientists from complementary disciplines. The overall goal of our research is to improve our understanding and treatment of cancer as well as neurodegenerative disorders and infectious diseases.