Scientists in the Sloan Kettering Institute’s Structural Biology Program aim to understand biological processes at the levels of molecular mechanisms and three-dimensional structures. The experimental tools we employ range from x-ray crystallography to super-resolution optical methods and are complemented by biochemical, cell biology, and genetic approaches. We are particularly interested in studying cancer-related proteins with the aim to facilitate the development of novel cancer therapies.

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The work of our researchers covers diverse areas of biology including DNA-damage response, epigenetic modification of DNA and histones, RNA silencing, RNA processing, DNA and RNA structure, riboswitches, transcription, and growth-regulatory pathways. In addition, we investigate cell-surface receptors, vesicular transport and secretion, post-translational protein modification by ubiquitin and ubiquitin-like proteins, and membrane protein structure and function.