My laboratory studies the natural killer (NK) cell and the molecules that control its ability to recognize and kill cancer and virally infected cells. Improved understanding of how NK cells behave is critical to advancing our ability to harness their innate capacity for tumor recognition and eradication. Therefore, an important component of my research focuses on the basic biology of the NK cell, identifying the molecules involved in controlling NK reactivity, and determining the laboratory and clinical conditions under which NK activity can be modified.
- Verneris M, Hoff GA, Fischer JC, Hsu K, Cooley S, Miller J, Wang T, Haagenson M, Spellman S, Lee SJ, Uhrberg M, Venstrom JM. Recipient HLA-C haplotypes and miRNA 148a/b binding sites have no impact on allogeneic hematopoietic cell transplantation outcomes. Biol Blood Marrow Transplant. 13 Oct 2016. [Epub ahead of print].
- Curran SA, Shyer JA, St. Angelo ET, Talbot LR, Sharma S, Chung DJ, Heller G, Hsu KC, Betts BC, Young JW. Human dendritic cells mitigate NK cell dysfunction mediated by nonselective JAK1/2 ?blockade. Cancer Immunol Research. In press.