My laboratory studies the natural killer (NK) cell and the molecules that control its ability to recognize and kill cancer and virally infected cells. Improved understanding of how NK cells behave is critical to advancing our ability to harness their innate capacity for tumor recognition and eradication. Therefore, an important component of my research focuses on the basic biology of the NK cell, identifying the molecules involved in controlling NK reactivity, and determining the laboratory and clinical conditions under which NK activity can be modified.
Katharine C. Hsu, MD, PhD
Professor of Medicine
Research FocusPhysician-scientist Katharine Hsu studies the biology of human natural killer cells and how they contribute to disease processes.
- Boudreau JE, Giglio F, Gooley TA, Stevenson PA, Le Luduec JB, Shaffer BC, Rajalingam R, Hou L, Hurley CK, Noreen H, Reed EF, Yu N, Vierra-Green C, Haagenson MD, Malkki M, Petersdorf EW, Spellman S, Hsu KC. KIR3DL1/HLA-B subtypes govern AML relapse after hematopoietic cell transplantation. J Clin Onc. 2017. 35(20):2268-2278.
- Lindsley RC, Saber W, Mar BG, Redd R, Wang T, Haagenson MD, Grauman PV, Hu Z-H, Spellman SR, Lee SJ, Verneris MR, Hsu K, Fleischhauer K, Cutler C, Antin JH, Neuberg D, Ebert BL. Genetic alterations predict outcomes in patients with myelodysplastic syndrome receiving allogeneic hematopoietic stem cell transplantation. N Engl J Med. 2017. 376:536-547.