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New roles for Notch signaling in the immune system.

… Dr. Maillard’s research focuses on the role of Notch signaling in hematopoiesis as well as in T and B cell development, differentiation and function. Through more than 15 years of research in the field, his laboratory discovered essential functions for Notch receptors and ligands in graft-versus-host

The Huangfu laboratory uses human pluripotent stem cells (hPSCs) as a powerful genetic model to interrogate the transcriptional and epigenetic mechanisms underlying cell fate decisions in development and disease.

… We apply both precision gene editing and large-scale CRISPR screening in human pluripotent stem cells (hPSCs) to explore mechanisms underlying human development. Specifically, we are interrogating the protein-coding regulators of pancreatic development and β cell function. The pathways that regulate

Molecular biologist Simon Powell investigates DNA replication and recombination, chromosome dynamics, and human genetics.

… The major theme of our work is how DNA repair processes are disrupted in human cancers and how this can be exploited therapeutically.   Join the Powell Lab! Simon N. Powell, MD, PhD Enid A. Haupt Chair in Radiation Oncology Professor PhD, MD, University of London Email [email protected] Laboratory phone