Head & Neck Cancers: Our Clinical Trials

Clinical trials are research studies that evaluate the safety and effectiveness of new treatment approaches for a disease. If you are being treated for a head and neck cancer, you may be offered the opportunity to take part in a clinical trial at some point during your treatment.

In some cases, a study may give you access to new therapies that are not yet readily available. Clinical trials may also be used to compare diagnostic tests, prevention strategies, or other aspects of your care.

If you are asked to participate in a clinical trial, your doctor or nurse will explain exactly what is involved and any possible benefits or drawbacks posed by the trial. They will explain to you that that unexpected side effects may occur if you enroll in a clinical trial. You will need to sign an informed consent agreement in order to participate in the trial. Before agreeing to participate, make sure you know what the costs will be and how much your insurance will cover.

You are not required to participate in clinical trials. If you decline, this will not jeopardize your relationship with your physician. You may leave a trial for any reason and at any time, even after signing the agreement.

Here you can find a continually updated listing of Memorial Sloan-Kettering's current clinical trials for head and neck cancers. To learn more about a study, choose from the list below.

Showing 14 trials
Title Investigator
A Phase I Study of Induction Chemotherapy with Afatinib, Ribavirin, and Carboplatin/Paclitaxel in Patients with Stage IV HPV-Associated Oropharynx Cancer
[Protocol 12-150]
Fury, Matthew, MD, PhD
A Phase I/II Study of Temsirolimus, Paclitaxel, and Carboplatin for Recurrent or Metastatic Head and Neck Squamous Cell Cancer
[Protocol 09-131]
Fury, Matthew, MD, PhD
A Phase II Study of Axitinib in Patients with Recurrent, Progressive/Metastatic Adenoid Cystic Cancer
[Protocol 12-004]
Ho, Alan, MD, PhD
A Phase II Study of Concurrent Radiation and Chemotherapy versus Radiation Alone in Resected High-Risk Malignant Salivary Gland Tumors
[Protocol 11-005]
Lee, Nancy, MD
A Phase II Study of MK-2206 in Patients with Progressive, Recurrent/Metastatic Adenoid Cystic Carcinoma
[Protocol 11-193]
Ho, Alan, MD, PhD
A Phase II Trial of Bevacizumab, Cetuximab, Cisplatin, and Intensity-Modulated Radiation Therapy for Patients with Stage III/IV Head and Neck Squamous Cell Carcinoma
[Protocol 09-083]
Fury, Matthew, MD, PhD
A Phase IIB Study of Pioglitazone for Oral Precancers
[Protocol 09-163]
Boyle, Jay, MD
A Phase III Study of Postoperative Radiation Therapy with and without Cetuximab for Locally Advanced Resected Head and Neck Cancer
[Protocol 10-081]
Lee, Nancy, MD
A Pilot Study of Sulindac, a Pan-COX Inhibitor, in Oral Premalignant Lesions
[Protocol 04-099]
Boyle, Jay, MD
A Pilot Study to Assess the Pharmacodynamic Effects of Ribavirin in Patients with Operable Tonsil Squamous Cell Carcinoma
[Protocol 10-218]
Fury, Matthew, MD, PhD
Development and Validation of a New Patient-Reported Outcome Instrument on the Impact of Altered Facial Appearance Following Oncologic Head and Neck Resection and Reconstruction
[Protocol 07-098]
Pusic, Andrea, MD, MHS
Feasibility Study Using Fluoro-Misonidazole Positron Emission Tomography to Detect Hypoxia in Head and Neck Cancer Patients
[Protocol 04-070]
Lee, Nancy, MD
Microvascular Reconstruction for Advanced-Stage Head and Neck Cancer Patients: A Prospective Analysis of Quality of Life and Symptom Relief
[Protocol 07-150]
Pusic, Andrea, MD, MHS
Surviving Oropharynx Cancer: Long-Term Impact of Human Papillomavirus on Quality of Life
[Protocol 10-111]
Baxi, Shrujal, MD