Clozaril; FazaClo; Versacloz
Apo-Clozapine; Clozaril; Gen-Clozapine
- This drug may lower the ability of your bone marrow to make white blood cells. This can lead to very bad and sometimes deadly infections. Use this drug only if your health problem has not been helped by other drugs or if you have planned to harm yourself in the past and have a chance of doing it again. You will need to have your blood work checked before, during, and after treatment is stopped. Do what the doctor tells you about blood tests while taking this drug.
- This drug may cause seizures in some people. The chance of seizures may be higher with higher doses or if you have ever had seizures. Use care when driving and doing other tasks or actions (like climbing and swimming) that may not be safe for you or others if you pass out.
- This drug may raise the chance of a very bad and sometimes deadly heart problem (myocarditis). Call your doctor right away if you have a big weight gain, a heartbeat that does not feel normal, chest pain or pressure, fast heartbeat, fever, flu-like signs, shortness of breath, swelling in the arms or legs, or very bad dizziness or passing out.
- Low blood pressure, passing out, slow heartbeat, and heart attacks have happened with this drug. These problems can be deadly. Do not take more than you were told or raise your dose faster than you were told. Tell your doctor if you have heart problems or brain problems. Tell your doctor if you have lots of fluid loss or if you take drugs for high blood pressure.
- There is a higher chance of death in older adults who take this drug for mental problems caused by dementia. Most of the deaths were linked to heart disease or infection. This drug is not approved to treat mental problems caused by dementia.
- It is used to treat schizophrenia.
- It is used to treat problems with how one acts.
- It may be given to you for other reasons. Talk with the doctor.
- If you have an allergy to clozapine or any other part of this drug.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you have a low white blood cell count.
- If you have any of these health problems: Low potassium or magnesium levels.
- If you have ever had a low white blood cell count when taking this drug before.
- Tell dentists, surgeons, and other doctors that you use this drug.
- To lower the chance of feeling dizzy or passing out, rise slowly over a few minutes when sitting or lying down. Be careful climbing stairs.
- If you have high blood sugar (diabetes), talk with your doctor. This drug may raise blood sugar.
- Tell your doctor if you have signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
- Check your blood sugar as you have been told by your doctor.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- You will need to have heart function tests while taking this drug. Talk with the doctor.
- If you start or stop smoking, talk with your doctor. How much drug you take may need to be changed.
- Blood clots have happened with this drug. Tell your doctor if you have ever had a blood clot. Talk with your doctor.
- Talk with your doctor before you drink alcohol or use other drugs and natural products that slow your actions.
- Tell your doctor if you use caffeine products (for example, tea, coffee, cola) and chocolate. How much of this drug you take may need to be changed.
- Be careful in hot weather or while being active. Drink lots of fluids to stop fluid loss.
- Women and people with a Jewish background may have a higher chance of blood problems with this drug. Talk with your doctor.
- This drug can cause very bad and sometimes deadly stomach or bowel problems like very hard stools (constipation) or bowel block. To help avoid these problems, drink lots of noncaffeine liquids unless told to drink less liquid by your doctor. Laxatives may also help. Talk with your doctor.
- Do not stop taking this drug all of a sudden without calling your doctor. You may have a greater risk of signs of withdrawal. If you need to stop this drug, you will want to slowly stop it as ordered by your doctor.
- Older adults with dementia taking drugs like this one have had a higher number of strokes. Sometimes these strokes have been deadly. This drug is not approved to treat mental problems caused by dementia. Talk with your doctor.
- If you are 65 or older, use this drug with care. You could have more side effects.
- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this drug while you are pregnant.
- Taking this drug in the third trimester of pregnancy may lead to muscle movements that cannot be controlled and withdrawal in the newborn. Talk with the doctor.
- Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
- If you have PKU, talk with your doctor. Some products have phenylalanine.
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
- Shakiness, trouble moving around, or stiffness.
- Change in strength on 1 side is greater than the other, trouble speaking or thinking, change in balance, or blurred eyesight.
- Swelling, warmth, numbness, change of color, or pain in a leg or arm.
- Coughing up blood.
- Blue or very pale skin in the arms or legs.
- Feeling very tired or weak.
- Change in eyesight.
- A very bad and sometimes deadly health problem called neuroleptic malignant syndrome (NMS) may happen. Call your doctor right away if you have any fever, muscle cramps or stiffness, dizziness, very bad headache, confusion, change in thinking, fast heartbeat, heartbeat that does not feel normal, or are sweating a lot.
- Some people who take this drug may get a very bad muscle problem called tardive dyskinesia. The risk may be greater in older adults, mainly women. The chance that this will happen or that it will never go away is greater in people who take this drug in higher doses or for a long time. Muscle problems may also occur after short-term use with low doses. Call your doctor right away if you have trouble controlling body movements or if you have muscle problems with your tongue, face, mouth, or jaw like tongue sticking out, puffing cheeks, mouth puckering, or chewing.
- Feeling sleepy.
- Hard stools (constipation).
- Dry mouth.
- Upset stomach or throwing up.
- Weight gain.
- Not able to sleep.
- Take with or without food.
- Take as you have been told, even if you feel well.
- To gain the most benefit, do not miss doses.
- Do not push the tablet out of the foil when opening. Use dry hands to take it from the foil. Place on your tongue and let it melt. Water is not needed. Do not swallow it whole. You may chew the tablet.
- Shake well before use.
- Measure liquid doses carefully. Use the measuring device that comes with this drug.
- Take a missed dose as soon as you think about it.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
- If you miss 2 or more days of this drug, call your doctor to find out how to restart.
- Store at room temperature. Do not refrigerate or freeze.
- Store in a dry place. Do not store in a bathroom.
- Protect from light.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Check with your pharmacist about how to throw out unused drugs.
- Store in pouch until ready for use.
- Use oral-disintegrating tablet right after opening. Throw away any part of opened pouch that is not used.
- Throw away any part not used 100 days after opening the first time.
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else’s drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
If you have any questions or concerns, talk with a member of your healthcare team. You can reach them Monday through Friday from 9:00 am to 5:00 pm at ____________________. After 5:00 pm, during the weekend, and on holidays, please call____________________. If there’s no number listed, or you’re not sure, call
Clozapine©2015 Memorial Sloan Kettering Cancer Center - Generated on October 10, 2015