Pegfilgrastim

Adult Medication

Brand Names: US

Neulasta; Neulasta Onpro

Brand Names: Canada

Neulasta

What is this drug used for?

  • It is used to lower the chance of getting an infection in people with bone marrow problems caused by chemo.
  • It is used in patients who have been exposed to certain doses of radiation.
  • It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take this drug?

All products:

  • If you have an allergy to this drug or any part of this drug.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have a latex allergy, talk with your doctor.

Prefilled syringes:

Children:

  • If your child weighs less than 99 pounds (45 kilograms), talk with your child’s doctor.
This drug may interact with other drugs or health problems.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take this drug?

All products:

  • Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.
  • Do not get this drug within 14 days before or on the same day that you get chemo. Talk with your doctor.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • Some people with sickle cell disease have had times where the sickle cell disease has gotten worse when taking this drug. Sometimes, this has been deadly. Talk with the doctor.
  • This drug may cause a very bad and sometimes deadly problem called capillary leak syndrome (CLS). CLS may lead to low blood pressure and harm to the body. It may also lead to a heartbeat that is not normal, chest pain or pressure, heart attack, lung or breathing problems, bleeding or lower blood flow in the stomach or bowel, kidney problems, swelling, or feeling confused. Talk with the doctor.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this drug while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

On-body Injector:

  • If you are allergic to acrylics, talk with your doctor.
  • If you are using the On-Body Injector: Do not travel, drive, or do other tasks or actions that require alertness during hours 26 through 29 after the Injector is put on. Be sure you understand how the Injector works, what tasks and actions to avoid, and when to avoid them. Be sure you know how to tell if all of the drug has been given or if there has been a problem with the Injector. Talk with your doctor.
  • You will need to avoid some things while using the On-body Injector like airport X-ray scans, sleeping on or putting pressure on it, bumping it, and getting skin products near it. Keep the On-body Injector at least 4 inches away from electrical equipment like phones and microwaves. Do not peel off the sticky part before your dose has been given.
  • Tell your doctor you have this drug on before you have certain exams like MRIs, X-rays, CT-scans, and ultrasounds.
  • Avoid use of heat sources (such as sunlamps, tanning beds, heating pads, electric blankets, heat lamps, saunas, hot tubs, heated waterbeds). Avoid long, hot baths or sunbathing. Your temperature may rise and cause too much drug to pass into your body.
  • This drug is not approved for use in children. Talk with the doctor.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
  • Dark urine.
  • A fast heartbeat.
  • Dizziness or passing out.
  • Sweating a lot.
  • Shortness of breath.
  • Fast breathing.
  • Fever.
  • Feeling very tired or weak.
  • Swelling.
  • Enlarged and ruptured spleens have happened with this drug. Sometimes, ruptured spleens have been deadly. Call your doctor right away if you have left upper stomach pain or left shoulder pain.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

All products:

  • Bone pain.
  • Muscle pain.

Prefilled syringes:

  • Pain and redness may happen where the shot was given. If you have a lump, swelling, or bruising that does not go away, call your doctor.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to your national health agency.

How is this drug best taken?

Use this drug as ordered by your doctor. Read all information given to you. Follow all instructions closely.

All products:

  • Follow how to use as you have been told by the doctor or read the package insert.

Prefilled syringes:

  • It is given as a shot into the fatty part of the skin.
  • Keep taking this drug as you have been told by your doctor or other health care provider, even if you feel well.
  • To gain the most benefit, do not miss doses.
  • If you will be giving yourself the shot, your doctor or nurse will teach you how to give the shot.
  • Leave this drug at room temperature for at least 30 minutes before using. Do not remove the cap or cover until ready to use. Do not heat this drug.
  • Do not use if the solution is cloudy, leaking, or has particles.
  • Do not use if solution changes color.
  • Do not shake the solution.
  • Wash your hands before and after use.
  • Do not give into skin that is irritated, bruised, red, infected, or scarred.
  • Move the site where you give the shot with each shot.
  • Throw away any part left over after the dose is given.
  • Throw syringe away after use. Do not use the same syringe more than one time.
  • Throw away needles in a needle/sharp disposal box. Do not reuse needles or other items. When the box is full, follow all local rules for getting rid of it. Talk with a doctor or pharmacist if you have any questions.

On-body Injector:

  • Your doctor will put on the skin.
  • Call the doctor right away if the On-body Injector comes off before or during a dose, if it is leaking, or if the sticky part is wet. Call the doctor right away if the light on the On-body Injector flashes red.

What do I do if I miss a dose?

  • Call your doctor to find out what to do.

How do I store and/or throw out this drug?

All products:

  • Store in a refrigerator. Do not freeze.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.

Prefilled syringes:

  • Protect from light.
  • If this drug freezes, let it thaw in the refrigerator before use.
  • Do not use if this drug has been frozen more than once.
  • If needed, this drug can be left out at room temperature for up to 48 hours. Throw away unopened drug if left at room temperature for more than 48 hours.

On-body Injector:

  • If needed, this drug can be left out at room temperature for up to 12 hours before use. Throw away any part not used after 12 hours.

General drug facts

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else’s drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Last Reviewed Date

2016-05-31

Copyright

© 2016 Wolters Kluwer Clinical Drug Information, Inc. and its affiliates and/or licensors. All rights reserved.