This information from Lexicomp® explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider.
- Life-threatening meningococcal infections have happened with this drug. This type of infection can become life-threatening very fast and can be deadly if not treated early. You will need to get a meningococcal vaccine at least 2 weeks before starting this drug unless your doctor tells you otherwise. If you have had a meningococcal vaccine before, you may need to get another one. Talk with your doctor if you have questions.
- Meningococcal vaccines lower the risk of meningococcal infections; they may not get rid of the risk of these infections. If you have questions, talk with the doctor.
- It is used to treat a blood disease called paroxysmal nocturnal hemoglobinuria (PNH).
- It is used to treat a blood and kidney disease called atypical hemolytic uremic syndrome (aHUS).
- If you are allergic to this drug; any part of this drug; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
- If you did not get a meningococcal vaccine.
- If you have a meningococcal infection.
- If you are breast-feeding. Do not breast-feed while you take this drug and for 8 months after your last dose.
This is not a list of all drugs or health problems that interact with this drug.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
- Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.
- You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
- The chance of gonorrhea infections may be raised in some people. Talk to your doctor to see if you have a greater chance of gonorrhea, how to prevent gonorrhea, and if you need to get tested.
- Make sure you are up to date with all your vaccines before treatment with this drug.
- Have patient safety card with you at all times and for 8 months after drug is stopped.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- If your weight changes, talk with your doctor. The dose of this drug may need to be changed.
- Some people have had side effects during the infusion. Tell your doctor if you have any side effects during the infusion.
- Some health problems may happen after this drug is stopped. You will need to be watched closely for several weeks to months after you stop this drug. Follow up with your doctor. Call your doctor right away if you have a change in how much urine is passed; dark urine; swelling, warmth, or pain in the leg or arm; chest pain or pressure; coughing up blood; trouble breathing or swallowing; any unexplained bruising or bleeding; seizures; stomach pain; severe dizziness; or passing out. Call your doctor right away if you feel confused, very tired or weak, or have weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on 1 side of the face, or change in eyesight. Call your doctor right away if you are not able to get or keep an erection.
- If the patient is a child, use this drug with care. The risk of certain severe infections may be raised in children.
- You may need to use birth control to prevent pregnancy while you take this drug and for some time after your last dose. Talk with your doctor to see if you need to use birth control.
- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this drug while you are pregnant.
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
- Signs of a meningococcal infection like very bad headache with or without upset stomach, throwing up, fever, or stiff neck or back; confusion; high fever; fever with a rash; if light bothers the eyes; or very bad muscle aches or pain with or without flu-like signs.
- Signs of high or low blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
- Signs of low potassium levels like muscle pain or weakness, muscle cramps, or a heartbeat that does not feel normal.
- Chest pain.
- Shortness of breath.
- Swelling in the arms or legs.
- Back pain.
- Pain and irritation where this drug goes into the body.
- Swollen gland.
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Signs of a common cold.
- Constipation, diarrhea, stomach pain, upset stomach, throwing up, or feeling less hungry.
- Pain in arms or legs.
- Feeling dizzy, tired, or weak.
- Muscle or joint pain.
- Muscle spasm.
- Hair loss.
- Dry skin.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to your national health agency.
Use this drug as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- It is given as an infusion into a vein over a period of time.
- Call your doctor to find out what to do.
- If you need to store this drug at home, talk with your doctor, nurse, or pharmacist about how to store it.
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else’s drugs.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
- Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
- This drug comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time this drug is refilled. If you have any questions about this drug, please talk with the doctor, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
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