Metabolic Regulation of Immune Cell Fate Decisions

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The ability of T-cells to control tumor growth is limited by the loss of proliferative capacity within the tumor microenvironment, but the mechanisms by which this occurs have remained unclear.  I will discuss how chronic antigenic stimulation-dependent reprogramming of T-cell metabolism drives terminal T-cell dysfunction and limits response to immune checkpoint blockade.  Chronic T-cell stimulation-driven impairment of ADP-coupled oxidative phosphorylation is necessary and sufficient to restrict T-cell self-renewal and activate an exhaustion-associated gene expression program.  Understanding how shifts in metabolic behavior govern T-cell fate decisions will enable development of novel strategies to enhance the depth and durability of anti-tumor immune responses.

(Refreshments will be served at 2:45 pm)

Date & Time(s)

Location

Memorial Sloan Kettering Cancer Center
Zuckerman Research Center
417 East 68th Street
Room ZRC-105
New York, NY 10065

Contact

For more information, please contact Emily Delgado @ delgadoe@mskcc.org

Host(s)

Human Oncology & Pathogenesis Program

Speaker(s)

Santosha Vardhana, MD, PhD
Assistant Professor
Lymphoma Service, Department of Medicine
Post-Doctoral Fellow, Craig Thompson Laboratory
Memorial Sloan Kettering Cancer Center