Cell Metabolism
Overview
This core was founded using philanthropic funding (2013-2019) and is motivated by a maturation in the technologies with which to interrogate cellular metabolism, growing expertise within the group, increasing demand for metabolomic analyses among investigators, and the need to incorporate this key aspect of cancer biology into the Center’s strategic framework for leading pioneering research. The laboratory operates a technology platform that is being leveraged by basic, translational, and clinical research groups across MSK. The Core provides a reservoir of knowledge in the development and implementation of cutting-edge analytical strategies with experienced scientific staff who assist in leveraging these analytical capabilities. The Core offers routine metabolomic and lipidomic profiling, provides advice on study design, sample preparation, and the choice of experimental approaches. The Core also assists extensively with data analysis and interpretation. Since 2020, the Core Director has also served as the Program co-Director for an NIH R25 Research Education Program that provides training in current metabolomics and lipidomics strategies for trainees at MSK and neighboring NYC metro area institutions.
Featured News


Publications
Ryu, K. W.; Fung, T. S.; Baker, D. C.; Saoi, M.; Park, J.; Febres-Aldana, C. A.; Aly, R. G.; Cui, R.; Sharma, A.; Fu, Y.; Jones, O. L.; Cai, X.; Pasolli, H. A.; Cross, J. R.; Rudin, C. M.; Thompson, C. B. Cellular ATP demand creates metabolically distinct subpopulations of mitochondria. Nature 2024, 635 (8039), 746–754. https://doi.org/10.1038/s41586-024-08146-w.
Paredes, J.; Fei, T.; Dai, A.; Ramos, R.; Adintori, P.; Kousa, A.; Nguyen, C. L.; Victor, K.; Ghale, R.; Pohl, C.; Elias, H. K.; Miltiadous, O.; Monette, S.; Gradissimo, A.; Cross, J.; Peled, J. U.; Da Silva, M. B.; Van Den Brink, M. R. M. Increased fiber intake results in better overall survival and lower GI-AGVHD in Allo-HCT recipients and Pre-Clinical GVHD models. Blood 2024, 144 (Supplement 1), 259. https://doi.org/10.1182/blood-2024-204399.
Qiu, Y.; Stamatatos, O. T.; Hu, Q.; Swain, J. R.; Russo, S.; Sann, A.; Costa, A. S. H.; Violante, S.; Spector, D. L.; Cross, J. R.; Lukey, M. J. The unique catalytic properties of PSAT1 mediate metabolic adaptation to glutamine blockade. Nature Metabolism 2024, 6 (8), 1529–1548. https://doi.org/10.1038/s42255-024-01104-w.
Winer, B. Y.; Settle, A. H.; Yakimov, A. M.; Jeronimo, C.; Lazarov, T.; Tipping, M.; Saoi, M.; Sawh, A.; Sepp, A.-L. L.; Galiano, M.; Perry, J. S. A.; Wong, Y. Y.; Geissmann, F.; Cross, J.; Zhou, T.; Kam, L. C.; Pasolli, H. A.; Hohl, T.; Cyster, J. G.; Weiner, O. D.; Huse, M. Plasma membrane abundance dictates phagocytic capacity and functional cross-talk in myeloid cells. Science Immunology 2024, 9 (96). https://doi.org/10.1126/sciimmunol.adl2388.
Pan, X.; Heacock, M. L.; Abdulaziz, E. N.; Violante, S.; Zuckerman, A. L.; Shrestha, N.; Yao, C.; Goodman, R. P.; Cross, J. R.; Cracan, V. A genetically encoded tool to increase cellular NADH/NAD+ ratio in living cells. Nature Chemical Biology 2023, 20 (5), 594–604. https://doi.org/10.1038/s41589-023-01460-w.
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Metabolomics Specialist I

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Scientific Research Lead

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Metabolomics Specialist I

Metabolomics Specialist I

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Senior Research Assistant

Metabolomics Specialist I

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Visiting Scientist—University of Toronto

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Postdoctoral Research Fellow

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Open Positions
To learn more about available postdoctoral opportunities, please visit our Career Center
Job Opportunities
The Donald B. and Catherine C. Marron Cancer Metabolism Center welcomes applications from highly motivated individuals with a proven track record LC-MS and strong interest in metabolic characterization of biological systems.
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