Cell Metabolism
Overview

The Cell Metabolism core, part of the Donald B. and Catherine C. Marron Cancer Metabolism Center, is dedicated to advancing research programs at Memorial Sloan Kettering by providing expertise in small molecule analysis (<2000 Da). We collaborate with investigators on diverse projects, leveraging advanced analytical platforms like GC-MS and LC-MS, alongside non-MS technologies, to address targeted and untargeted metabolomics questions tailored to specific research needs. Our methods enable precise measurement of metabolites, uncovering differential expression, identifying biomarkers, and characterizing metabolic pathways to unravel key biological insights. Beyond research, we are committed to education, offering workshops, hands-on training, and collaborative learning initiatives to empower researchers, foster creativity, and drive innovation in the field.

Members of the Donald B. and Catherine C. Marron Cancer Metabolism Center
Featured News


Publications
Ryu, K. W.; Fung, T. S.; Baker, D. C.; Saoi, M.; Park, J.; Febres-Aldana, C. A.; Aly, R. G.; Cui, R.; Sharma, A.; Fu, Y.; Jones, O. L.; Cai, X.; Pasolli, H. A.; Cross, J. R.; Rudin, C. M.; Thompson, C. B. Cellular ATP demand creates metabolically distinct subpopulations of mitochondria. Nature 2024, 635 (8039), 746–754. https://doi.org/10.1038/s41586-024-08146-w.
Paredes, J.; Fei, T.; Dai, A.; Ramos, R.; Adintori, P.; Kousa, A.; Nguyen, C. L.; Victor, K.; Ghale, R.; Pohl, C.; Elias, H. K.; Miltiadous, O.; Monette, S.; Gradissimo, A.; Cross, J.; Peled, J. U.; Da Silva, M. B.; Van Den Brink, M. R. M. Increased fiber intake results in better overall survival and lower GI-AGVHD in Allo-HCT recipients and Pre-Clinical GVHD models. Blood 2024, 144 (Supplement 1), 259. https://doi.org/10.1182/blood-2024-204399.
Qiu, Y.; Stamatatos, O. T.; Hu, Q.; Swain, J. R.; Russo, S.; Sann, A.; Costa, A. S. H.; Violante, S.; Spector, D. L.; Cross, J. R.; Lukey, M. J. The unique catalytic properties of PSAT1 mediate metabolic adaptation to glutamine blockade. Nature Metabolism 2024, 6 (8), 1529–1548. https://doi.org/10.1038/s42255-024-01104-w.
Winer, B. Y.; Settle, A. H.; Yakimov, A. M.; Jeronimo, C.; Lazarov, T.; Tipping, M.; Saoi, M.; Sawh, A.; Sepp, A.-L. L.; Galiano, M.; Perry, J. S. A.; Wong, Y. Y.; Geissmann, F.; Cross, J.; Zhou, T.; Kam, L. C.; Pasolli, H. A.; Hohl, T.; Cyster, J. G.; Weiner, O. D.; Huse, M. Plasma membrane abundance dictates phagocytic capacity and functional cross-talk in myeloid cells. Science Immunology 2024, 9 (96). https://doi.org/10.1126/sciimmunol.adl2388.
Pan, X.; Heacock, M. L.; Abdulaziz, E. N.; Violante, S.; Zuckerman, A. L.; Shrestha, N.; Yao, C.; Goodman, R. P.; Cross, J. R.; Cracan, V. A genetically encoded tool to increase cellular NADH/NAD+ ratio in living cells. Nature Chemical Biology 2023, 20 (5), 594–604. https://doi.org/10.1038/s41589-023-01460-w.
People

- 646-888-3317
- Office Phone

Director
Members






Metabolomics Specialist I

Metabolomics Specialist II

Scientific Research Lead

Research Technician

Metabolomics Specialist I

Metabolomics Specialist I

Research Technician

Research Technician



Alumni

Research Technician

Senior Research Assistant

Metabolomics Specialist I

Senior Research Scientist


Senior Research Scientist

Research Technician

Senior Research Scientist

Senior Research Scientist

Research Technician

Research Technician

Visiting Scientist—University of Toronto

Research Scientist

Research Technician

Senior Research Scientist

Research Technician

Postdoctoral Research Fellow

Research Scientist

Senior Research Scientist
Open Positions
To learn more about available postdoctoral opportunities, please visit our Career Center
Job Opportunities
The Donald B. and Catherine C. Marron Cancer Metabolism Center welcomes applications from highly motivated individuals with a proven track record LC-MS and strong interest in metabolic characterization of biological systems.
Get in Touch
-
Director Email