Ellen Hukkelhoven, PhD

Managing Director at Perceptive Advisors, New York, NY

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Ellen Hukkelhoven, PhD

Managing Director at Perceptive Advisors, New York, NY

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Ellen Hukkelhoven

Dissertation

Phosphorylation – dependent Regulation of the Tumor Suppressor TRIM3 (2013)

Mentor

Andrew Koff, PhD

Start Year

2008

End Year

2013

Education

BA, Princeton University

Publications

Hukkelhoven E, Liu Y, Yeh N, Ciznadija D, Blain SW, Koff A. (2012). Tyrosine phosphorylation of the p21 cyclin-dependent kinase inhibitor facilitates the development of proneural glioma. J Biol Chem., 287, 38523-30. PMCID: PMC3493897.

Gong Y, Zack TI, Morris LG, Lin K, Hukkelhoven E, Raheja R, Tan IL, Turcan S, Veeriah S, Meng S, Viale A, Schumacher SE, Palmedo P, Beroukhim R, Chan TA. (2014) Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins. Nat Genet. 46, 588-94. PMCID: PMC4251771

Raheja R, Liu Y, Hukkelhoven E, Yeh N, Koff A. (2014). The ability of TRIM3 to induce growth arrest depends on RING-dependent E3 ligase activity. Biochem J., 458, 537-45. PMCID: PMC4404499

Liu Y, Raheja R, Yeh N, Ciznadija D, Pedraza AM, Ozawa T, Hukkelhoven E, Erdjument-Bromage H, Tempst P, Gauthier NP, Brennan C, Holland EC, Koff A. (2014). TRIM3, a tumor suppressor linked to regulation of p21(Waf1/Cip1.). Oncogene.33, 308-15. PMCID: PMC3928554