Simone was born and raised in Florence, Italy, where he obtained his Bachelor and Masters in Medical biology. After a research internship at the Karolisnka Institute in Stockholm, Simone moved to Switzerland for doctoral training in the laboratory of Antonio Lanzavecchia and Federica Sallusto, where he investigated the functional heterogeneity of human memory CD4 T cells. At the end of 2014 Simone joined the laboratory of Eric Pamer at Memorial Sloan-Kettering, where he focused on the interactions between gut microbiota and immune system. In July 2019 Simone transitioned to the Hohl lab. Outside the lab, Simone enjoys playing with his two kids, working out and drinking good wine.