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Mysterious circular DNA may contribute to neuroblastoma and other childhood cancers.

… Monday, December 16, 2019 Summary Researchers have long been puzzled by rings of DNA that lie outside chromosomes in cells. A new study suggests that DNA from these circles inserts itself into chromosomes and triggers the uncontrolled cell growth that is the hallmark of cancer. People typically visualize

Updated survival outcomes from the EMBER-3 trial reinforced the clinical benefit of imlunestrant-based regimens as all-oral, chemotherapy-free treatment options for endocrine-pretreated patients with estrogen receptor-positive, human epidermal growth factor receptor 2-negative advanced or metastatic breast cancer. Breast medical oncologist Komal Jhaveri, MD, FACP, presented the latest results for the trial at SABCS, and was also the lead and corresponding author of the paper published simultaneously in the Annals of Oncology.

… Friday, December 12, 2025 Updated survival outcomes from the EMBER-3 trial reinforced the clinical benefit of imlunestrant as monotherapy and in combination with abemaciclib as oral, chemotherapy-free treatment options for patients with estrogen receptor (ER)-positive, human epidermal growth factor receptor

Researchers devised a novel method to ferry drugs to head and neck cancers using nanoparticles that naturally stick to a protein in tumor blood vessels.

… Tuesday, February 21, 2017 Summary The most effective drugs being tested for head and neck cancers , which target a pathway called PI3K, have dangerous side effects. MSK researchers developed a way to use nanoparticles to deliver these drugs precisely to the tumor site, allowing lower doses to be used

The United States Preventive Services Task Force released updated draft recommendations on colorectal cancer screening which, among other things, call for screening for the general population to begin at age 45.

… Tuesday, October 27, 2020 The United States Preventive Services Task Force released updated draft recommendations on colorectal cancer screening which, among other things, call for screening for the general population to begin at age 45.  Currently the recommendations for those at average risk for the

Recently developed targeted drugs used to treat lung cancer are only partially effective. Scientists now know why.

… Wednesday, January 8, 2020 Summary Scientists at Memorial Sloan Kettering have discovered why certain drugs used to treat lung cancer are only partially effective. The findings point to combination therapies that might overcome this limitation. Among cancer biologists, finding a drug that can target

近期开发的用于治疗肺癌的靶向药物只是部分有效。而如今科学家发现了其中的原因。

… Wednesday, January 8, 2020 总结 纪念斯隆凯特琳癌症中心的科学家发现了为什么某些用于治疗 肺癌 的药物只是部分有效。研究结果表明，联合疗法也许能克服这一局限性。 对于癌症生物学家而言，他们一直致力于找到一种能靶向 KRAS 蛋白的药物。 KRAS 是癌症中最常见的突变蛋白之一，但直到最近人们还认为它基本上是不可药物治疗的——近乎球形的结构使其成为一个非常光滑的靶点。但在过去的几年中，科学家已发现用于阻止一种特定 KRAS 突变（KRAS G12C）的方法。蛋白质在“启动”和“关闭”之间循环，产生细微的形状变化，使得被称为 KRAS G12C 抑制剂的药物能够与之结合并使其失效

Memorial Sloan Kettering Cancer Center announces the appointments of medical oncologist Anas Younes, surgical pathologist David S. Kimstra, surgeon Julio Garcia-Aguilar, and radiologist Wolfgang Weber.

… Tuesday, March 5, 2013 Memorial Sloan Kettering Cancer Center announces the following appointments: Anas Younes, MD , has been named Chief of the Lymphoma Service in the Division of Hematologic Oncology, Department of Medicine. An internationally recognized medical oncologist with more than two decades

Researchers clarify how the immune system activates an inflammatory defense against pathogens.

… Thursday, April 18, 2019 Summary Pyroptosis is a form of inflammatory cell death launched by protein complexes called inflammasomes. Scientists have identified how an inflammasome called NLRP1B activates pyroptosis in immune cells to defend against anthrax infection. This sheds light on an important

David A. Scheinberg has been elected a member of the prestigious Association of American Physicians (AAP).

… Friday, May 1, 2009 Summary David A. Scheinberg has been elected a member of the prestigious Association of American Physicians (AAP). David A. Scheinberg has been elected a member of the prestigious Association of American Physicians (AAP). Dr. Scheinberg is a physician-scientist involved in both basic

MSK studies look at the role of RNA splicing factors in acute myeloid leukemia and melanoma.

… Wednesday, October 9, 2019 Summary Two studies looked at the role of specific RNA splicing factors in different cancers. These factors help regulate how proteins are manufactured. Manufacturing proteins is a multistep process that’s hard-coded into how our cells operate. Genes, which are made of DNA,