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LOXO-195, a next-generation TRK inhibitor also known as BAY 2731954, has shown signs of clinical activity in individuals with NTRK gene fusion-positive solid tumors that have become resistant to first-generation TRK inhibitors. Results from a phase I clinical trial and a US Food and Drug Administration expanded access program were presented by David Hyman, MD, the Chief of the Early Drug Development Service at Memorial Sloan Kettering Cancer Center (MSK), at the American Association for Cancer Research (AACR) Annual Meeting 2019. This research is featured in the meeting’s press program, and findings are being presented in the “Next Generation of Clinical Trials in Molecularly Driven Therapy” minisymposium.

… Monday, April 1, 2019 LOXO-195, a next-generation TRK inhibitor also known as BAY 2731954, has shown signs of clinical activity in individuals with NTRK gene fusion-positive solid tumors that have become resistant to first-generation TRK inhibitors. Results from a phase I clinical trial and a US Food

Learn about the impact of the MSK COVID-19 Fund and The Society 2019–2020 fundraising efforts.

… Thursday, October 1, 2020 The MSK COVID-19 Fund was established in April in response to the desire of so many in our community to help during the crisis. Thanks to more than 3,000 donors, Board members, and MSK employees, the fund has raised more than $6.2 million — making a crucial difference for MSK

For the past five years, we have prospectively evaluated patients with secondary lymphedema of the upper extremity who presented for surgical consultation at Memorial Sloan Kettering Cancer Center (MSK).

… Wednesday, April 8, 2020 For the past five years, we have prospectively evaluated patients with secondary lymphedema of the upper extremity who presented for surgical consultation at Memorial Sloan Kettering Cancer Center (MSK). In our paper, published recently in the journal Cancers , we shared the

The updated versions can survive longer in the body while still packing a punch against cancer.

… Monday, December 17, 2018 Summary Scientists at Memorial Sloan Kettering are learning how to modify the structure of cancer-fighting CAR T cells to boost their performance. Chimeric antigen receptor (CAR) T cells are genetically engineered human immune cells that are designed to fight cancer. They have

Grab your popcorn and pull up a chair for these video shorts of cell signaling in early mouse development.

… Monday, October 26, 2020 A fundamental part of how embryos develop is the communication that takes place via protein receptors on the surface of cells. Signals relayed through these receptors instruct cells to assume distinct identities and eventually form individual tissues and organs. Innovative microscopy

Find out how parents can help children who have finished cancer treatment feel ready for school again.

… Friday, August 30, 2019 Summary Going back to school after finishing cancer treatment can be exciting yet anxiety-inducing for a child — and a parent. MSK neuropsychologist and child psychologist Stephen Sands has tips to help make the transition smoother. Dr. Stephen Sands Stephen Sands Getting back

Researchers in radiology at Memorial Sloan Kettering continue to assess multiple imaging methods in the quest to improve treatment options and success rates for patients with biliary cancers such as cholangiocarcinoma.

… Wednesday, December 7, 2016 Imaging plays a central role in the management of biliary cancers and, while multidetector computed tomography remains the method of choice for imaging of most hepatobiliary tumors, researchers in radiology at Memorial Sloan Kettering continue to asses other methods in the

Learn about the Green Bronx Machine, a program that allows students to benefit their community by growing and distributing fresh food.

… Friday, June 28, 2019 Summary MSK’s Immigrant Health and Cancer Disparities Service has partnered with a local organization called the Green Bronx Machine to provide fresh fruits and vegetables to underserved people with cancer in New York City. Inside a renovated 100-year-old library within the South

Discover how easy it is to donate blood — and the real impact your donation makes.

… Friday, July 28, 2023 VIDEO | 00:35 Diary of A First-Time Blood Donor Watch MSK employee Meredith Begley go through the process of donating blood. Don't worry — there are no needles in this video! Video Details The more time I spend working at Memorial Sloan Kettering Cancer Center, the more I learn

Researchers have found two gene mutations that many exceptional responders to ipilimumab have in common.

… Wednesday, September 28, 2016 Summary A review of nearly 200 patients receiving the immunotherapy ipilimumab for the treatment of melanoma has found two gene mutations that are linked to exceptional response to the drug. Highlights Exceptional responders experience long-term remission or even are cured