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… Job Title Vice President, Patient Relations

… Job Title Graduate Research Assistant Email [email protected]

… Full Title A Phase II/III Study of Paclitaxel/Carboplatin Alone or Combined with Either Trastuzumab and Hyaluronidase-oysk (HERCEPTIN HYLECTA) or Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf (PHESGO) in HER2 Positive, Stage I-IV Endometrial Serous Carcinoma or Carcinosarcoma (NRG-GY026) (CIRB) Purpose

Structure Maintenance of Chromosome (SMC) complexes are central to chromosome segregation, compaction and DNA repair, thereby impacting on gene expression and regulation. SMC family members control chromosome topology during the cell cycle with ATP-regulated Smc5/6 involved in rescue of stalled replication forks, while ATP- and nuclease-regulated MRE11-Rad50 (MR) is involved in preservation of genomic integrity and suppression of tumorigenesis. Our group has focused on the structural biology of DNA-bound Smc5/6 and MR complexes towards a molecular understanding the mechanisms underlying preservation of genomic integrity and suppression of tumorigenesis. Our group has also focused its efforts on a structure-based mechanistic understanding of homologous recombination regulation during meiosis initiated by Spo11-induced DNA DSBs and the role of accessory factors in modulating the process.

… Structure Maintenance of Chromosome (SMC) complexes are central to chromosome segregation, compaction and DNA repair, thereby impacting on gene expression and regulation. SMC family members that control chromosome topology during the cell cycle, range in eukaryotes from cohesion, condensin and Smc5/6

I am a general surgical pathologist with a special interest in gastrointestinal pathology and neoplastic and non-neoplastic liver pathology. My research focuses on histological and molecular characteristics of familial and sporadic colorectal tumors that would help predict tumor behavior and clinical outcome of patients with such tumors. My interest also includes diagnostic and investigational electron microscopy of carcinomas, mesotheliomas, and other tumors.

… Pathologist Job Title Director, Gastrointestinal Pathology I am a general surgical pathologist with a special interest in gastrointestinal pathology and neoplastic and non-neoplastic liver pathology. My research focuses on histological and molecular characteristics of familial and sporadic colorectal

Soy patóloga quirúrgica general con especial interés en patología gastrointestinal y patología hepática neoplásica y no neoplásica. Mi investigación se centra en las características histológicas y moleculares de los tumores colorrectales familiares y esporádicos que ayudarían a predecir el comportamiento tumoral y el resultado clínico de los pacientes con dichos tumores. Mi interés también incluye la microscopía electrónica de diagnóstico e investigación de carcinomas, mesoteliomas y otros tumores.

… Pathologist Job Title Directora de Patología Gastrointestinal Soy patóloga quirúrgica general con especial interés en patología gastrointestinal y patología hepática neoplásica y no neoplásica. Mi investigación se centra en las características histológicas y moleculares de los tumores colorrectales familiares

… Job Title Research Fellow

… Tea will be served at 1:15 p.m. , immediately preceding the seminar. Audience This seminar is open to the research community. Location Memorial Sloan Kettering Cancer Center Zuckerman Research Center 417 East 68th Street Room ZRC-105 New York, NY 10065 Speaker(s) Michail Lionakis, M.D. Deputy Chief,

… How will I be notified of my acceptance? What additional documentation is required from me after acceptance? Is there a deadline for accepting the elective spot? May I request a change to my elective assignment? Does Memorial Sloan Kettering Cancer Center provide housing for medical students? How will