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Cancer biologist Hans-Guido Wendel pursues both disease-centered and basic discovery research. The disease focus is on lymphocyte malignancies and the basic science arm of the lab explores fundamental mechanisms that control aberrant mRNA translation programs in cancer. Work in these two research areas frequently intersects in surprising ways.

… Our goal is to develop new cancer therapeutics and we are curious to identify biological vulnerabilities in cancer cells that provide opportunities for attack. Our research explores the molecular and cellular changes that drive cancer cells and ways to create new types of therapeutics including small

The laboratory investigates cellular lipid and energy metabolism, in particular the mechanisms and physiology of neutral lipid synthesis and storage in lipid droplets.

… The laboratory investigates cellular lipid and energy metabolism, in particular the mechanisms and physiology of neutral lipid synthesis and storage in lipid droplets. More broadly, the lab studies the mechanisms how cells regulate the abundance of lipids, how they store lipids to buffer fluctuation

Biochemist and Bioengineer Kayvan Keshari explores changes in cancer metabolism to develop advanced imaging techniques and cancer therapeutics.

… The goal of our research program is to improve our biochemical understanding of cancer metabolism and use metabolic changes to develop non-invasive methods for diagnosis as well as approaches to treat cancer. Our work takes advantage of multi-modality methods at all scales, with a special focus in hyperpolarized

The Gladkova lab studies the mechanisms and signals that reshape cellular organelle architecture in response to physiological stimuli.

… The Gladkova lab aims to uncover the principles that govern the shape, distribution and movement of organelles, with the ultimate goal of understanding how organelle architecture supports cellular function. This is essential, because defects in organelle maintenance cause neurodegeneration, and altered

The Akhmanova laboratory studies cell invasion and migration through tissues, and how it is controlled by surrounding tissue cells.

… Welcome to the Akhmanova lab, where we study how cells penetrate and migrate through tissues in vivo . By combining cutting-edge live imaging, mechano-biological techniques, and theoretical modelling, we aim to uncover the secrets behind these intricate processes. Fig.1 Research methodology and goals