Full TitleMolecular Characterization of Neuroblastic Tumors: Correlation with Clinical Outcome
The genetic and biochemical makeup of a tumor influences its aggressiveness and the choice of the most appropriate therapy. The purpose of this research study is to determine the genetic and biochemical makeup of neuroblastic tumors, including neuroblastoma, ganglioneuroblastoma, ganglioneuroma, and paraganglioma. These research studies will include analysis of substances called markers that exist on the surface of cancer cells; cytogenetic studies; the identification of genes related to the development of these cancers and to tumor growth; and studies of tumor growth in test tubes. Patients’ blood and bone marrow will also be tested for the presence of tumor cells or leukemia cells.
To be eligible for this study, patients must have a confirmed diagnosis of a neuroblastic tumor, or a suspected diagnosis of a neuroblastic tumor prior to surgery that may confirm the diagnosis.