Full Title
Observational Study of Commercial Chimeric Antigen Receptor T-cell (CAR T) Therapy in Older Patients with Hematologic Malignancies and with an Embedded Pilot Study of Longitudinal Geriatric and Neurocognitive EvaluationPurpose
CAR T-cell therapy is a form of immunotherapy used to treat some adults with lymphoma. The treatment involves utilizing a patient’s own T cells and genetically modifying them in the laboratory to recognize a protein on their cancer cells. The modified T cells, known as CAR T cells, are then returned to the patient to find and kill cancerous cells throughout the body.
This form of treatment is very intensive. In this study, researchers want to see how older patients respond to CAR T-cell therapy and how the treatment affects their quality of life. Patients will complete a comprehensive geriatric assessment (a review of their physical and socioeconomic health, nutrition, balance, hearing, vision, and mental health) and undergo neurocognitive testing to evaluate their attention, memory, language, reaction time, and perception. They will have these tests before treatment as well as 3 months, 6 months, and 1 year after completing CAR T-cell therapy.