- This drug may have effects on the bone marrow. The bone marrow may not be able to make cells found in the blood as well as it used to for a few weeks.
- This drug is used as part of a treatment plan that includes a stem cell transplant. The stem cell transplant will help to prevent possible deadly health problems. Talk with your child’s doctor.
- It is used before bone marrow or stem cell transplant.
- It is used to treat a type of leukemia.
- It may be given to your child for other reasons. Talk with the doctor.
- If your child has an allergy to this drug or any part of this drug.
- If your child is allergic to any drugs like this one or any other drugs, foods, or other substances. Tell the doctor about the allergy and what signs your child had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
If your child is breast-feeding a baby:
- Talk with the doctor if your child is breast-feeding a baby or plans to breast-feed a baby.
- Tell all of your child’s health care providers that your child is taking this drug. This includes your child’s doctors, nurses, pharmacists, and dentists.
- Have your child’s blood work checked often. Talk with your child’s doctor.
- Talk with the doctor before your child gets any vaccines. Use with this drug may either raise the chance of very bad infection or make the vaccine not work as well.
- Your child may bleed more easily. Make sure your child is careful and avoids injury. Be sure your child has a soft toothbrush.
- Your child may have more chance of getting infections. Avoid crowds and people with infections, colds, or flu.
- Other types of cancer may rarely happen later in life.
- If your child has an upset stomach or loose stools (diarrhea), is throwing up, or is not hungry, talk with the doctor. There may be ways to lower these side effects.
- Chance of seizures may be higher. Talk with the doctor.
- Cataracts may rarely happen.
- A very bad and sometimes deadly heart problem has happened with some people taking this drug. Most of the time, stomach pain and throwing up happened before the heart problem. Talk with the doctor.
- Very bad and sometimes deadly lung problems have happened with this drug. Call the doctor right away if your child has lung or breathing problems like trouble breathing, shortness of breath, or a cough that is new or worse.
- Very bad and sometimes deadly liver problems have happened with this drug. Call your child’s doctor right away if your child has signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- This drug may affect fertility. Fertility problems may lead to not being able to get pregnant or father a child. In both men and women, this may go back to normal but sometimes it may not. Talk with your doctor.
If your child is or may be sexually active:
- If your child is a male and has sex with a female who could get pregnant, they must prevent pregnancy during care and for some time after care ends. Talk with the doctor to see how long they must use birth control after your child stops this drug.
- If your child is a male and his sex partner gets pregnant while he takes this drug or within several months after his last dose, call the doctor right away.
- Have your child use birth control to prevent pregnancy during care and for some time after care ends. Talk with the doctor to see how long your child needs to use birth control after stopping this drug.
If your child is pregnant:
- This drug may cause harm to the unborn baby if your child takes it during pregnancy.
- If your child gets pregnant while taking this drug or within several months after her last dose, call the doctor right away.
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
- Signs of bleeding like throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; or any bleeding that is very bad or that you cannot stop.
- Feeling very tired or weak.
- Very bad belly pain.
- Very upset stomach or throwing up.
- Chest pain.
- Change in eyesight.
If your child has menstrual periods:
- For females, no period.
- Signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
- Signs of electrolyte problems like mood changes, confusion, muscle pain or weakness, a heartbeat that does not feel normal, seizures, not hungry, or very bad upset stomach or throwing up.
- Low mood (depression).
- Very bad dizziness or passing out.
- A fast heartbeat.
- Very bad headache.
- Swelling, warmth, numbness, change of color, or pain in a leg or arm.
- Signs of a weak adrenal gland like a very bad upset stomach or throwing up, very bad dizziness or passing out, muscle weakness, feeling very tired, mood changes, not hungry, or weight loss.
- Dry mouth.
- Change in color of skin.
- Upset stomach or throwing up.
- Loose stools (diarrhea).
- Back pain.
- Hard stools (constipation).
- Runny nose.
- Feeling tired or weak.
- Not able to sleep.
- Mouth irritation or mouth sores.
- Not hungry.
- Belly pain or heartburn.
- Irritation or swelling where the shot was given.
- Give this drug at the same time of day.
- Give this drug with or without food. Give with food if it causes an upset stomach.
- Have your child drink lots of noncaffeine liquids every day unless told to drink less liquid by your child’s doctor.
- It is given as an infusion into a vein over a period of time.
- Other drugs may be given before this drug to help avoid side effects.
- Give a missed dose as soon as you think about it.
- If it is close to the time for your child’s next dose, skip the missed dose and go back to your child’s normal time.
- Do not give 2 doses at the same time or extra doses.
- Call your child’s doctor to find out what to do.
- Store at room temperature.
- Store in a dry place. Do not store in a bathroom.
- If you need to store this drug at home, talk with your child’s doctor, nurse, or pharmacist about how to store it.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Check with your pharmacist about how to throw out unused drugs.
- If your child’s symptoms or health problems do not get better or if they become worse, call your child’s doctor.
- Do not share your child’s drug with others and do not give anyone else’s drug to your child.
- Keep a list of all your child’s drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your child’s doctor.
- Talk with your child’s doctor before giving your child any new drug, including prescription or OTC, natural products, or vitamins.
- Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your child’s doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.